Wada memory and timing of stimulus presentation

D. W. Loring, K. J. Meador, G. P. Lee, M. E. Nichols, D. W. King, Anthony M Murro, Yong D Park, J. R. Smith

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We compared Wada memory performance for stimuli presented at two timing intervals following amobarbital injection in 47 non-lesional patients with complex partial seizures (L = 26; R = 21). A significant interaction between seizure focus and timing of presentation was present (P < 0.03). Memory performance for objects whose presentation began approximately 50-55 s following amobarbital administration differed as a function of ipsilateral vs. contralateral injection at a very high level of statistical significance (P < 0.00001). Items presented approximately 4 min, 30 s post injection were also related to seizure onset laterality, but at a lower statistical level (P < 0.01). Presentation of Wada memory stimuli earlier during hemispheric aesthesia yields results that are more sensitive to lateralized temporal lobe seizure onset than does presentation of items later during the procedure.

Original languageEnglish (US)
Pages (from-to)461-464
Number of pages4
JournalEpilepsy Research
Volume26
Issue number3
DOIs
StatePublished - Feb 1 1997

Fingerprint

Seizures
Amobarbital
Injections
Temporal Lobe

Keywords

  • Epilepsy surgery
  • Human epilepsy
  • Memory
  • Temporal lobectomy
  • Wada test

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Loring, D. W., Meador, K. J., Lee, G. P., Nichols, M. E., King, D. W., Murro, A. M., ... Smith, J. R. (1997). Wada memory and timing of stimulus presentation. Epilepsy Research, 26(3), 461-464. https://doi.org/10.1016/S0920-1211(96)01000-5

Wada memory and timing of stimulus presentation. / Loring, D. W.; Meador, K. J.; Lee, G. P.; Nichols, M. E.; King, D. W.; Murro, Anthony M; Park, Yong D; Smith, J. R.

In: Epilepsy Research, Vol. 26, No. 3, 01.02.1997, p. 461-464.

Research output: Contribution to journalArticle

Loring, DW, Meador, KJ, Lee, GP, Nichols, ME, King, DW, Murro, AM, Park, YD & Smith, JR 1997, 'Wada memory and timing of stimulus presentation', Epilepsy Research, vol. 26, no. 3, pp. 461-464. https://doi.org/10.1016/S0920-1211(96)01000-5
Loring DW, Meador KJ, Lee GP, Nichols ME, King DW, Murro AM et al. Wada memory and timing of stimulus presentation. Epilepsy Research. 1997 Feb 1;26(3):461-464. https://doi.org/10.1016/S0920-1211(96)01000-5
Loring, D. W. ; Meador, K. J. ; Lee, G. P. ; Nichols, M. E. ; King, D. W. ; Murro, Anthony M ; Park, Yong D ; Smith, J. R. / Wada memory and timing of stimulus presentation. In: Epilepsy Research. 1997 ; Vol. 26, No. 3. pp. 461-464.
@article{1563946c7ad44c7fac0debafde54190c,
title = "Wada memory and timing of stimulus presentation",
abstract = "We compared Wada memory performance for stimuli presented at two timing intervals following amobarbital injection in 47 non-lesional patients with complex partial seizures (L = 26; R = 21). A significant interaction between seizure focus and timing of presentation was present (P < 0.03). Memory performance for objects whose presentation began approximately 50-55 s following amobarbital administration differed as a function of ipsilateral vs. contralateral injection at a very high level of statistical significance (P < 0.00001). Items presented approximately 4 min, 30 s post injection were also related to seizure onset laterality, but at a lower statistical level (P < 0.01). Presentation of Wada memory stimuli earlier during hemispheric aesthesia yields results that are more sensitive to lateralized temporal lobe seizure onset than does presentation of items later during the procedure.",
keywords = "Epilepsy surgery, Human epilepsy, Memory, Temporal lobectomy, Wada test",
author = "Loring, {D. W.} and Meador, {K. J.} and Lee, {G. P.} and Nichols, {M. E.} and King, {D. W.} and Murro, {Anthony M} and Park, {Yong D} and Smith, {J. R.}",
year = "1997",
month = "2",
day = "1",
doi = "10.1016/S0920-1211(96)01000-5",
language = "English (US)",
volume = "26",
pages = "461--464",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Wada memory and timing of stimulus presentation

AU - Loring, D. W.

AU - Meador, K. J.

AU - Lee, G. P.

AU - Nichols, M. E.

AU - King, D. W.

AU - Murro, Anthony M

AU - Park, Yong D

AU - Smith, J. R.

PY - 1997/2/1

Y1 - 1997/2/1

N2 - We compared Wada memory performance for stimuli presented at two timing intervals following amobarbital injection in 47 non-lesional patients with complex partial seizures (L = 26; R = 21). A significant interaction between seizure focus and timing of presentation was present (P < 0.03). Memory performance for objects whose presentation began approximately 50-55 s following amobarbital administration differed as a function of ipsilateral vs. contralateral injection at a very high level of statistical significance (P < 0.00001). Items presented approximately 4 min, 30 s post injection were also related to seizure onset laterality, but at a lower statistical level (P < 0.01). Presentation of Wada memory stimuli earlier during hemispheric aesthesia yields results that are more sensitive to lateralized temporal lobe seizure onset than does presentation of items later during the procedure.

AB - We compared Wada memory performance for stimuli presented at two timing intervals following amobarbital injection in 47 non-lesional patients with complex partial seizures (L = 26; R = 21). A significant interaction between seizure focus and timing of presentation was present (P < 0.03). Memory performance for objects whose presentation began approximately 50-55 s following amobarbital administration differed as a function of ipsilateral vs. contralateral injection at a very high level of statistical significance (P < 0.00001). Items presented approximately 4 min, 30 s post injection were also related to seizure onset laterality, but at a lower statistical level (P < 0.01). Presentation of Wada memory stimuli earlier during hemispheric aesthesia yields results that are more sensitive to lateralized temporal lobe seizure onset than does presentation of items later during the procedure.

KW - Epilepsy surgery

KW - Human epilepsy

KW - Memory

KW - Temporal lobectomy

KW - Wada test

UR - http://www.scopus.com/inward/record.url?scp=0030909843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030909843&partnerID=8YFLogxK

U2 - 10.1016/S0920-1211(96)01000-5

DO - 10.1016/S0920-1211(96)01000-5

M3 - Article

VL - 26

SP - 461

EP - 464

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 3

ER -