Vasoreactivity and restenosis after coronary angioplasty in the atherosclerotic pig model

H. Hata, Y. Ohara, T. Kuga, Tohru Fukai, H. Kasuya, H. Tomoike, A. Takeshita

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11 Scopus citations

Abstract

Background: The effect of coronary angioplasty on coronary spasm remains unknown. We examined the effects of balloon angioplasty, using an oversized balloon, on coronary hypercontraction and eventual restenosis in a pig model of coronary spasm. Methods: We performed balloon angioplasty, using an oversized balloon at the site of coronary spasm superimposed on atherosclerosis with 6 (group A, n = 14) or 1 (group B, n = 14) atmospheres of inflation pressure in miniature pigs. Using coronary angiography we assessed the coronary basal diameter and diameter change in response to histamine and serotonin before, immediately after, and 4 weeks after angioplasty. Histological examinations were performed immediately after and 4 weeks after the angioplasty. Results: Before angioplasty, histamine- and serotonin-induced hypercontraction was reproducibly noted at the atherosclerotic site. Immediately after angioplasty, the coronary diameter became larger (P<0.01) than before angioplasty in group A, but there was no significant difference in group B. The hypercontraction in group A was abolished immediately after and 4 weeks after angioplasty, whereas the hypercontraction in group B was unchanged. Histological examination revealed medial necrosis immediately after and medial fibrosis 4 weeks after angioplasty, which were more prominent in group A. Four weeks after angioplasty, the magnitude of restenosis was greater in group A than in group B. Conclusions: Angioplasty using an oversized balloon with the higher atmosphere of inflation pressure abolished coronary hypercontraction immediately after and 4 weeks after angioplasty, which probably resulted from the irreversible damage to medial smooth muscles; however, this did not prevent restenosis.

Original languageEnglish (US)
Pages (from-to)503-511
Number of pages9
JournalCoronary Artery Disease
Volume6
Issue number6
Publication statusPublished - Jan 1 1995
Externally publishedYes

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Keywords

  • atherosclerosis
  • coronary angioplasty
  • restenosis
  • vasoreactivity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Hata, H., Ohara, Y., Kuga, T., Fukai, T., Kasuya, H., Tomoike, H., & Takeshita, A. (1995). Vasoreactivity and restenosis after coronary angioplasty in the atherosclerotic pig model. Coronary Artery Disease, 6(6), 503-511.