Viruses: Microbial spies and saboteurs

Ken S. Rosenthal

Research output: Contribution to journalArticle

Abstract

Every virus shares the same mission, to find a suitable host, subvert the host cells into virus-producing factories, and then spread within and to new hosts. A virus that fails at their mission is eliminated. In pursuit of their mission, viruses can be likened to spies and saboteurs. The mission requires that viruses be able to evade or override the molecular alarms, which are set off by viral structures and activities, the roadblocks and traps within the cell that are set to prevent the production of more viruses, and the innate and immune detection and weapon systems dedicated to restrict the replication and spread of these microbial spies. Viral protein synthesis is both the trigger for establishing and a prominent step in virus replication that is targeted by the major roadblocks set up by the cell to counter the viral mission. Successful viruses have developed specific molecular tools to overcome these and other host defenses. Using the espionage analogy, this review will describe the cellular and systemic protections developed by humans against virus replication and spread and the molecular tools that viruses have developed to override or evade these blocks.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalInfectious Diseases in Clinical Practice
Volume14
Issue number2
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

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Viruses
Virus Replication
Viral Structures
Weapons
Viral Proteins

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Viruses : Microbial spies and saboteurs. / Rosenthal, Ken S.

In: Infectious Diseases in Clinical Practice, Vol. 14, No. 2, 01.03.2006, p. 97-106.

Research output: Contribution to journalArticle

Rosenthal, Ken S. / Viruses : Microbial spies and saboteurs. In: Infectious Diseases in Clinical Practice. 2006 ; Vol. 14, No. 2. pp. 97-106.
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