Visceral hypersensitivity and impaired accommodation in refractory diabetic gastroparesis

A. Kumar, A. Attaluri, S. Hashmi, K. S. Schulze, S. S.C. Rao

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

The pathophysiology of persistent gastrointestinal (GI) symptoms in patients with diabetic gastroparesis is poorly understood. Our aim was to evaluate gastric sensation and accommodation to a meal in patients with diabetic gastroparesis and refractory symptoms. We performed intermittent, phasic balloon distensions of the stomach using a gastric barostat device in 18 patients with diabetes and gastroparesis unresponsive to prokinetic therapy and in 13 healthy volunteers. We assessed the biomechanical, sensory and accommodation responses of the stomach, during fasting and after liquid meal. During balloon distension, the sensory thresholds for discomfort were lower (P < 0.02) in patients with diabetes than those in controls, in both the fasting and the postprandial states. The accommodation response to a meal was significantly impaired (P = 0.01) in patients with diabetes when compared to controls, although fasting gastric tone was similar (P = 0.08). Patients with diabetic gastroparesis and refractory GI symptoms demonstrate sensori-motor dysfunction of the stomach, comprising either impaired accommodation, gastric hypersensitivity or both. An objective evaluation of these biomechanical and sensory properties may provide valuable mechanistic insights that could guide therapy.

Original languageEnglish (US)
Pages (from-to)635-642
Number of pages8
JournalNeurogastroenterology and Motility
Volume20
Issue number6
DOIs
StatePublished - Jun 1 2008
Externally publishedYes

Fingerprint

Gastroparesis
Stomach
Hypersensitivity
Meals
Fasting
Sensory Thresholds
Healthy Volunteers
Equipment and Supplies
Therapeutics

Keywords

  • Accommodation
  • Barostat
  • Diabetes
  • Dyspepsia
  • Gastric motility
  • Gastroparesis
  • Visceral hypersensitivity

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

Cite this

Visceral hypersensitivity and impaired accommodation in refractory diabetic gastroparesis. / Kumar, A.; Attaluri, A.; Hashmi, S.; Schulze, K. S.; Rao, S. S.C.

In: Neurogastroenterology and Motility, Vol. 20, No. 6, 01.06.2008, p. 635-642.

Research output: Contribution to journalArticle

Kumar, A. ; Attaluri, A. ; Hashmi, S. ; Schulze, K. S. ; Rao, S. S.C. / Visceral hypersensitivity and impaired accommodation in refractory diabetic gastroparesis. In: Neurogastroenterology and Motility. 2008 ; Vol. 20, No. 6. pp. 635-642.
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