Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

Hanspeter Pircher, Dimitrios Moskofidis, Urs Rohrer, Kurt Bürki, Hans Hengartner, Rolf M. Zinkernagel

Research output: Contribution to journalArticle

444 Citations (Scopus)

Abstract

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalNature
Volume346
Issue number6285
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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Viruses
T-Lymphocytes
Immunologic Monitoring
T-Lymphocyte Epitopes
Neutralizing Antibodies
Human Influenza
Antibody Formation
HIV
Antigens
Mutation
Population

ASJC Scopus subject areas

  • General

Cite this

Pircher, H., Moskofidis, D., Rohrer, U., Bürki, K., Hengartner, H., & Zinkernagel, R. M. (1990). Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature, 346(6285), 629-633. https://doi.org/10.1038/346629a0

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. / Pircher, Hanspeter; Moskofidis, Dimitrios; Rohrer, Urs; Bürki, Kurt; Hengartner, Hans; Zinkernagel, Rolf M.

In: Nature, Vol. 346, No. 6285, 01.01.1990, p. 629-633.

Research output: Contribution to journalArticle

Pircher, H, Moskofidis, D, Rohrer, U, Bürki, K, Hengartner, H & Zinkernagel, RM 1990, 'Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo', Nature, vol. 346, no. 6285, pp. 629-633. https://doi.org/10.1038/346629a0
Pircher H, Moskofidis D, Rohrer U, Bürki K, Hengartner H, Zinkernagel RM. Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature. 1990 Jan 1;346(6285):629-633. https://doi.org/10.1038/346629a0
Pircher, Hanspeter ; Moskofidis, Dimitrios ; Rohrer, Urs ; Bürki, Kurt ; Hengartner, Hans ; Zinkernagel, Rolf M. / Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. In: Nature. 1990 ; Vol. 346, No. 6285. pp. 629-633.
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