Wada memory testing and hippocampal volume measurements in the evaluation for temporal lobectomy

D. W. Loring, A. M. Murro, K. J. Meador, G. P. Lee, C. A. Gratton, M. E. Nichols, B. B. Gallagher, D. W. King, J. R. Smith

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

We examined the relationship of Wada memory performance and MRI hippocampal volume measurements to laterality of ultimate seizure localization in 20 patients with complex partial seizures who later underwent temporal lobectomy: Discriminant function analysis employing both Wada memory test asymmetries and hippocampal volume asymmetries correctly classified 100% of the patients into left and right temporal lobe groups. Wada memory asymmetries alone correctly classified 90% of the sample (80% of the sample when the discriminant function included all patients except the one being classified), and hippocampal volume asymmetries alone correctly classified 90% of the patients. A significant correlation was present between Wada memory asymmetries and hippocampal volume asymmetries (r = 0.78), indicating that structural evidence of reduced hippocampal, volume has a functional correlate reflected by Wada memory performance. These data suggest that the combination of functional and structural measures is of value in the preoperative evaluation for epilepsy surgery.

Original languageEnglish (US)
Pages (from-to)1789-1793
Number of pages5
JournalNeurology
Volume43
Issue number9
DOIs
StatePublished - Jan 1 1993

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'Wada memory testing and hippocampal volume measurements in the evaluation for temporal lobectomy'. Together they form a unique fingerprint.

  • Cite this

    Loring, D. W., Murro, A. M., Meador, K. J., Lee, G. P., Gratton, C. A., Nichols, M. E., Gallagher, B. B., King, D. W., & Smith, J. R. (1993). Wada memory testing and hippocampal volume measurements in the evaluation for temporal lobectomy. Neurology, 43(9), 1789-1793. https://doi.org/10.1212/wnl.43.9.1789