• 236 Citations
  • 7 h-Index
20022019
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Research Output 2002 2019

  • 236 Citations
  • 7 h-Index
  • 16 Article
  • 2 Letter
  • 1 Review article
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Article
2019
1 Citation (Scopus)

Conjugate prodrug AN-233 induces fetal hemoglobin expression in sickle erythroid progenitors and β-YAC transgenic mice

Oseghale, A. R., Zhu, X., Li, B., Peterson, K. R., Nudelman, A., Rephaeli, A., Xu, H. & Pace, B. S., Nov 1 2019, In : Blood Cells, Molecules, and Diseases. 79, 102345.

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Prodrugs
Transgenic Mice
Sickle Cell Anemia
6 Citations (Scopus)

MIR-144-mediated NRF2 gene silencing inhibits fetal hemoglobin expression in sickle cell disease

Li, B., Zhu, X., Ward, C. M., Starlard-Davenport, A., Takezaki, M., Berry, A., Ward, A., Wilder, C., Neunert, C., Kutlar, A. & Pace, B. S., Feb 1 2019, In : Experimental Hematology. 70, p. 85-96.e5

Research output: Contribution to journalArticle

Fetal Hemoglobin
Globins
Sickle Cell Anemia
Gene Silencing
MicroRNAs
2018
9 Citations (Scopus)

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Zhu, X., Xi, C., Thomas, B. & Pace, B. S., Feb 1 2018, In : Blood. 131, 5, p. 558-562 5 p.

Research output: Contribution to journalArticle

Sickle Cell Anemia
Transgenic Mice
Fetal Hemoglobin
Oxidative stress
Reactive Oxygen Species
2017
1 Citation (Scopus)

Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with index of hydroxyurea responsiveness

Zhu, X., Hu, T., Ho, M. H., Wang, Y., Yu, M., Patel, N., Pi, W., Choi, J-H., Xu, H., Ganapathy, V., Kutlar, F., Kutlar, A. & Tuan Lo, D., Nov 30 2017, In : Haematologica. 102, 12, p. 1995-2004 10 p.

Research output: Contribution to journalArticle

Erythroblasts
Hydroxyurea
Globins
Sickle Cell Anemia
Genes
5 Citations (Scopus)

Hypermethylated LTR retrotransposon exhibits enhancer activity

Hu, T., Zhu, X., Pi, W., Yu, M., Shi, H. & Tuan Lo, D., Mar 4 2017, In : Epigenetics. 12, 3, p. 226-237 12 p.

Research output: Contribution to journalArticle

Retroelements
Endogenous Retroviruses
Globins
Genes
DNA
6 Citations (Scopus)

Long non-coding RNAs transcribed by ERV-9 LTR retrotransposon act in cis to modulate long-range LTR enhancer function

Hu, T., Pi, W., Zhu, X., Yu, M., Ha, H., Shi, H., Choi, J-H. & Tuan Lo, D., Jan 1 2017, In : Nucleic Acids Research. 45, 8, p. 4479-4492 14 p.

Research output: Contribution to journalArticle

Long Noncoding RNA
Endogenous Retroviruses
Retroelements
Erythroblasts
Globins
2012
21 Citations (Scopus)

NF-Y Recruits Both Transcription Activator and Repressor to Modulate Tissue- and Developmental Stage-Specific Expression of Human γ-Globin Gene

Zhu, X., Wang, Y., Pi, W., Liu, H., Wickrema, A. & Tuan Lo, D., Oct 10 2012, In : PloS one. 7, 10, e47175.

Research output: Contribution to journalArticle

Globins
Transcription
Erythroid Cells
transcription (genetics)
Genes
2010
48 Citations (Scopus)

Long-range function of an intergenic retrotransposon

Pi, W., Zhu, X., Wu, M., Wang, Y., Fulzele, S. T., Eroglu, A., Ling, J. & Tuan Lo, D., Jul 20 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 29, p. 12992-12997 6 p.

Research output: Contribution to journalArticle

Retroelements
Terminal Repeat Sequences
Endogenous Retroviruses
Globins
Genes
2008
5 Citations (Scopus)

Evaluation of Glu11 and Gly8 of the H5N1 influenza hemagglutinin fusion peptide in membrane fusion using pseudotype virus and reverse genetics

Su, Y., Zhu, X., Wang, Y., Wu, M. & Tien, P., Feb 1 2008, In : Archives of Virology. 153, 2, p. 247-257 11 p.

Research output: Contribution to journalArticle

Reverse Genetics
Membrane Fusion
Hemagglutinins
Human Influenza
Viruses
2007
60 Citations (Scopus)

A facilitated tracking and transcription mechanism of long-range enhancer function

Zhu, X., Ling, J., Zhang, L., Pi, W., Wu, M. & Tuan Lo, D., Aug 1 2007, In : Nucleic Acids Research. 35, 16, p. 5532-5544 13 p.

Research output: Contribution to journalArticle

Globins
DNA
DNA Polymerase II
Locus Control Region
Genes
2005
35 Citations (Scopus)

The long terminal repeat (LTR) of ERV-9 human endogenous retrovirus binds to NF-Y in the assembly of an active LTR enhancer complex NF-Y/MZF1/GATA-2

Yu, X., Zhu, X., Pi, W., Ling, J., Ko, L., Takeda, Y. & Tuan Lo, D., Oct 21 2005, In : Journal of Biological Chemistry. 280, 42, p. 35184-35194 11 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Terminal Repeat Sequences
Erythroid Cells
Nucleotide Motifs
Globins
2004

Binding of trans-acting protein AngCP to the CCAAT-containing motifs in Aspergillus niger glaA promoter

Zhu, X., Qiu, R., Liu, L. & Tang, G., Jan 1 2004, In : Progress in Natural Science. 14, 4, p. 338-343 6 p.

Research output: Contribution to journalArticle

Aspergillus
Gels
Genes
Proteins
Affinity chromatography
3 Citations (Scopus)

The synergetic effects of two CCAAT boxes in Aspergillus niger glaA gene promoter on activation of PglaA transcription

Zhu, X., Wang, H. M., Qiu, R., Liu, L., Dong, Z. & Tang, G., Dec 1 2004, In : Science in China, Series C: Life Sciences. 47, 2, p. 139-147 9 p.

Research output: Contribution to journalArticle

Aspergillus niger
Aspergillus
transcriptional activation
Transcription
Transcriptional Activation
2003
18 Citations (Scopus)

Improving heterologous gene expression in Aspergillus niger by introducing multiple copies of protein-binding sequence containing CCAAT to the promoter

Liu, L., Liu, J., Qiu, R. X., Zhu, X., Dong, Z. Y. & Tang, G. M., Jun 12 2003, In : Letters in Applied Microbiology. 36, 6, p. 358-361 4 p.

Research output: Contribution to journalArticle

Aspergillus niger
Protein Binding
Gene Expression
Binding Sites
Genes
2002
1 Citation (Scopus)

Construction of recipient strain of expression-secretion system in filamentous fungi

Liu, L., Liu, J., Qiu, R. X., Zhu, X. & Tang, G. M., Jan 1 2002, In : Sheng wu gong cheng xue bao = Chinese journal of biotechnology. 18, 6, p. 667-670 4 p.

Research output: Contribution to journalArticle

Peptide Hydrolases
Fungi
Glucan 1,4-alpha-Glucosidase
Acids
Caseins
4 Citations (Scopus)

Detection of a protein, AngCP, which binds specifically to the three upstream regions of glaA gene in A. niger T21

Qiu, R., Zhu, X., Liu, L. & Tang, G., Dec 1 2002, In : Science in China, Series C: Life Sciences. 45, 5, p. 527-537 11 p.

Research output: Contribution to journalArticle

Aspergillus niger
Aspergillus
Genes
protein
gene