Why sinonasal disease spares the inferior turbinate: An immunohistochemical analysis

Lauren C. White, Paul Maurice Weinberger, Hannah Coulson, Dehuang Guo, David Jang, Jose Gurrola, Stilianos E Kountakis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives/Hypothesis Clinically, inflammatory polyps are found in the middle turbinate (MT) in patients with chronic rhinosinusitis (CRS) but not in the inferior turbinate (IT). The purpose of this study was to investigate differences in protein expression between IT and MT tissue in patients with CRS. Study Design Prospective cohort. Methods Pathologic specimens obtained from patients with CRS undergoing functional endoscopic sinus surgery with IT reduction were evaluated by immunohistochemical analysis of inflammatory markers cysteinyl leukotriene 1 receptor (CysLT1R), toll-like receptor 2 (TLR2), and vascular cell adhesion molecule 1 (VCAM1). Protein expression was quantified with nuance multispectral analysis and results compared between MT and IT tissue. Results The total expression of VCAM1 and CysLT1R was decreased in the IT compared to the MT. There was no difference in total TLR2 expression between the IT and MT. When comparing patients with eosinophilic CRS to noneosinophilic CRS (neCRS), there was decreased expression of VCAM1 in the IT of patients with neCRS. When comparing patients with nasal polyposis to those without polyps, there was decreased expression of VCAM1 in the IT of patients without polyps. Conclusions There is a difference in protein receptor expression of VCAM1 and CysLT1R in MT compared to IT tissue. Although the leukotrienes are a well-known target for treatment of chronic sinusitis, this is the first study demonstrating an upregulation of VCAM1 expression in the MT and could be a potential future target for the treatment of CRS.

Original languageEnglish (US)
Pages (from-to)E179-E183
JournalLaryngoscope
Volume126
Issue number5
DOIs
StatePublished - May 1 2016

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Turbinates
Vascular Cell Adhesion Molecule-1
Polyps
Toll-Like Receptor 2
Proteins
Leukotrienes
Sinusitis

Keywords

  • Chronic sinusitis
  • inferior turbinate
  • inflammatory protein expression
  • middle turbinate

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

White, L. C., Weinberger, P. M., Coulson, H., Guo, D., Jang, D., Gurrola, J., & Kountakis, S. E. (2016). Why sinonasal disease spares the inferior turbinate: An immunohistochemical analysis. Laryngoscope, 126(5), E179-E183. https://doi.org/10.1002/lary.25791

Why sinonasal disease spares the inferior turbinate : An immunohistochemical analysis. / White, Lauren C.; Weinberger, Paul Maurice; Coulson, Hannah; Guo, Dehuang; Jang, David; Gurrola, Jose; Kountakis, Stilianos E.

In: Laryngoscope, Vol. 126, No. 5, 01.05.2016, p. E179-E183.

Research output: Contribution to journalArticle

White, LC, Weinberger, PM, Coulson, H, Guo, D, Jang, D, Gurrola, J & Kountakis, SE 2016, 'Why sinonasal disease spares the inferior turbinate: An immunohistochemical analysis', Laryngoscope, vol. 126, no. 5, pp. E179-E183. https://doi.org/10.1002/lary.25791
White LC, Weinberger PM, Coulson H, Guo D, Jang D, Gurrola J et al. Why sinonasal disease spares the inferior turbinate: An immunohistochemical analysis. Laryngoscope. 2016 May 1;126(5):E179-E183. https://doi.org/10.1002/lary.25791
White, Lauren C. ; Weinberger, Paul Maurice ; Coulson, Hannah ; Guo, Dehuang ; Jang, David ; Gurrola, Jose ; Kountakis, Stilianos E. / Why sinonasal disease spares the inferior turbinate : An immunohistochemical analysis. In: Laryngoscope. 2016 ; Vol. 126, No. 5. pp. E179-E183.
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