Vasoconstriction

A new activity for platelet-derived growth factor

Bradford C. Berk, R. Wayne Alexander, Tommy A. Brock, Michael A. Gimbrone, R Clinton Webb

Research output: Contribution to journalArticle

320 Citations (Scopus)

Abstract

Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.

Original languageEnglish (US)
Pages (from-to)87-90
Number of pages4
JournalScience
Volume232
Issue number4746
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

Fingerprint

Platelet-Derived Growth Factor
Vasoconstriction
Smooth Muscle Myocytes
Vasoconstrictor Agents
Vascular Smooth Muscle
Mitogens
Angiotensin II
Aorta
Atherosclerosis
Calcium
Peptides

ASJC Scopus subject areas

  • General

Cite this

Berk, B. C., Wayne Alexander, R., Brock, T. A., Gimbrone, M. A., & Webb, R. C. (1986). Vasoconstriction: A new activity for platelet-derived growth factor. Science, 232(4746), 87-90. https://doi.org/10.1126/science.3485309

Vasoconstriction : A new activity for platelet-derived growth factor. / Berk, Bradford C.; Wayne Alexander, R.; Brock, Tommy A.; Gimbrone, Michael A.; Webb, R Clinton.

In: Science, Vol. 232, No. 4746, 01.01.1986, p. 87-90.

Research output: Contribution to journalArticle

Berk, BC, Wayne Alexander, R, Brock, TA, Gimbrone, MA & Webb, RC 1986, 'Vasoconstriction: A new activity for platelet-derived growth factor', Science, vol. 232, no. 4746, pp. 87-90. https://doi.org/10.1126/science.3485309
Berk BC, Wayne Alexander R, Brock TA, Gimbrone MA, Webb RC. Vasoconstriction: A new activity for platelet-derived growth factor. Science. 1986 Jan 1;232(4746):87-90. https://doi.org/10.1126/science.3485309
Berk, Bradford C. ; Wayne Alexander, R. ; Brock, Tommy A. ; Gimbrone, Michael A. ; Webb, R Clinton. / Vasoconstriction : A new activity for platelet-derived growth factor. In: Science. 1986 ; Vol. 232, No. 4746. pp. 87-90.
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