Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women

P. S. Hinton, R. S. Rector, M. A. Linden, S. O. Warner, Kevin C Dellsperger, A. Chockalingam, A. T. Whaley-Connell, Y. Liu, T. R. Thomas

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

BACKGROUND/OBJECTIVES:Moderate, long-term weight loss results in the loss of bone mass in overweight or obese premenopausal women. However, whether these changes persist during weight maintenance or regain remains to be determined.SUBJECTS/METHODS:Overweight or obese (body mass index: 25.8-42.5 kg/m 2) women (n=40) with at least two risk factors for the metabolic syndrome participated in this 12-month study that examined the effects of prescribed weight loss and regain, with or without exercise, on bone turnover and on bone mineral density (BMD) in a subset of participants (n=24). During the first 6 month, participants lost ∼10% of their initial body weight via energy restriction and supervised aerobic exercise. Following weight loss, participants were randomly assigned to either an exercise or a no exercise treatment for the regain (+50% of weight lost) phase. A one-way (time) repeated measures one-factor analysis of variance (RMANOVA) tested the effects of weight loss on BMD and bone turnover, and a two-way RMANOVA (time, exercise) was used to examine the effects of exercise during weight regain.RESULTS:Hip (P=0.007) and lumbar spine (P=0.05) BMD decreased with weight loss, and remained reduced after weight regain with or without exercise. Likewise, the weight-loss- associated increases in osteocalcin (P<0.001) and C-terminal peptide of type I collagen (P<0.001) persisted following weight regain, independent of exercise.CONCLUSIONS:The results of the present study, which is the first to examine changes in bone mass and turnover during carefully controlled weight regain, suggest that weight-loss-induced perturbations in bone mass and turnover persist after partial weight regain, regardless of whether regular weight-bearing aerobic exercise was continued.

Original languageEnglish (US)
Pages (from-to)606-612
Number of pages7
JournalEuropean Journal of Clinical Nutrition
Volume66
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Bone Remodeling
Bone Density
Weight Loss
Exercise
Weights and Measures
Bone and Bones
Statistical Factor Analysis
Analysis of Variance
Osteocalcin
Weight-Bearing
Collagen Type I
Hip
Spine
Body Mass Index
Body Weight
Maintenance
Peptides

Keywords

  • bone mineral density
  • bone turnover
  • weight loss
  • weight regain

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women. / Hinton, P. S.; Rector, R. S.; Linden, M. A.; Warner, S. O.; Dellsperger, Kevin C; Chockalingam, A.; Whaley-Connell, A. T.; Liu, Y.; Thomas, T. R.

In: European Journal of Clinical Nutrition, Vol. 66, No. 5, 01.05.2012, p. 606-612.

Research output: Contribution to journalArticle

Hinton, PS, Rector, RS, Linden, MA, Warner, SO, Dellsperger, KC, Chockalingam, A, Whaley-Connell, AT, Liu, Y & Thomas, TR 2012, 'Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women', European Journal of Clinical Nutrition, vol. 66, no. 5, pp. 606-612. https://doi.org/10.1038/ejcn.2011.212
Hinton, P. S. ; Rector, R. S. ; Linden, M. A. ; Warner, S. O. ; Dellsperger, Kevin C ; Chockalingam, A. ; Whaley-Connell, A. T. ; Liu, Y. ; Thomas, T. R. / Weight-loss-associated changes in bone mineral density and bone turnover after partial weight regain with or without aerobic exercise in obese women. In: European Journal of Clinical Nutrition. 2012 ; Vol. 66, No. 5. pp. 606-612.
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AU - Rector, R. S.

AU - Linden, M. A.

AU - Warner, S. O.

AU - Dellsperger, Kevin C

AU - Chockalingam, A.

AU - Whaley-Connell, A. T.

AU - Liu, Y.

AU - Thomas, T. R.

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N2 - BACKGROUND/OBJECTIVES:Moderate, long-term weight loss results in the loss of bone mass in overweight or obese premenopausal women. However, whether these changes persist during weight maintenance or regain remains to be determined.SUBJECTS/METHODS:Overweight or obese (body mass index: 25.8-42.5 kg/m 2) women (n=40) with at least two risk factors for the metabolic syndrome participated in this 12-month study that examined the effects of prescribed weight loss and regain, with or without exercise, on bone turnover and on bone mineral density (BMD) in a subset of participants (n=24). During the first 6 month, participants lost ∼10% of their initial body weight via energy restriction and supervised aerobic exercise. Following weight loss, participants were randomly assigned to either an exercise or a no exercise treatment for the regain (+50% of weight lost) phase. A one-way (time) repeated measures one-factor analysis of variance (RMANOVA) tested the effects of weight loss on BMD and bone turnover, and a two-way RMANOVA (time, exercise) was used to examine the effects of exercise during weight regain.RESULTS:Hip (P=0.007) and lumbar spine (P=0.05) BMD decreased with weight loss, and remained reduced after weight regain with or without exercise. Likewise, the weight-loss- associated increases in osteocalcin (P<0.001) and C-terminal peptide of type I collagen (P<0.001) persisted following weight regain, independent of exercise.CONCLUSIONS:The results of the present study, which is the first to examine changes in bone mass and turnover during carefully controlled weight regain, suggest that weight-loss-induced perturbations in bone mass and turnover persist after partial weight regain, regardless of whether regular weight-bearing aerobic exercise was continued.

AB - BACKGROUND/OBJECTIVES:Moderate, long-term weight loss results in the loss of bone mass in overweight or obese premenopausal women. However, whether these changes persist during weight maintenance or regain remains to be determined.SUBJECTS/METHODS:Overweight or obese (body mass index: 25.8-42.5 kg/m 2) women (n=40) with at least two risk factors for the metabolic syndrome participated in this 12-month study that examined the effects of prescribed weight loss and regain, with or without exercise, on bone turnover and on bone mineral density (BMD) in a subset of participants (n=24). During the first 6 month, participants lost ∼10% of their initial body weight via energy restriction and supervised aerobic exercise. Following weight loss, participants were randomly assigned to either an exercise or a no exercise treatment for the regain (+50% of weight lost) phase. A one-way (time) repeated measures one-factor analysis of variance (RMANOVA) tested the effects of weight loss on BMD and bone turnover, and a two-way RMANOVA (time, exercise) was used to examine the effects of exercise during weight regain.RESULTS:Hip (P=0.007) and lumbar spine (P=0.05) BMD decreased with weight loss, and remained reduced after weight regain with or without exercise. Likewise, the weight-loss- associated increases in osteocalcin (P<0.001) and C-terminal peptide of type I collagen (P<0.001) persisted following weight regain, independent of exercise.CONCLUSIONS:The results of the present study, which is the first to examine changes in bone mass and turnover during carefully controlled weight regain, suggest that weight-loss-induced perturbations in bone mass and turnover persist after partial weight regain, regardless of whether regular weight-bearing aerobic exercise was continued.

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