Afshin Ameri

Professor

  • 522 Citations
  • 11 h-Index
19922015
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Factor IX Medicine & Life Sciences
Hemophilia A Medicine & Life Sciences
Factor VIII Medicine & Life Sciences
von Willebrand Factor Medicine & Life Sciences
Hemorrhage Medicine & Life Sciences
Adult Respiratory Distress Syndrome Medicine & Life Sciences
Blood Coagulation Medicine & Life Sciences
Genes Medicine & Life Sciences

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Research Output 1992 2015

16 Citations

Changes in the amino acid sequence of the recombinant human factor VIIa analog, vatreptacog alfa, are associated with clinical immunogenicity

Mahlangu, J. N., Weldingh, K. N., Lentz, S. R., Kaicker, S., Karim, F. A., Matsushita, T., Recht, M., Tomczak, W., Windyga, J., Ehrenforth, S., Knobe, K., Weltermann, A., de Paula, E., Cerqueira, M., Zupancic-Salek, S., Katsarou, O., Economou, M., Nemes, L., Boda, Z., Santagostino, E. & 22 othersTagariello, G., Hanabusa, H., Fukutake, K., Shima, M., Serban, M., Elezo-vic, I., Savic, A., Shen, M., Chuansumrit, A., Angchaisuksiri, P., Kavakli, K., Sasmaz, I., Madan, B., Giangrande, P., Kempton, C., Young, G., Quon, D., Ameri, A., Kuriakose, P., Obzut, D., Wang, M. & Ortiz, I., Jan 1 2015, In : Journal of Thrombosis and Haemostasis. 13, 11, p. 1989-1998 10 p.

Research output: Contribution to journalArticle

Amino Acid Sequence
Anti-Idiotypic Antibodies
Hemophilia A
Pharmaceutical Preparations
Epitope Mapping
38 Citations

Recombinant factor VIIa analog in the management of hemophilia with inhibitors: Results from a multicenter, randomized, controlled trial of vatreptacog alfa

Lentz, S. R., Ehrenforth, S., Abdul Karim, F., Matsushita, T., Weldingh, K. N., Windyga, J., Mahlangu, J. N., Weltermann, A., de Paula, E., Cerqueira, M., Zupancic-Salek, S., Katsarou, O., Economou, M., Nemes, L., Boda, Z., Santagostino, E., Tagariello, G., Hanabusa, H., Fukutake, K., Taki, M. & 33 othersShima, M., Gorska-Kosicka, M., Serban, M., Andreeva, T., Savic, A., Elezovic, I., Mahlangu, J., Tsay, W., Shen, M., Chuansumrit, A., Angchaisuksiri, P., Kavakli, K., Kupesiz, A., Sasmaz, I., Madan, B., Rangarajan, S., Giangrande, P., Saxena, K., Lentz, S., Recht, M., Kempton, C., Barrett, J., Young, G., Quon, D., Stopeck, A., Lin, J., Ameri, A., Kaicker, S., Kuriakose, P., Obzut, D., Wang, M., Ortiz, I. & Sori, A., Jan 1 2014, In : Journal of Thrombosis and Haemostasis. 12, 8, p. 1244-1253 10 p.

Research output: Contribution to journalArticle

Hemophilia A
Randomized Controlled Trials
Hemorrhage
Hemophilia B
Safety
1 Citations

Two new γ chain variants: Hb F-Augusta GA [Gγ59(E3)Lys→Arg; HBG2: C.179A>G] and Hb F-Port Royal-II [Aγ125(H3)Glu→Ala; HBG1: C.377A>C]

Kutlar, F., Ameri, A., Patel, N. H., Zhuang, L., Johnson, L. E., Cheng, M. L. & Kutlar, A., Jan 1 2014, In : Hemoglobin. 38, 5, p. 376-380 5 p.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
gamma-Globins
Molecular Pathology
African Americans
35 Citations

Endogenous factor VIII synthesis from the intron 22-inverted F8 locus may modulate the immunogenicity of replacement therapy for hemophilia A

Pandey, G. S., Yanover, C., Miller-Jenkins, L. M., Garfield, S., Cole, S. A., Curran, J. E., Moses, E. K., Rydz, N., Simhadri, V., Kimchi-Sarfaty, C., Lillicrap, D., Viel, K. R., Przytycka, T. M., Pierce, G. F., Howard, T. E., Sauna, Z. E., Lusher, J., Chitlur, M., Ameri, A., Natrajan, K. & 31 othersIyer, R. V., Thompson, A. A., Watts, R. G., Kempton, C. L., Kessler, C., Barrett, J. C., Martin, E. J., Key, N., Kruse-Jarres, R., Lessinger, C., Pratt, K. P., Josephson, N., McRedmond, K., Withycombe, J., Walsh, C., Matthews, D., Mahlangu, J., Krause, A., Schwyzer, R., Thejpal, R., Rapiti, N., Goga, Y., Coetzee, M., Stones, D., Mann, K., Butenas, S., Almasy, L., Blangero, J., Carless, M., Raja, R. & Reed, E., Oct 1 2013, In : Nature Medicine. 19, 10, p. 1318-1324 7 p.

Research output: Contribution to journalArticle

Factor VIII
Hemophilia A
Introns
Plasmas
T-Lymphocyte Epitopes
6 Citations

Observations regarding the immunogenicity of BDD-rFVIII derived from a mechanistic personalized medicine perspective

Sauna, Z. E., Ameri, A., Kim, B., Yanover, C., Viel, K. R., Rajalingam, R., Cole, S. A. & Howard, T. E., Sep 1 2012, In : Journal of Thrombosis and Haemostasis. 10, 9, p. 1961-1965 5 p.

Research output: Contribution to journalLetter

Precision Medicine
Sequence Deletion
Factor VIII
Recombinant Proteins
Amino Acid Sequence