Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice

Alexis Michelle Stranahan, Kim Lee, Bronwen Martin, Stuart Maudsley, Erin Golden, Roy G. Cutler, Mark P. Mattson

Research output: Contribution to journalArticle

196 Citations (Scopus)

Abstract

Diabetes may adversely affect cognitive function, but the underlying mechanisms are unknown. To investigate whether manipulations that enhance neurotrophin levels will also restore neuronal structure and function in diabetes, we examined the effects of wheel running and dietary energy restriction on hippocampal neuron morphology and brain-derived neurotrophic factor (BDNF) levels in db/db mice, a model of insulin resistant diabetes. Running wheel activity, caloric restriction, or the combination of the two treatments increased levels of BDNF in the hippocampus of db/db mice. Enhancement of hippocampal BDNF was accompanied by increases in dendritic spine density on the secondary and tertiary dendrites of dentate granule neurons. These studies suggest that diabetes exerts detrimental effects on hippocampal structure, and that this state can be attenuated by increasing energy expenditure and decreasing energy intake.

Original languageEnglish (US)
Pages (from-to)951-961
Number of pages11
JournalHippocampus
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2009
Externally publishedYes

Fingerprint

Caloric Restriction
Dendritic Spines
Brain-Derived Neurotrophic Factor
Running
Neurons
Nerve Growth Factors
Dendrites
Energy Intake
Cognition
Energy Metabolism
Hippocampus
Insulin
Therapeutics

Keywords

  • Dendrite
  • Diabetes
  • Dietary restriction
  • Exercise
  • Hippocampus

ASJC Scopus subject areas

  • Cognitive Neuroscience

Cite this

Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. / Stranahan, Alexis Michelle; Lee, Kim; Martin, Bronwen; Maudsley, Stuart; Golden, Erin; Cutler, Roy G.; Mattson, Mark P.

In: Hippocampus, Vol. 19, No. 10, 01.10.2009, p. 951-961.

Research output: Contribution to journalArticle

Stranahan, Alexis Michelle ; Lee, Kim ; Martin, Bronwen ; Maudsley, Stuart ; Golden, Erin ; Cutler, Roy G. ; Mattson, Mark P. / Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice. In: Hippocampus. 2009 ; Vol. 19, No. 10. pp. 951-961.
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