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David H Munn

Professor

  • 20438 Citations
  • 70 h-Index
1987 …2019
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  • 22 Similar Profiles
Indoleamine-Pyrrole 2,3,-Dioxygenase Medicine & Life Sciences
T-Lymphocytes Medicine & Life Sciences
Dendritic Cells Medicine & Life Sciences
Neoplasms Medicine & Life Sciences
T-cells Chemical Compounds
Regulatory T-Lymphocytes Medicine & Life Sciences
Tryptophan Medicine & Life Sciences
Immunotherapy Medicine & Life Sciences

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Projects 1995 2019

IDO-expressing immunoregulatory dendritic cells

Munn, D. H.

National Institutes of Health

7/1/03 → 5/31/19

Project: Research project › Research Project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Dendritic Cells
T-Lymphocytes
Dioxygenases
Neoplasms

PTEN, Tregs and MDSCs in the tumor microenvironment

Munn, D. H.

Project: Research project

IDO-expressing plasmacytoid dendritic cells and tumors

Munn, D. H.

National Institutes of Health

1/14/05 → 6/30/15

Project: Research project › Research Project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Dendritic Cells
Neoplasms
Neoplasm Antigens
T-Lymphocytes

Role of IDO in Malignancy

Munn, D. H.

National Institutes of Health

7/1/02 → 6/30/17

Project: Research project › Research Project

Indoleamine-Pyrrole 2,3,-Dioxygenase
Neoplasms
Neoplasm Antigens
Drug Therapy
CD40 Ligand

MACROPHAGE MEDIATED IMMUNOREGULATION VIA TRYPTOPHAN

Munn, D. H.

National Institutes of Health

1/1/99 → 12/31/03

Project: Research project › Research Project

Tryptophan
Indoleamine-Pyrrole 2,3,-Dioxygenase
Macrophages
T-Lymphocytes
Macrophage Colony-Stimulating Factor

Research Output 1987 2018

5 Citations

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

Sharma, M. D., Rodriguez, P. C., Koehn, B. H., Baban, B., Cui, Y., Guo, G., Shimoda, M., Pacholczyk, R. W., Shi, H., Lee, E. J., Xu, H., Johnson, T. S., He, Y., Mergoub, T., Venable, C., Bronte, V., Wolchok, J. D., Blazar, B. R. & Munn, D. H., Jan 16 2018, In : Immunity. 48, 1, p. 91-106.e6

Research output: Contribution to journal › Article

Antigen-Presenting Cells
Myeloid Cells
Immunotherapy
Cell Differentiation
Cross-Priming

Alteration of Tumor Metabolism by CD4+ T Cells Leads to TNF-α-Dependent Intensification of Oxidative Stress and Tumor Cell Death

Habtetsion, T., Ding, Z-C., Pi, W., Li, T., Lu, C., Chen, T., Xi, C., Spartz, H., Liu, K., Hao, Z., Mivechi, N. F., Huo, Y., Blazar, B. R., Munn, D. H. & Zhou, G., Aug 7 2018, In : Cell Metabolism. 28, 2, p. 228-242.e6

Research output: Contribution to journal › Article

Oxidative Stress
Cell Death
Tumor Necrosis Factor-alpha
T-Lymphocytes
Adoptive Immunotherapy
8 Citations

Apoptotic cell-induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans article

Shinde, R., Hezaveh, K., Halaby, M. J., Kloetgen, A., Chakravarthy, A., Da Silva Medina, T., Deol, R., Manion, K. P., Baglaenko, Y., Eldh, M., Lamorte, S., Wallace, D., Chodisetti, S. B., Ravishankar, B., Liu, H., Chaudhary, K., Munn, D. H., Tsirigos, A., Madaio, M. P., Gabrielsson, S. & 4 othersTouma, Z., Wither, J., De Carvalho, D. D. & McGaha, T. L., Jun 1 2018, In : Nature Immunology. 19, 6, p. 571-582 12 p.

Research output: Contribution to journal › Article

Systemic Lupus Erythematosus
Phagocytes
Peripheral Tolerance
Pattern Recognition Receptors
DNA

Phase Ia study of the indoleamine 2,3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors

Nayak-Kapoor, A., Hao, Z., Sadek, R., Dobbins, R., Marshall, L., Vahanian, N. N., Jay Ramsey, W., Kennedy, E., Mautino, M. R., Link, C. J., Lin, R. S., Royer-Joo, S., Liang, X., Salphati, L., Morrissey, K. M., Mahrus, S., McCall, B., Pirzkall, A., Munn, D. H., Janik, J. E. & 1 othersKhleif, S. N., Jun 20 2018, In : Journal for ImmunoTherapy of Cancer. 6, 1, 61.

Research output: Contribution to journal › Article

Indoleamine-Pyrrole 2,3,-Dioxygenase
Kynurenine
Half-Life
Neoplasms
Tryptophan
2 Citations

The host protecting the tumor from the host — targeting PD‑L1 expressed by host cells

Munn, D. H., Feb 1 2018, In : Journal of Clinical Investigation. 128, 2, p. 570-572 3 p.

Research output: Contribution to journal › Review article

Ligands
Neoplasms
Death Domain Receptors
Tumor Escape
Immunity