Vitamin C-mediated Maillard reaction in the lens probed in a transgenic-mouse model

Xingjun Fan, Vincent M. Monnier

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

Aging human lens crystallins are progressively modified by yellow glycation, oxidation, and cross-linked carbonyl compounds that have deleterious properties on protein structure and stability. In order to test the hypothesis that some of these compounds originate from oxidized vitamin C, we have overexpressed the human vitamin C transporter 2 (hSCVT2) in the mouse lens. We find that levels of ascorbic and dehydroascorbic acid are highly elevated compared to the wild type and that the lenses have accumulated yellow color and advanced Maillard reaction products identical with those of the human lens. Treatment of the mice with nucleophilic inhibitors can slow down the process, opening new avenues for the pharmacological prevention of senile cataractogenesis.

Original languageEnglish (US)
Title of host publicationThe Maillard Reaction Recent Advances in Food and Biomedical Sciences
PublisherBlackwell Publishing Inc.
Pages194-200
Number of pages7
ISBN (Print)9781573317, 9789781573316
DOIs
StatePublished - Apr 2008

Publication series

NameAnnals of the New York Academy of Sciences
Volume1126
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632

Keywords

  • Aging
  • Ascorbic acid
  • Cross-linking
  • Crystallin
  • Glycation

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • History and Philosophy of Science

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    Fan, X., & Monnier, V. M. (2008). Vitamin C-mediated Maillard reaction in the lens probed in a transgenic-mouse model. In The Maillard Reaction Recent Advances in Food and Biomedical Sciences (pp. 194-200). (Annals of the New York Academy of Sciences; Vol. 1126). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1433.064