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Darren D Browning

Professor

  • 2554 Citations
  • 27 h-Index
1991 …2019
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Cyclic GMP-Dependent Protein Kinases Medicine & Life Sciences
Colonic Neoplasms Medicine & Life Sciences
Colon Medicine & Life Sciences
Chemical activation Chemical Compounds
Dictyostelium Medicine & Life Sciences
Formyl Peptide Receptor Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
GTP-Binding Proteins Medicine & Life Sciences

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Projects 2013 2018

Colon Cancer Chemoprevention with Phosphodiesterase-5 Inhibitors

Browning, D. D.

National Institutes of Health

7/1/13 → 4/30/18

Project: Research project

Phosphodiesterase 5 Inhibitors
Chemoprevention
Colonic Neoplasms
Colon
Epithelium

Research Output 1991 2019

  • 2554 Citations
  • 27 h-Index
  • 54 Article
  • 3 Review article
  • 1 Comment/debate
  • 1 Editorial

Indispensable role of the Ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation

Cai, Y., Zhu, G., Liu, S., Pan, Z., Quintero, M., Poole, C. J., Lu, C., Zhu, H., Islam, B., Van Riggelen, J., Browning, D. D., Liu, K., Blumberg, R., Singh, N. & Li, H., Dec 1 2019, In : Cell Discovery. 5, 1, 7.

Research output: Contribution to journal › Article

Ubiquitin-Protein Ligases
Paneth Cells
Ubiquitin
Homeostasis
Inflammation
1 Citations (Scopus)

Clinical utility of plecanatide in the treatment of chronic idiopathic constipation

Islam, B. N., Sharman, S. K. & Browning, D. D., Jan 1 2018, In : International Journal of General Medicine. 11, p. 323-330 8 p.

Research output: Contribution to journal › Review article

Constipation
Pharmaceutical Preparations
Therapeutics
Phosphodiesterase Inhibitors
Enterotoxins
4 Citations (Scopus)

Cyclic-GMP-elevating agents suppress polyposis in Apc Min mice by targeting the preneoplastic epithelium

Sharman, S. K., Islam, B. N., Hou, Y., Singh, N., Berger, F. G., Sridhar, S., Yoo, W. & Browning, D. D., Feb 1 2018, In : Cancer Prevention Research. 11, 2, p. 81-91 11 p.

Research output: Contribution to journal › Article

Cyclic GMP
Polyps
Epithelium
Intestinal Neoplasms
Phosphodiesterase 5 Inhibitors

Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis

Ibrahim, M. L., Klement, J. D., Lu, C., Redd, P. S., Xiao, W., Yang, D., Browning, D. D., Savage, N. M., Buckhaults, P. J., Morse, H. C. & Liu, K., Dec 11 2018, In : Cell Reports. 25, 11, p. 3036-3046.e6

Research output: Contribution to journal › Article

Colitis
Interleukin-10
Colon
Carcinogenesis
Inflammation

Phosphodiesterase-5 inhibitors for colon cancer chemoprevention

Islam, B. N. & Browning, D. D., Sep 1 2018, In : Aging. 10, 9, p. 2216-2217 2 p.

Research output: Contribution to journal › Editorial

Phosphodiesterase 5 Inhibitors
Chemoprevention
Colonic Neoplasms