Virus spread and immune response following anterior chamber inoculation of HSV-1 Lacking the Beclin-binding domain (BBD)

Ming Zhang, Jason Covar, Nancy Y. Zhang, Wen Chen, Brendan Marshall, Juan Mo, Sally S. Atherton

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The autophagy response induced by HSV-1 infection is antagonized by the Beclin-binding domain (BBD). The purpose of this study was to determine if lack of the BBD affects viral spread and immune response in the eyes and brain. Our results showed that lack of the BBD increases autophagy response and activation of NLRP3 inflammasome, which in turn induces a more rapid innate immune response mediated by macrophage/microglia and NK cells in the injected eye, limiting virus replication and retinal damage. We conclude that autophagy plays a role in controlling HSV-1 infection by more rapid induction of the innate immune response.

Original languageEnglish (US)
Pages (from-to)82-91
Number of pages10
JournalJournal of Neuroimmunology
Volume260
Issue number1-2
DOIs
StatePublished - Apr 22 2013

Keywords

  • Autophagy
  • Beclin-binding domain
  • HSV-1
  • Interferon
  • Retinitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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