Viral perturbations of host networks reflect disease etiology

Natali Gulbahce, Han Yan, Amélie Dricot, Megha Padi, Danielle Byrdsong, Rachel Franchi, Deok Sun Lee, Orit Rozenblatt-Rosen, Jessica C. Mar, Michael A. Calderwood, Amy Baldwin, Bo Zhao, Balaji Santhanam, Pascal Braun, Nicolas Simonis, Kyung Won Huh, Karin Hellner, Miranda Grace, Alyce Chen, Renee RubioJarrod A. Marto, Nicholas A. Christakis, Elliott Kieff, Frederick P. Roth, Jennifer Roecklein-Canfield, James A. DeCaprio, Michael E. Cusick, John Quackenbush, David E. Hill, Karl Münger, Marc Vidal, Albert László Barabási

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Many human diseases, arising from mutations of disease susceptibility genes (genetic diseases), are also associated with viral infections (virally implicated diseases), either in a directly causal manner or by indirect associations. Here we examine whether viral perturbations of host interactome may underlie such virally implicated disease relationships. Using as models two different human viruses, Epstein-Barr virus (EBV) and human papillomavirus (HPV), we find that host targets of viral proteins reside in network proximity to products of disease susceptibility genes. Expression changes in virally implicated disease tissues and comorbidity patterns cluster significantly in the network vicinity of viral targets. The topological proximity found between cellular targets of viral proteins and disease genes was exploited to uncover a novel pathway linking HPV to Fanconi anemia.

Original languageEnglish (US)
Article numbere1002531
JournalPLoS Computational Biology
Volume8
Issue number6
DOIs
StatePublished - Jun 1 2012

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etiology
genetic disorders
Inborn Genetic Diseases
Papillomaviridae
viral proteins
perturbation
Perturbation
disease resistance
Disease Susceptibility
Viral Proteins
Virus Diseases
vertebrate viruses
Human herpesvirus 4
Fanconi Anemia
human diseases
Human Herpesvirus 4
mutation
Comorbidity
Viruses
Susceptibility

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • Ecology
  • Molecular Biology
  • Genetics
  • Cellular and Molecular Neuroscience
  • Computational Theory and Mathematics

Cite this

Gulbahce, N., Yan, H., Dricot, A., Padi, M., Byrdsong, D., Franchi, R., ... Barabási, A. L. (2012). Viral perturbations of host networks reflect disease etiology. PLoS Computational Biology, 8(6), [e1002531]. https://doi.org/10.1371/journal.pcbi.1002531

Viral perturbations of host networks reflect disease etiology. / Gulbahce, Natali; Yan, Han; Dricot, Amélie; Padi, Megha; Byrdsong, Danielle; Franchi, Rachel; Lee, Deok Sun; Rozenblatt-Rosen, Orit; Mar, Jessica C.; Calderwood, Michael A.; Baldwin, Amy; Zhao, Bo; Santhanam, Balaji; Braun, Pascal; Simonis, Nicolas; Huh, Kyung Won; Hellner, Karin; Grace, Miranda; Chen, Alyce; Rubio, Renee; Marto, Jarrod A.; Christakis, Nicholas A.; Kieff, Elliott; Roth, Frederick P.; Roecklein-Canfield, Jennifer; DeCaprio, James A.; Cusick, Michael E.; Quackenbush, John; Hill, David E.; Münger, Karl; Vidal, Marc; Barabási, Albert László.

In: PLoS Computational Biology, Vol. 8, No. 6, e1002531, 01.06.2012.

Research output: Contribution to journalArticle

Gulbahce, N, Yan, H, Dricot, A, Padi, M, Byrdsong, D, Franchi, R, Lee, DS, Rozenblatt-Rosen, O, Mar, JC, Calderwood, MA, Baldwin, A, Zhao, B, Santhanam, B, Braun, P, Simonis, N, Huh, KW, Hellner, K, Grace, M, Chen, A, Rubio, R, Marto, JA, Christakis, NA, Kieff, E, Roth, FP, Roecklein-Canfield, J, DeCaprio, JA, Cusick, ME, Quackenbush, J, Hill, DE, Münger, K, Vidal, M & Barabási, AL 2012, 'Viral perturbations of host networks reflect disease etiology', PLoS Computational Biology, vol. 8, no. 6, e1002531. https://doi.org/10.1371/journal.pcbi.1002531
Gulbahce N, Yan H, Dricot A, Padi M, Byrdsong D, Franchi R et al. Viral perturbations of host networks reflect disease etiology. PLoS Computational Biology. 2012 Jun 1;8(6). e1002531. https://doi.org/10.1371/journal.pcbi.1002531
Gulbahce, Natali ; Yan, Han ; Dricot, Amélie ; Padi, Megha ; Byrdsong, Danielle ; Franchi, Rachel ; Lee, Deok Sun ; Rozenblatt-Rosen, Orit ; Mar, Jessica C. ; Calderwood, Michael A. ; Baldwin, Amy ; Zhao, Bo ; Santhanam, Balaji ; Braun, Pascal ; Simonis, Nicolas ; Huh, Kyung Won ; Hellner, Karin ; Grace, Miranda ; Chen, Alyce ; Rubio, Renee ; Marto, Jarrod A. ; Christakis, Nicholas A. ; Kieff, Elliott ; Roth, Frederick P. ; Roecklein-Canfield, Jennifer ; DeCaprio, James A. ; Cusick, Michael E. ; Quackenbush, John ; Hill, David E. ; Münger, Karl ; Vidal, Marc ; Barabási, Albert László. / Viral perturbations of host networks reflect disease etiology. In: PLoS Computational Biology. 2012 ; Vol. 8, No. 6.
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