Vibrometry: A novel noninvasive application of ultrasonographic physics to estimate wall stress in native aneurysms

Gautam Agarwal, Geza Mozes, Randall R. Kinnick, Peter Gloviczki, Russell E. Bruhnke, Michele Carmo, Tanya L. Hoskin, Kevin E. Bennett, James L. Greenleaf

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Our objective was to test vibrometry as a means to measure changes in aneurysm sac pressure in an in vitro aneurysm model. Explanted porcine abdominal aortas and nitrile rubber tubes were used to model an aneurysm sac. An ultrasound beam was used to vibrate the surface of the aneurysm model. The motion generated on the surface was detected either by reflected laser light or by a second ultrasound probe. This was recorded at different aneurysm pressures. The phase of the propagating wave was measured to assess changes in velocity and to see if there was a correlation with aneurysm pressure. The cumulative phase shift detected by laser or Doppler correlated well with increasing hydrostatic pressure in both the rubber and the porcine aorta model. The square of the mean pressure correlated well with the cumulative phase shift when dynamic pressure was generated by a pump. However, the pulse pressure was poorly correlated with the cumulative phase shift. Noninvasive measurement of changes in aortic aneurysm sac tension is feasible in an in vitro setting using the concept of vibrometry. This could potentially be used to noninvasively detectwall stress in native aneurysms and endotension after endovascular aneurysm repair (EVAR) and to predict the risk of rupture.

Original languageEnglish (US)
Title of host publicationThe Abdominal Aortic Aneurysm
Subtitle of host publicationGenetics, Pathophysiology, and Molecular Biology
PublisherBlackwell Publishing Inc.
Pages197-207
Number of pages11
ISBN (Print)1573316571, 9781573316576
DOIs
Publication statusPublished - Nov 2006
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
Volume1085
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

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Keywords

  • Aneurysm
  • Ultrasound
  • Vibrometry

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

Cite this

Agarwal, G., Mozes, G., Kinnick, R. R., Gloviczki, P., Bruhnke, R. E., Carmo, M., ... Greenleaf, J. L. (2006). Vibrometry: A novel noninvasive application of ultrasonographic physics to estimate wall stress in native aneurysms. In The Abdominal Aortic Aneurysm: Genetics, Pathophysiology, and Molecular Biology (pp. 197-207). (Annals of the New York Academy of Sciences; Vol. 1085). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1383.001