TY - JOUR
T1 - Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women
AU - Hinton, P. S.
AU - Rector, R. S.
AU - Linden, M. A.
AU - Warner, S. O.
AU - Dellsperger, Kevin C
AU - Chockalingam, A.
AU - Whaley-Connell, A. T.
AU - Liu, Y.
AU - Thomas, T. R.
N1 - Funding Information:
This study was supported by the F21C Summer Research Program, the Department of Nutritional Sciences and Exercise Physiology, and NIH ROI DK67036 (TRT).
PY - 2012/5
Y1 - 2012/5
N2 - BACKGROUND/OBJECTIVES:Moderate, long-term weight loss results in the loss of bone mass in overweight or obese premenopausal women. However, whether these changes persist during weight maintenance or regain remains to be determined.SUBJECTS/METHODS:Overweight or obese (body mass index: 25.8-42.5 kg/m 2) women (n=40) with at least two risk factors for the metabolic syndrome participated in this 12-month study that examined the effects of prescribed weight loss and regain, with or without exercise, on bone turnover and on bone mineral density (BMD) in a subset of participants (n=24). During the first 6 month, participants lost ∼10% of their initial body weight via energy restriction and supervised aerobic exercise. Following weight loss, participants were randomly assigned to either an exercise or a no exercise treatment for the regain (+50% of weight lost) phase. A one-way (time) repeated measures one-factor analysis of variance (RMANOVA) tested the effects of weight loss on BMD and bone turnover, and a two-way RMANOVA (time, exercise) was used to examine the effects of exercise during weight regain.RESULTS:Hip (P=0.007) and lumbar spine (P=0.05) BMD decreased with weight loss, and remained reduced after weight regain with or without exercise. Likewise, the weight-loss- associated increases in osteocalcin (P<0.001) and C-terminal peptide of type I collagen (P<0.001) persisted following weight regain, independent of exercise.CONCLUSIONS:The results of the present study, which is the first to examine changes in bone mass and turnover during carefully controlled weight regain, suggest that weight-loss-induced perturbations in bone mass and turnover persist after partial weight regain, regardless of whether regular weight-bearing aerobic exercise was continued.
AB - BACKGROUND/OBJECTIVES:Moderate, long-term weight loss results in the loss of bone mass in overweight or obese premenopausal women. However, whether these changes persist during weight maintenance or regain remains to be determined.SUBJECTS/METHODS:Overweight or obese (body mass index: 25.8-42.5 kg/m 2) women (n=40) with at least two risk factors for the metabolic syndrome participated in this 12-month study that examined the effects of prescribed weight loss and regain, with or without exercise, on bone turnover and on bone mineral density (BMD) in a subset of participants (n=24). During the first 6 month, participants lost ∼10% of their initial body weight via energy restriction and supervised aerobic exercise. Following weight loss, participants were randomly assigned to either an exercise or a no exercise treatment for the regain (+50% of weight lost) phase. A one-way (time) repeated measures one-factor analysis of variance (RMANOVA) tested the effects of weight loss on BMD and bone turnover, and a two-way RMANOVA (time, exercise) was used to examine the effects of exercise during weight regain.RESULTS:Hip (P=0.007) and lumbar spine (P=0.05) BMD decreased with weight loss, and remained reduced after weight regain with or without exercise. Likewise, the weight-loss- associated increases in osteocalcin (P<0.001) and C-terminal peptide of type I collagen (P<0.001) persisted following weight regain, independent of exercise.CONCLUSIONS:The results of the present study, which is the first to examine changes in bone mass and turnover during carefully controlled weight regain, suggest that weight-loss-induced perturbations in bone mass and turnover persist after partial weight regain, regardless of whether regular weight-bearing aerobic exercise was continued.
KW - bone mineral density
KW - bone turnover
KW - weight loss
KW - weight regain
UR - http://www.scopus.com/inward/record.url?scp=84860649565&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860649565&partnerID=8YFLogxK
U2 - 10.1038/ejcn.2011.212
DO - 10.1038/ejcn.2011.212
M3 - Article
C2 - 22190134
AN - SCOPUS:84860649565
SN - 0954-3007
VL - 66
SP - 606
EP - 612
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 5
ER -