Vasoconstriction: A new activity for platelet-derived growth factor

Bradford C. Berk; R. Wayne Alexander; Tommy A. Brock; Michael A. Gimbrone; R. Clinton Webb

doi:10.1126/science.3485309

Vasoconstriction: A new activity for platelet-derived growth factor

Bradford C. Berk, R. Wayne Alexander, Tommy A. Brock, Michael A. Gimbrone, R. Clinton Webb

Research output: Contribution to journal › Article › peer-review

358 Scopus citations

Abstract

Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.

Original language	English (US)
Pages (from-to)	87-90
Number of pages	4
Journal	Science
Volume	232
Issue number	4746
DOIs	https://doi.org/10.1126/science.3485309
State	Published - 1986
Externally published	Yes

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title = "Vasoconstriction: A new activity for platelet-derived growth factor",

abstract = "Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.",

author = "Berk, {Bradford C.} and {Wayne Alexander}, R. and Brock, {Tommy A.} and Gimbrone, {Michael A.} and {Clinton Webb}, R.",

year = "1986",

doi = "10.1126/science.3485309",

language = "English (US)",

volume = "232",

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journal = "Science",

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T1 - Vasoconstriction

T2 - A new activity for platelet-derived growth factor

AU - Berk, Bradford C.

AU - Wayne Alexander, R.

AU - Brock, Tommy A.

AU - Gimbrone, Michael A.

AU - Clinton Webb, R.

PY - 1986

Y1 - 1986

N2 - Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.

AB - Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.

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Vasoconstriction: A new activity for platelet-derived growth factor

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