Robert William Caldwell

Professor - Rehired Retiree

  • 5900 Citations
  • 42 h-Index
1970 …2019
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Research Output 1970 2019

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8 Citations (Scopus)

Actions of the opioid antagonist, nalmefene, and congeners on reperfusion cardiac arrhythmias and regional left coronary blood flow

Caldwell, R. W., Nagarajan, R., Chryssanthis, A. & Tuttle, R. R., Jan 1 1990, In : Pharmacology. 41, 3, p. 161-166 6 p.

Research output: Contribution to journalArticle

Narcotic Antagonists
Reperfusion
Cardiac Arrhythmias
Myocardial Reperfusion
Coronary Occlusion
28 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Blood Vessels
Nitrergic Neurons
10 Citations (Scopus)

Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy

Patel, C., Narayanan, S. P., Zhang, W., Xu, Z., Sukumari Ramesh, S., Dhandapani, K. M., Caldwell, R. W. & Caldwell, R. B., Jan 1 2014, In : American Journal of Pathology. 184, 11, p. 3040-3051 12 p.

Research output: Contribution to journalArticle

Pathologic Neovascularization
Endothelins
Oxygen
Physiologic Neovascularization
Vascular Endothelial Growth Factor A
23 Citations (Scopus)

Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx

Datar, R., Kaesemeyer, W. H., Chandra, S., Fulton, D. J. & Caldwell, R. W., Aug 1 2010, In : British Journal of Pharmacology. 160, 7, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

Gi-Go GTP-Binding Protein alpha Subunits
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Scavenger Receptors
Nitric Oxide Synthase Type III
Type C Phospholipases

Acute cardiovascular and autonomic effects of the S 2 (3 amino propylamine) ethyl phosphorothioic acid (WR 2721)

Caldwell, R. W. & Heiffer, M. H., Jan 1 1973, In : Radiation Research. 55, 3, 1 p.

Research output: Contribution to journalArticle

acids
9 Citations (Scopus)

Acute cardiovascular and autonomic effects of WR 2721: a radioprotective compound

Caldwell, R. W. & Heiffer, M. H., Jan 1 1975, In : RADIAT.RES.. 62, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

Autonomic Agents
Amifostine
dogs
cats
vasoconstrictor drugs
12 Citations (Scopus)

Adrenergic and cholinergic mechanisms in digitalis inotrophy

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 233, 3, p. 761-765 5 p.

Research output: Contribution to journalArticle

Digitoxigenin
Cardiac Glycosides
Digitalis
Adrenergic Agents
Cholinergic Agents
19 Citations (Scopus)

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

Arginase
arginase
blood vessels
Blood Vessels
Medical problems

Alpha-adrenergic blocking action of quinine

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., Jan 1 1979, In : Federation Proceedings. 38, 3 I

Research output: Contribution to journalArticle

Quinine
Adrenergic Agents
20 Citations (Scopus)

Amidative peptide processing and vascular function

Oldham, C. D., Li, C., Feng, J., Scott, R. O., Wang, W. Z., Moore, A. B., Girard, P. R., Huang, J., Caldwell, R. B., William Caldwell, R. & May, S. W., Dec 1 1997, In : American Journal of Physiology - Cell Physiology. 273, 6 42-6

Research output: Contribution to journalArticle

Substance P
Blood Vessels
Endothelial cells
Peptides
Nitric Oxide Synthase
8 Citations (Scopus)

An evaluation of the vasodilation produced by mephentermine and certain other sympathomimetic amines.

Caldwell, R. W. & Goldberg, L. I., Apr 1 1970, In : Journal of Pharmacology and Experimental Therapeutics. 172, 2, p. 297-309 13 p.

Research output: Contribution to journalArticle

Mephentermine
Metaraminol
Histamine H1 Antagonists
Ephedrine
Phenoxybenzamine
13 Citations (Scopus)

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Flores Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In : PloS one. 10, 3, e0121727.

Research output: Contribution to journalArticle

Arginase
arginase
angiotensin II
fibrosis
Angiotensin II
83 Citations (Scopus)
Arginase
rho-Associated Kinases
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Blood Vessels
24 Citations (Scopus)

Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway

Shatanawi, A., Lemtalsi, T., Yao, L., Patel, C., Caldwell, R. B. & Caldwell, R. W., Jan 5 2015, In : European Journal of Pharmacology. 746, p. 106-114 9 p.

Research output: Contribution to journalArticle

Arginase
Mitogen-Activated Protein Kinase 1
p38 Mitogen-Activated Protein Kinases
Angiotensin II
Nitric Oxide
2 Citations (Scopus)

A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent

Nagarajan, R., Abou-Mohamed, G., Myers, T. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

Catecholamines
Dobutamine
Pharmacology
Vascular Resistance
Dogs
8 Citations (Scopus)

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., Sep 16 2013, In : Frontiers in immunology. 4, AUG, Article 228.

Research output: Contribution to journalArticle

Arginase
Acute Lung Injury
Nitric Oxide Synthase Type III
Bacterial Toxins
Lung
24 Citations (Scopus)
Arginase
Desoxycorticosterone
Blood Vessels
Acetates
Salts
3 Citations (Scopus)

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

Arginase
Ischemia
Macrophages
Reperfusion Injury
Knockout Mice
17 Citations (Scopus)

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration

Suwanpradid, J., Rojas, M., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Nov 6 2014, In : PloS one. 9, 11, 110604.

Research output: Contribution to journalArticle

Hyperargininemia
hyperoxia
Arginase
arginase
Retinal Vessels
22 Citations (Scopus)

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Narayanan, S. P., Xu, Z., Putluri, N., Sreekumar, A., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Feb 1 2014, In : Cell Death and Disease. 5, 2, e1075.

Research output: Contribution to journalArticle

Hyperargininemia
Hyperoxia
Polyamines
Oxygen
Retina
36 Citations (Scopus)

Arginase 2 deletion reduces Neuro-Glial injury and improves retinal function in a model of Retinopathy of prematurity

Narayanan, S. P., Suwanpradid, J., Saul, A., Xu, Z., Still, A., Caldwell, R. W. & Caldwell, R. B., Jul 27 2011, In : PloS one. 6, 7, e22460.

Research output: Contribution to journalArticle

premature birth
Arginase
retinal diseases
arginase
Retinopathy of Prematurity
13 Citations (Scopus)

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

Arginase
Reperfusion Injury
Ischemia
Reperfusion
Electroretinography
44 Citations (Scopus)

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis

Zhang, W., Baban, B., Rojas, M. A., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero Lucas, M. J., Caldwell, R. W. & Caldwell, R. B., Jan 1 2009, In : American Journal of Pathology. 175, 2, p. 891-902 12 p.

Research output: Contribution to journalArticle

Arginase
Uveitis
Endotoxins
Inflammation
Lipopolysaccharides
25 Citations (Scopus)

Arginase as a mediator of diabetic retinopathy

Patel, C., Rojas, M., Narayanan, S. P., Zhang, W., Xu, Z., Lemtalsi, T., Jittiporn, K., Caldwell, R. W. & Caldwell, R. B., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 173.

Research output: Contribution to journalArticle

Arginase
Diabetic Retinopathy
Retinal Vessels
Retina
Glucose
45 Citations (Scopus)

Arginase II deletion increases corpora cavernosa relaxation in diabetic mice

Flores Toque, H. A., Tostes, R. C., Yao, L., Xu, Z., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2011, In : Journal of Sexual Medicine. 8, 3, p. 722-733 12 p.

Research output: Contribution to journalArticle

Arginase
Knockout Mice
Endothelium
Erectile Dysfunction
Experimental Diabetes Mellitus
9 Citations (Scopus)

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

Arginase
Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Hypoxia
36 Citations (Scopus)

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

Arginase
Polyamines
Superoxides
Glutamic Acid
Peroxynitrous Acid
1 Citation (Scopus)

ASI-222 and ASI-254

Caldwell, R. W., Jan 1 1982, In : Drugs of the Future. 7, 10, p. 719-721 3 p.

Research output: Contribution to journalArticle

ASI-222
ASI 254
67 Citations (Scopus)

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

Calpain
Pulmonary Hypertension
Rodentia
Lung
Epidermal Growth Factor

Cardiac effects of ASI 222 HCl, a new cardiac glycoside

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Federation Proceedings. 35, 3

Research output: Contribution to journalArticle

Cardiac Glycosides
ASI-222

Cardiopulmonary effects of I.V. quinine HCL (Q)

Caldwell, R. W. & Nash, C. B., Jan 1 1978, In : Federation Proceedings. 37, 3

Research output: Contribution to journalArticle

Quinine

Cardiopulmonary effects of mefloquine CH3SO3H (MMS)

Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Pharmacologist. 18, 2

Research output: Contribution to journalArticle

Mefloquine
3 Citations (Scopus)
Cardiotonic Agents
Dobutamine
High Pressure Liquid Chromatography
Plasmas
Pharmaceutical Preparations
1 Citation (Scopus)

Cardiovascular effect of new 4 amino sugar cardiac glycosides (ASI-222 and ASI-222 HCl)

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Clinical Research. 24, 4

Research output: Contribution to journalArticle

Amino Sugars
Cardiac Glycosides
ASI-222
32 Citations (Scopus)

Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

Rockhold, R. W. & Caldwell, R. W., Jan 1 1980, In : Neuropharmacology. 19, 9, p. 919-922 4 p.

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
Microinjections
Blood Pressure
Yohimbine

Cardiovascular effects of clonidine (C) following lesions of the nucleus tractus solitarius (NTS)

Rockhold, R. W., Caldwell, R. W. & Lawson, J. W., Jan 1 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
5 Citations (Scopus)

Cardiovascular effects of KM-13, a new, orally effective, cardiotonic sympathomimetic amine

Caldwell, R. W., Nash, C. B., Smulkowski, M. & Tuttle, R. R., Jan 1 1987, In : Journal of Cardiovascular Pharmacology. 9, 3, p. 375-384 10 p.

Research output: Contribution to journalArticle

Cardiotonic Agents
Sympathomimetics
Dobutamine
Blood Pressure
Buccal Administration
1 Citation (Scopus)

Cardiovascular responses to perfusion of the nucleus tractus solitarii (NTS) with clonidine (C)

Rockhold, R. W. & Caldwell, R. W., Jan 1 1976, In : Federation Proceedings. 35, 3

Research output: Contribution to journalArticle

Solitary Nucleus
Clonidine
Perfusion
41 Citations (Scopus)

Certain norditerpenoid alkaloids and their cardiovascular action

Desai, H. K., Hart, B. P., Caldwell, R. W., Jianzhong-Huang & Pelletier, S. W., Jun 1 1998, In : Journal of Natural Products. 61, 6, p. 743-748 6 p.

Research output: Contribution to journalArticle

diterpenoid alkaloids
Diterpenes
Alkaloids
Oxides
oxides
10 Citations (Scopus)

Changes in cardiac glycoside activity produced by aminosugar addition

Cook, L. S., Caldwell, R. W. & Nash, C. B., Dec 1 1980, In : Journal of Pharmacology and Experimental Therapeutics. 215, 1, p. 198-204 7 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digitoxigenin
Poisons
Cardenolides
Cardiotonic Agents

Changes in therapeutic index and cardiac effects by aminogalactose substitution on digitoxigenin

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1977, In : Pharmacologist. 19, 2

Research output: Contribution to journalArticle

Digitoxigenin
Therapeutics
6 Citations (Scopus)

Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing

Abou-Mohamed, G., Nagarajan, R., Ibrahim, T. M. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

Adrenergic Agents
Pharmacology
Isoproterenol
Adrenergic Receptors
arbutamine

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

Oxidative Stress
Anxiety
Anxiety Disorders
Pyramidal Cells
NADP
8 Citations (Scopus)

Comparative ability of digoxin and an aminosugar cardiac glycoside to bind to and inhibit Na+,K+-adenosine triphosphatase. Effect of potassium

Songu-Mize, E., Gunter, J. L. & Caldwell, R. W., Nov 1 1989, In : Biochemical Pharmacology. 38, 21, p. 3689-3695 7 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Adenosine Triphosphatases
Potassium
Potassium Chloride
1 Citation (Scopus)
Cardenolides
Halothane
Ouabain
1 Citation (Scopus)
Cardiac Glycosides
Digoxin
Ouabain
sodium-translocating ATPase

Comparison of a 4 aminosugar cardiac glycoside with digoxin in the heart lung preparation

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Pharmacologist. 18, 2, p. No.053

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Lung
6 Citations (Scopus)

Comparison of the cardiac effects of ASI 222 HCl, an aminosugar cardiac glycoside, and digoxin

Cook, L. S., Caldwell, R. W. & Nash, C. B., Dec 1 1977, In : Archives Internationales de Pharmacodynamie et de Therapie. 227, 2, p. 220-232 13 p.

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Dogs
Rabbits
Vagotomy
10 Citations (Scopus)
Cardiac Glycosides
Digoxin
Ouabain
Adenosine Triphosphatases
Glycosides
1 Citation (Scopus)

Comparison of the therapeutic index (TI) of aminosugar cardiac glycosides with digoxin (D)

Caldwell, R. W. & Nash, C. B., Jan 1 1977, In : Federation Proceedings. 36, 3

Research output: Contribution to journalArticle

Cardiac Glycosides
Digoxin
Therapeutics