Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

Hanspeter Pircher, Dimitrios Moskofidis, Urs Rohrer, Kurt Bürki, Hans Hengartner, Rolf M. Zinkernagel

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Abstract

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope.

Original languageEnglish (US)
Pages (from-to)629-633
Number of pages5
JournalNature
Volume346
Issue number6285
DOIs
StatePublished - Jan 1 1990
Externally publishedYes

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    Pircher, H., Moskofidis, D., Rohrer, U., Bürki, K., Hengartner, H., & Zinkernagel, R. M. (1990). Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature, 346(6285), 629-633. https://doi.org/10.1038/346629a0