Robert William Caldwell

Professor - Rehired Retiree

  • 6357 Citations
  • 44 h-Index
1970 …2020

Research output per year

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Research Output

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Actions of the opioid antagonist, nalmefene, and congeners on reperfusion cardiac arrhythmias and regional left coronary blood flow

Caldwell, R. W., Nagarajan, R., Chryssanthis, A. & Tuttle, R. R., Jan 1 1990, In : Pharmacology. 41, 3, p. 161-166 6 p.

Research output: Contribution to journalArticle

8 Scopus citations
32 Scopus citations

Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy

Patel, C., Narayanan, S. P., Zhang, W., Xu, Z., Sukumari Ramesh, S., Dhandapani, K. M., Caldwell, R. W. & Caldwell, R. B., Jan 1 2014, In : American Journal of Pathology. 184, 11, p. 3040-3051 12 p.

Research output: Contribution to journalArticle

12 Scopus citations

Acute activation of eNOS by statins involves scavenger receptor-B1, G protein subunit Gi, phospholipase C and calcium influx

Datar, R., Kaesemeyer, W. H., Chandra, S., Fulton, D. J. & Caldwell, R. W., Aug 1 2010, In : British Journal of Pharmacology. 160, 7, p. 1765-1772 8 p.

Research output: Contribution to journalArticle

25 Scopus citations

Acute cardiovascular and autonomic effects of the S 2 (3 amino propylamine) ethyl phosphorothioic acid (WR 2721)

Caldwell, R. W. & Heiffer, M. H., Jan 1 1973, In : Radiation research. 55, 3, 1 p.

Research output: Contribution to journalArticle

Acute cardiovascular and autonomic effects of WR 2721: a radioprotective compound

Caldwell, R. W. & Heiffer, M. H., Jan 1 1975, In : RADIAT.RES.. 62, 1, p. 62-69 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Adrenergic and cholinergic mechanisms in digitalis inotrophy

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1982, In : Journal of Pharmacology and Experimental Therapeutics. 233, 3, p. 761-765 5 p.

Research output: Contribution to journalArticle

12 Scopus citations

Age-dependent oxidative stress elevates arginase 1 and uncoupled nitric oxide synthesis in skeletal muscle of aged mice

Pandya, C. D., Lee, B., Toque, H. A., Mendhe, B., Bragg, R. T., Pandya, B., Atawia, R. T., Isales, C., Hamrick, M., Caldwell, R. W. & Fulzele, S., 2019, In : Oxidative medicine and cellular longevity. 2019, 1704650.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Akita spontaneously type 1 diabetic mice exhibit elevated vascular arginase and impaired vascular endothelial and nitrergic function

Toque, H. A., Nunes, K. P., Yao, L., Xu, Z., Kondrikov, D., Su, Y., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Jan 1 2013, In : PloS one. 8, 8, p. e72277

Research output: Contribution to journalArticle

20 Scopus citations

Alpha-adrenergic blocking action of quinine

Mecca, T. E., Elam, J. T., Nash, C. B. & Caldwell, R. W., Jan 1 1979, In : Federation Proceedings. 38, 3 I, p. No.130

Research output: Contribution to journalArticle

Amidative peptide processing and vascular function

Oldham, C. D., Li, C., Feng, J., Scott, R. O., Wang, W. Z., Moore, A. B., Girard, P. R., Huang, J., Caldwell, R. B., William Caldwell, R. & May, S. W., Dec 1 1997, In : American Journal of Physiology - Cell Physiology. 273, 6 42-6, p. C1908-C1914

Research output: Contribution to journalArticle

20 Scopus citations

An evaluation of the vasodilation produced by mephentermine and certain other sympathomimetic amines.

Caldwell, R. W. & Goldberg, L. I., Apr 1 1970, In : Journal of Pharmacology and Experimental Therapeutics. 172, 2, p. 297-309 13 p.

Research output: Contribution to journalArticle

8 Scopus citations

Angiotensin II-induced arterial thickening, fibrosis and stiffening involves elevated arginase function

Bhatta, A., Yao, L., Toque, H. A., Shatanawi, A., Xu, Z., Caldwell, R. B. & Caldwell, R. W., Mar 25 2015, In : PloS one. 10, 3, e0121727.

Research output: Contribution to journalArticle

17 Scopus citations
90 Scopus citations

Angiotensin II limits NO production by upregulating arginase through a p38 MAPK-ATF-2 pathway

Shatanawi, A., Lemtalsi, T., Yao, L., Patel, C., Caldwell, R. B. & Caldwell, R. W., Jan 5 2015, In : European Journal of Pharmacology. 746, p. 106-114 9 p.

Research output: Contribution to journalArticle

28 Scopus citations

A novel catecholamine, arbutamine, for a pharmacological cardiac stress agent

Nagarajan, R., Abou-Mohamed, G., Myers, T. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 31-38 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Arginase 1: An unexpected mediator of pulmonary capillary barrier dysfunction in models of acute lung injury

Lucas, R., Czikora, I., Sridhar, S., Zemskov, E. A., Oseghale, A., Circo, S., Cederbaum, S. D., Chakraborty, T., Fulton, D. J., Caldwell, R. W. & Romero Lucas, M. J., Sep 16 2013, In : Frontiers in immunology. 4, AUG, Article 228.

Research output: Contribution to journalArticle

10 Scopus citations

Arginase 1 mediates increased blood pressure and contributes to vascular endothelial dysfunction in deoxycorticosterone acetate-salt hypertension

Toque, H. A., Nunes, K. P., Rojas, M., Bhatta, A., Yao, L., Xu, Z., Romero, M. J., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 219.

Research output: Contribution to journalArticle

29 Scopus citations

Arginase 1 promotes retinal neurovascular protection from ischemia through suppression of macrophage inflammatory responses

Fouda, A. Y., Xu, Z., Shosha, E., Lemtalsi, T., Chen, J., Toque, H. A., Tritz, R., Cui, X., Stansfield, B. K., Huo, Y., Rodriguez, P. C., Smith, S. B., Caldwell, R. W., Narayanan, S. P. & Caldwell, R. B., Oct 1 2018, In : Cell Death and Disease. 9, 10, 1001.

Research output: Contribution to journalArticle

6 Scopus citations

Arginase 2 deficiency prevents oxidative stress and limits hyperoxia-induced retinal vascular degeneration

Suwanpradid, J., Rojas, M., Behzadian, M. A., Caldwell, R. W. & Caldwell, R. B., Nov 6 2014, In : PloS one. 9, 11, 110604.

Research output: Contribution to journalArticle

20 Scopus citations

Arginase 2 deficiency reduces hyperoxia-mediated retinal neurodegeneration through the regulation of polyamine metabolism

Narayanan, S. P., Xu, Z., Putluri, N., Sreekumar, A., Lemtalsi, T., Caldwell, R. W. & Caldwell, R. B., Feb 1 2014, In : Cell Death and Disease. 5, 2, e1075.

Research output: Contribution to journalArticle

25 Scopus citations

Arginase 2 deletion reduces Neuro-Glial injury and improves retinal function in a model of Retinopathy of prematurity

Narayanan, S. P., Suwanpradid, J., Saul, A., Xu, Z., Still, A., Caldwell, R. W. & Caldwell, R. B., 2011, In : PloS one. 6, 7, e22460.

Research output: Contribution to journalArticle

37 Scopus citations

Arginase 2 promotes neurovascular degeneration during ischemia/reperfusion injury

Shosha, E., Xu, Z., Yokota, H., Saul, A., Rojas, M., William Caldwell, R., Caldwell, R. B. & Priya Narayanan, S., Jan 1 2016, In : Cell Death and Disease. 7, 11, e2483.

Research output: Contribution to journalArticle

18 Scopus citations

Arginase activity mediates retinal inflammation in endotoxin-induced uveitis

Zhang, W., Baban, B., Rojas, M., Tofigh, S., Virmani, S. K., Patel, C., Behzadian, M. A., Romero, M. J., Caldwell, R. W. & Caldwell, R. B., Aug 2009, In : American Journal of Pathology. 175, 2, p. 891-902 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Arginase as a mediator of diabetic retinopathy

Patel, C., Rojas, M., Narayanan, S. P., Zhang, W., Xu, Z., Lemtalsi, T., Jittiporn, K., Caldwell, R. W. & Caldwell, R. B., Sep 16 2013, In : Frontiers in immunology. 4, JUL, Article 173.

Research output: Contribution to journalArticle

26 Scopus citations

Arginase II deletion increases corpora cavernosa relaxation in diabetic mice

Toque, H. A., Tostes, R. C., Yao, L., Xu, Z., Webb, R. C., Caldwell, R. B. & Caldwell, R. W., Mar 2011, In : Journal of Sexual Medicine. 8, 3, p. 722-733 12 p.

Research output: Contribution to journalArticle

46 Scopus citations

Arginase inhibition enhances angiogenesis in endothelial cells exposed to hypoxia

Wang, L., Bhatta, A., Flores Toque, H. A., Rojas, M. A., Yao, L., Xu, Z., Patel, C., Caldwell, R. B. & Caldwell, R. W., Mar 1 2015, In : Microvascular Research. 98, p. 1-8 8 p.

Research output: Contribution to journalArticle

12 Scopus citations

Arginase in retinopathy

Narayanan, S. P., Rojas, M., Suwanpradid, J., Toque, H. A., Caldwell, R. W. & Caldwell, R. B., Sep 1 2013, In : Progress in Retinal and Eye Research. 36, p. 260-280 21 p.

Research output: Contribution to journalArticle

41 Scopus citations

ASI-222 and ASI-254

Caldwell, R. W., Jan 1 1982, In : Drugs of the Future. 7, 10, p. 719-721 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease

Ma, W., Han, W., Greer, P. A., Tuder, R. M., Toque, H. A., Wang, K. K. W., Caldwell, R. W. & Su, Y., Nov 1 2011, In : Journal of Clinical Investigation. 121, 11, p. 4548-4566 19 p.

Research output: Contribution to journalArticle

70 Scopus citations

Cardiac effects of ASI 222 HCl, a new cardiac glycoside

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Federation Proceedings. 35, 3, p. no. 1222

Research output: Contribution to journalArticle

Cardiopulmonary effects of I.V. quinine HCL (Q)

Caldwell, R. W. & Nash, C. B., Jan 1 1978, In : Federation Proceedings. 37, 3

Research output: Contribution to journalArticle

Cardiopulmonary effects of mefloquine CH3SO3H (MMS)

Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Pharmacologist. 18, 2

Research output: Contribution to journalArticle

3 Scopus citations

Cardiovascular effect of new 4 amino sugar cardiac glycosides (ASI-222 and ASI-222 HCl)

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Clinical Research. 24, 4, p. 604A

Research output: Contribution to journalArticle

1 Scopus citations

Cardiovascular effects following clonidine microinjection into the nucleus tractus solitarii of the rat

Rockhold, R. W. & Caldwell, R. W., Jan 1 1980, In : Neuropharmacology. 19, 9, p. 919-922 4 p.

Research output: Contribution to journalArticle

33 Scopus citations

Cardiovascular effects of clonidine (C) following lesions of the nucleus tractus solitarius (NTS)

Rockhold, R. W., Caldwell, R. W. & Lawson, J. W., Jan 1 1977, In : Federation Proceedings. 36, 3, p. No. 1564

Research output: Contribution to journalArticle

Cardiovascular effects of KM-13, a new, orally effective, cardiotonic sympathomimetic amine

Caldwell, R. W., Nash, C. B., Smulkowski, M. & Tuttle, R. R., Jan 1 1987, In : Journal of Cardiovascular Pharmacology. 9, 3, p. 375-384 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cardiovascular responses to perfusion of the nucleus tractus solitarii (NTS) with clonidine (C)

Rockhold, R. W. & Caldwell, R. W., Jan 1 1976, In : Federation Proceedings. 35, 3

Research output: Contribution to journalArticle

1 Scopus citations

Certain norditerpenoid alkaloids and their cardiovascular action

Desai, H. K., Hart, B. P., Caldwell, R. W., Jianzhong-Huang & Pelletier, S. W., Jun 1 1998, In : Journal of Natural Products. 61, 6, p. 743-748 6 p.

Research output: Contribution to journalArticle

41 Scopus citations

Changes in cardiac glycoside activity produced by aminosugar addition

Cook, L. S., Caldwell, R. W. & Nash, C. B., Dec 1 1980, In : Journal of Pharmacology and Experimental Therapeutics. 215, 1, p. 198-204 7 p.

Research output: Contribution to journalArticle

10 Scopus citations

Changes in therapeutic index and cardiac effects by aminogalactose substitution on digitoxigenin

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1977, In : Pharmacologist. 19, 2, p. No. 026

Research output: Contribution to journalArticle

Characterization of the adrenergic activity of arbutamine, a novel agent for pharmacological stress testing

Abou-Mohamed, G., Nagarajan, R., Ibrahim, T. M. & Caldwell, R. W., Jan 1 1996, In : Cardiovascular Drugs and Therapy. 10, 1, p. 39-47 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Chronic mild stress induced anxiety-like behaviors can Be attenuated by inhibition of NOX2-derived oxidative stress

Lv, H., Zhu, C., Wu, R., Ni, H., Lian, J., Xu, Y., Xia, Y., Shi, G., Li, Z., Caldwell, R. B., Caldwell, R. W., Yao, L. & Chen, Y., Jul 2019, In : Journal of Psychiatric Research. 114, p. 55-66 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

Comparative ability of digoxin and an aminosugar cardiac glycoside to bind to and inhibit Na+,K+-adenosine triphosphatase. Effect of potassium

Songu-Mize, E., Gunter, J. L. & Caldwell, R. W., Nov 1 1989, In : Biochemical Pharmacology. 38, 21, p. 3689-3695 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Comparative inotropic activity of ouabain (O) and an amino-cardenolide (AC) in the halothane (H) depressed heart

Heerdt, P. M. & Caldwell, R. W., Jan 1 1984, In : Federation Proceedings. 43, 4, p. no. 4439

Research output: Contribution to journalArticle

1 Scopus citations
1 Scopus citations

Comparison of a 4 aminosugar cardiac glycoside with digoxin in the heart lung preparation

Cook, L. S., Caldwell, R. W. & Nash, C. B., Jan 1 1976, In : Pharmacologist. 18, 2, p. No.053

Research output: Contribution to journalArticle

Comparison of the cardiac effects of ASI 222 HCl, an aminosugar cardiac glycoside, and digoxin

Cook, L. S., Caldwell, R. W. & Nash, C. B., Dec 1 1977, In : Archives Internationales de Pharmacodynamie et de Therapie. 227, 2, p. 220-232 13 p.

Research output: Contribution to journalArticle

6 Scopus citations
10 Scopus citations