Whole-body vibration mimics the metabolic effects of exercise in male leptin receptor-deficient mice

Meghan Elizabeth McGee Lawrence, Karl H. Wenger, Sudipta Misra, Catherine Lucy Davis, Norman K. Pollock, Mohammed Elsayed Elsalanty, Kehong Ding, Carlos M Isales, Mark W Hamrick, Marlena Wosiski-Kuhn, Phonepasong Arounleut, Mark P. Mattson, Roy G. Cutler, Jack C Yu, Alexis Michelle Stranahan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Whole-body vibration (WBV) has gained attention as a potential exercise mimetic, but direct comparisons with the metabolic effects of exercise are scarce. To determine whether WBV recapitulates the metabolic and osteogenic effects of physical activity, we exposed male wild-type (WT) and leptin receptor-deficient (db/db) mice to daily treadmill exercise (TE) or WBVfor 3 months. Body weights were analyzed and compared with WT and db/db mice that remained sedentary. Glucose and insulin tolerance testing revealed comparable attenuation of hyperglycemia and insulin resistance in db/db mice following TE or WBV. Both interventions reduced body weight in db/ db mice and normalized muscle fiber diameter. TE orWBValso attenuated adipocyte hypertrophy in visceral adipose tissue and reduced hepatic lipid content in db/db mice. Although the effects of leptin receptor deficiency on cortical bone structure were not eliminated by either intervention, exercise and WBV increased circulating levels of osteocalcin in db/db mice. In the context of increased serum osteocalcin, the modest effects of TE and WBV on bone geometry, mineralization, and biomechanics may reflect subtle increases in osteoblast activity in multiple areas of the skeleton. Taken together, these observations indicate that WBV recapitulates the effects of exercise on metabolism in type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)1160-1171
Number of pages12
JournalEndocrinology
Volume158
Issue number5
DOIs
StatePublished - May 1 2017

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Vibration
Leptin Receptors
Osteocalcin
Body Weight
Physiologic Calcification
Intra-Abdominal Fat
Osteoblasts
Biomechanical Phenomena
Adipocytes
Skeleton
Hyperglycemia
Type 2 Diabetes Mellitus
Hypertrophy
Insulin Resistance
mouse leptin receptor
Insulin
Lipids
Glucose
Muscles
Liver

ASJC Scopus subject areas

  • Endocrinology

Cite this

Whole-body vibration mimics the metabolic effects of exercise in male leptin receptor-deficient mice. / McGee Lawrence, Meghan Elizabeth; Wenger, Karl H.; Misra, Sudipta; Davis, Catherine Lucy; Pollock, Norman K.; Elsalanty, Mohammed Elsayed; Ding, Kehong; Isales, Carlos M; Hamrick, Mark W; Wosiski-Kuhn, Marlena; Arounleut, Phonepasong; Mattson, Mark P.; Cutler, Roy G.; Yu, Jack C; Stranahan, Alexis Michelle.

In: Endocrinology, Vol. 158, No. 5, 01.05.2017, p. 1160-1171.

Research output: Contribution to journalArticle

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