Projects 1975 2019

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Nephritis
Podocytes
Peptides
Glomerulonephritis
Endothelial Cells
Fecal Incontinence
Therapeutics
Lower Gastrointestinal Tract
Pelvic Floor
Muscle Strength
Myeloid Cells
Carcinogenesis
Neoplasms
Inflammation
Kupffer Cells
Glypicans
alpha-Fetoproteins
Hepatocellular Carcinoma
Vaccines
Autoantigens
Campylobacter jejuni
Campylobacter
Biofilms
Virulence
Regulon

The Role of Endothelin-1 in Sickle Cell Disease

Meiler, S., Pollock, D. & Kutlar, A.

National Institutes of Health

8/15/135/31/18

Project: Research project

Sickle Cell Anemia
Endothelin-1
Translational Medical Research
Research
Pain
Catenins
Dendritic Cells
Autoimmune Experimental Encephalomyelitis
Brain
Multiple Sclerosis

Engineering DNA nanoparticles to create immune tolerance

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

6/15/135/31/17

Project: Research project

Immune Tolerance
Indoleamine-Pyrrole 2,3,-Dioxygenase
Nanoparticles
DNA
Interferons
Spinal Cord Diseases
Veterans
Spinal Cord Injuries
Bone Density
Photon Absorptiometry
Catenins
beta Catenin
Dendritic Cells
Inflammation
Inflammatory Bowel Diseases
T-Lymphocytes
Recurrence
Drug Therapy
Neoplasms
Immunity
Blood Vessels
Type 2 Diabetes Mellitus
Indoleamine-Pyrrole 2,3,-Dioxygenase
Arginase
Cytokines
Molecular Chaperones
Neurodegenerative Diseases
Molecular Probes
Humulus
Metabolic Diseases
Angiotensin II
High Fat Diet
Adipose Tissue
Atherosclerosis
Blood Vessels
Subunit Vaccines
Interferon-gamma
T-Lymphocytes
Neoplasms
Immunotherapy
Acute Lung Injury
Endothelial Cells
Protein Kinase C-alpha
Adenosine
Proteins
Bone and Bones
Food
Mesenchymal Stromal Cells
Stem Cells
Leptin
Campylobacter jejuni
Virulence
Regulon
Gastroenteritis
Biofilms
Nephritis
Antibodies
Pharmaceutical Preparations
Kidney
Glomerulonephritis
Subunit Vaccines
Melanoma
Vaccines
T-Lymphocytes
Neoplasms

NCMHD Southeastern Exploratory Sickle Cell Center of Excellence

Adamkiewicz, T., Gibson, R. W., Ikuta, T., Kutlar, A., Gibson, R. W., Gibson, R. W. & Tuan Lo, D.

National Institutes of Health

5/28/0912/31/15

Project: Research project

Sickle Cell Anemia
Hydroxyurea
gamma-Globins
Globins
Opioid Analgesics

T cell regulation by IDO-competent plasmacytoid dendritic cells

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

5/22/094/30/12

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Dendritic Cells
T-Lymphocytes
Islets of Langerhans
Inflammation

Manipulating natural host immunoregulation via IDO during viral Infection

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

5/1/094/30/15

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Virus Diseases
T-Lymphocytes
Regulatory T-Lymphocytes
Infection

Mechanisms of Vascular Dysfunction in Cirrhosis

Khurana, S.

National Institutes of Health

7/28/086/30/14

Project: Research project

Bile Acids and Salts
Gastroenterology
Blood Vessels
Vasodilation
Fibrosis
Stem Cells
CXCR4 Receptors
Myocardial Ischemia
Myocardium
Cell Survival
Immunity
Immunization
T-Lymphocytes
Antigen Presentation
Immunotherapy
Adenosine Triphosphate
Lung
Endothelial Cells
Electric Impedance
GTP-Binding Proteins
Transforming Growth Factor beta
Permeability
Endothelial Cells
p38 Mitogen-Activated Protein Kinases
Electric Impedance

IDO dependent T cell suppression

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

12/1/0411/30/10

Project: Research project

T-Lymphocytes
Allografts
Immunity
Cell Proliferation
Indoleamine-Pyrrole 2,3,-Dioxygenase
Campylobacter jejuni
DNA Methylation
Genes
Orphaned Children
Gastroenteritis
Subunit Vaccines
Neoplasms
Cytotoxic T-Lymphocytes
Helper-Inducer T-Lymphocytes
T-Lymphocyte Epitopes
Campylobacter jejuni
Membrane Proteins
Vaccines
Campylobacter Infections
Immunity
Abdominal Aortic Aneurysm
Angiotensin II
Aneurysm
Oxidative Stress
Peroxidase
Campylobacter jejuni
Proteins
Temperature
Poultry
Gastroenteritis
HLA-G Antigens
Dendritic Cells
Transplantation
Allografts
T-Lymphocytes
Endotoxins
Blood Vessels
Atherosclerosis
Inflammation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Gastric Inhibitory Polypeptide
Bone Remodeling
Bone and Bones
Bone Resorption
Peptide Receptors
Gene Deletion
Proteins
Transgenes
Research Personnel
Genetic Recombination
Dendritic Cells
Immunity
Allergy and Immunology
Neoplasms
Cell Biology

Regulation of T cell immunity by indol 2,3 dioxygenase

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

4/1/023/31/08

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Dioxygenases
Immunity
T-Lymphocytes
Complement Activation
Factor V
Sickle Cell Anemia
Genetic Polymorphisms
Mutation
Stroke

SPORE in Prostate Cancer

Young, C., Fatemi, M., Morris, J. C., Thibodeau, S. N., Vile, R., Vasmatzis, G., Jenkins, R. B., Bergstralh, E. J., Cheville, J., Klee, G., Tindall, D. J., Davis, B., Sargent, D., Layton, D., Vuk-Pavlovic, S. & Celis, E.

National Institutes of Health

8/31/018/31/13

Project: Research project

Prostatic Neoplasms
Cytotoxic T-Lymphocytes
Helper-Inducer T-Lymphocytes
Neoplasms
Therapeutics
Calmodulin
Thrombin
Endothelial Cells
Permeability
Myosin-Light-Chain Kinase

IN VIVO STUDIES OF VCAM-1 IN IMMUNITY

Koni, P.

National Institutes of Health

7/1/015/31/07

Project: Research project

Vascular Cell Adhesion Molecule-1
Immunity
T-Lymphocytes
Dendritic Cells
Peripheral Tolerance
Microtubules
Endothelial Cells
Lung
Thrombin
Phosphorylation

VASCULAR MECHANISMS IN ATHEROGENESIS

Lentz, S., Faraci, F., Farci, F., Sigmund, C. D., Heistad, D. & Weintraub, N. L.

National Institutes of Health

6/1/004/30/16

Project: Research project

Surface-Active Agents
Smooth Muscle Myocytes
Pulmonary Surfactant-Associated Protein D
Blood Vessels
Inflammation
Defecation
Constipation
Brain
Therapeutics
Laxatives
Prostatic Neoplasms
Cytotoxic T-Lymphocytes
Major Histocompatibility Complex
T-Lymphocyte Epitopes
Antigens
Epitopes
T-Lymphocyte Epitopes
Cancer Vaccines
Cytotoxic T-Lymphocytes
Cell- and Tissue-Based Therapy

T CELL IMMUNOREGULATION BY TRYPTOPHAN DEPLETION

Mellor, A. L. & Mellor, A. L.

National Institutes of Health

12/1/983/31/04

Project: Research project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Tryptophan
T-Lymphocytes
Embryo Loss
Isoantigens