Vertical bone augmentation with simultaneous implant placement using particulate mineralized bone and mesenchymal stem cells: A preliminary study in rabbit

Arash Khojasteh, Mohamadreza Baghaban Eslaminejad, Hamid Nazarian, Golnaz Morad, Seyyedeh Ghazaleh Dashti, Hossein Behnia, Mark R Stevens

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study aimed to assess vertical bone augmentation with simultaneous implant placement in rabbit tibiae using particulate mineralized bone/fibrin glue/mesenchymal stem cell. Bone marrow was aspirated from tibiae of five 10-week-old New Zealand White male rabbits. Right and left tibiae of each rabbit were prepared, and a 3-mm protruding implant from tibial bone was placed in each side. Particulate allogenic bone/fibrin glue/mesenchymal stem cell combination was placed around test implants and particulate bone graft/fibrin glue around controls. Two months postoperatively, the animals were euthanized, and sections were prepared for histological analysis. The mean amount of vertical bone length was higher in the experimental group than the control group (2.09 mm vs 1.03 mm; P < .05). New supracrestal trabecular bone formation was also significantly higher in the test group (28.5 ± 4.5% vs 4.3 ± 1.8%; P < .05). Mesenchymal stem cell/particulate allograft/fibrin glue appears to be a promising combination for vertical bone augmentation around simultaneously inserted implants in rabbit tibia.

Original languageEnglish (US)
Pages (from-to)3-13
Number of pages11
JournalJournal of Oral Implantology
Volume39
Issue number1
DOIs
StatePublished - Feb 1 2013

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Mesenchymal Stromal Cells
Fibrin Tissue Adhesive
Tibia
Rabbits
Bone and Bones
Bone Cements
Osteogenesis
Allografts
Bone Marrow
Transplants
Control Groups

Keywords

  • Bone regeneration
  • Dental implant
  • Mesenchymal stem cell
  • Vertical augmentation

ASJC Scopus subject areas

  • Oral Surgery

Cite this

Vertical bone augmentation with simultaneous implant placement using particulate mineralized bone and mesenchymal stem cells : A preliminary study in rabbit. / Khojasteh, Arash; Eslaminejad, Mohamadreza Baghaban; Nazarian, Hamid; Morad, Golnaz; Dashti, Seyyedeh Ghazaleh; Behnia, Hossein; Stevens, Mark R.

In: Journal of Oral Implantology, Vol. 39, No. 1, 01.02.2013, p. 3-13.

Research output: Contribution to journalArticle

Khojasteh, Arash ; Eslaminejad, Mohamadreza Baghaban ; Nazarian, Hamid ; Morad, Golnaz ; Dashti, Seyyedeh Ghazaleh ; Behnia, Hossein ; Stevens, Mark R. / Vertical bone augmentation with simultaneous implant placement using particulate mineralized bone and mesenchymal stem cells : A preliminary study in rabbit. In: Journal of Oral Implantology. 2013 ; Vol. 39, No. 1. pp. 3-13.
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