GENERAL CLINICAL RESEARCH CENTER

  • Cannon, Joseph Gerard, (PI)
  • Dinarello, Charles (PI)
  • Hollander, David (PI)
  • Cole, Cynthia (PI)
  • Lechan, Ronald Michael (PI)
  • Streeter, Chris (PI)
  • Fulwiler, Carl (PI)
  • Freeman, Richard (PI)
  • Greenberg, Andrew (PI)
  • Ciraulo, Domenic Anthony (PI)
  • Barnett, Junaidah (PI)
  • Konstam, Marvin (PI)
  • Lee, Young (PI)
  • Selker, Harry (PI)
  • Carr, Daniel (PI)
  • Cole, Cynthia Hamlet (PI)
  • Tsunoda, Shirley (PI)
  • Udelson, James (PI)
  • Wanke, Christine (PI)
  • Shevitz, Abby (PI)
  • Bianchi, Diana (PI)
  • Roberts, Susan (PI)
  • Ehrenberg, B. (PI)
  • Klempner, Mark (PI)
  • Smith, John (PI)
  • Haewok, Han (PI)
  • [No Value], L.K. George (PI)
  • Lee, Stephanie (PI)
  • Sukiennik, Andrew (PI)
  • Kaplan, Marshall (PI)
  • Skolnik, Paul (PI)
  • Freeman, Richard (PI)
  • Carr, Daniel (PI)
  • Cole, Cynthia Hamlet (PI)
  • Tsunoda, Shirley (PI)
  • Greenberg, Andrew (PI)
  • Schaefer, Ernst John (PI)
  • Ciraulo, Domenic Anthony (PI)
  • Udelson, James (PI)
  • Goldin, Barry (PI)
  • Barnett, Junaidah (PI)
  • Woods, Margo (PI)
  • Konstam, Marvin A. (PI)
  • Smith, John (PI)
  • Lee, Young (PI)
  • Wolfe, Hubert (PI)
  • Wanke, Christine (PI)
  • Roubenoff, Ronenn (PI)
  • Greenblatt, David (PI)
  • Gorbach, Sherwood (PI)
  • Shevitz, Abby (PI)
  • Haewok, Han (PI)
  • Bianchi, Diana (PI)
  • [No Value], L.K. George (PI)
  • Lee, Stephanie (PI)
  • Klempner, Mark (PI)
  • Cole, Cynthia Hamlet (PI)
  • Wang, Chenchen (PI)
  • Folstein, Marshal F. (PI)
  • Pittas, Anastassios (PI)
  • Greenblatt, David (PI)
  • Long, John (PI)
  • Schaefer, Ernst John (PI)
  • Udelson, James (PI)
  • Barnett, Junaidah (PI)
  • Woods, Margo (PI)
  • Sarnak, Mark (PI)
  • Lee, Young (PI)
  • Wilson, Ira (PI)
  • Forrester, Janet (PI)
  • Gorbach, Sherwood (PI)
  • Shevitz, Abby (PI)
  • Bianchi, Diana (PI)
  • Snydman, David Richard (PI)
  • Hibberd, Patricia (PI)
  • Dansinger, Michael (PI)
  • Wanke, Christine (PI)
  • Menon, Vandana (PI)
  • Meydani, Simin (PI)
  • Palabrica, Theresa (PI)
  • King, Andrew (PI)
  • Boyd, Aubrey (PI)
  • Banks, Henry (PI)
  • Ryan, Richard (PI)
  • Wyler, David (PI)
  • Roth, David (PI)
  • Dawson-Hughes, Bess (PI)
  • Irons, Mira (PI)
  • Foss, Francine (PI)
  • Madoff, Morton (PI)
  • Schenkein, David (PI)
  • Morr, Jody (PI)
  • Harrington, John (PI)
  • Laut, Andrew (PI)
  • Kretschmar, Cynthia (PI)
  • Bellosillo, Nobel (PI)
  • Mahajan, Anita (PI)
  • Nunez, Evelyn (PI)
  • Castaneda, Carmen (PI)
  • Long, J. Scott (PI)
  • Schenkein, David (PI)
  • Morr, Jody (PI)
  • Mahajan, Anita (PI)
  • Sukiennik, Andrew (PI)
  • Nunez, Evelyn (PI)
  • Castaneda, Carmen (PI)
  • Foss, Francine (PI)
  • Frantz, Ivan (PI)
  • Harrington, John (PI)
  • Long, J. Scott (PI)
  • Castaneda, Carmen (PI)
  • Tanios, Maged (PI)
  • Timothy, Mcalindon (PI)
  • Sceppa, Carmen Castaneda (PI)
  • Madhumathi, Rao (PI)
  • Fiascone, John (PI)
  • Lieberman, Judith (PI)
  • Harris, Gordon (PI)
  • Roberge, Anne (PI)
  • Karp, Daniel (PI)
  • Grand, Richard (PI)
  • Elias, Ellen (PI)
  • Ball, Harrison (PI)
  • Haver, Kenan (PI)
  • [No Value], L.K. George (PI)
  • Weckstein, Douglas (PI)
  • Mason, Joel (PI)
  • Sukiennik, Andrew (PI)
  • Limentani, Steven (PI)
  • Trehu, Elizabeth (PI)
  • Madoc-Jones, Hywel (PI)
  • Levey, Andrew (PI)
  • Snydman, David (PI)
  • Dorkin, Henry (PI)
  • Munsat, Theodore (PI)
  • Atkins, Michael (PI)
  • Fawaz, Karim (PI)
  • Kaplan, Marshall (PI)
  • Goldin, Barry (PI)
  • Wolfe, Hubert (PI)
  • Roubenoff, Ronenn (PI)
  • Greenblatt, David J. (PI)
  • Skolnik, Paul (PI)
  • Schaefer, Ernst (PI)
  • Woods, Margo (PI)
  • Frantz, Ivan (PI)
  • Gorbach, Sherwood L. (PI)
  • Knox, Tasmin (PI)

Project: Research project

Description

The purpose of this research center is to provide facilities for the
conduct of clinical research at the Tufts-New England Medical Center
Hospital. The Unit serves the research requirements of the entire medical
center and is capable of providing a wide base of support for a variety of
clinical studies. The major studies now underway are: epidemiology and
biology of medullary thyroid carcinoma; mechanisms and therapy of endocrine
disorders including Cushing's disease, acromegaly, secondary amenorrhea,
sexual dysphoria, galactorrhea/amenorrhea/hyperprolactinemic syndromes,
diabetes mellitus and insipidus, multinodular goiter, and
panhypopituitarism; investigations in metabolic neuromuscular diseases
including tardive dyskinesia, Friedreich's ataxia, peroneal muscular
atrophy, amytrophic lateral sclerosis and the apinal muscular atrophies,
Parkinson's disease and other degenerative neurological conditions; therapy
of primary biliary cirrhosis with penicillamine and vitamin D.
Investigations of immune complex diseases; gonadotropin and growth hormone
short loop feedback; role of endorphins in growth hormone regulation;
ecology of debilitated E. Coli; mechanisms of diarrhea; glucose kinetics in
sepsis; studies of the serum amyloid protein; high dose cyclophosphamide
treatment of osteogenic and Ewing's sarcoma; study of hirsute and virilized
females; effect of choline and lecithin administration on memory function
in man; anti-hypertensive drugs and growth hormone secretion;prolactin
secretion in "euprolactinemic" galactorrhea with abnormal pituitary fossa
x-rays; luteinizing hormone-releasing hormone metabolism-role of the
n-terminal, hexapeptide as in index of LH-RH secretion; neuropsychiatric
aspects of pituitary prolactinomas; etiology of amyotrophic lateral
sclerosis; ulcerative colitis and cancer; precise localization of seizure
discharge foci utilizing chronic cortical EEG; acquired factor x deficiency
and systemic amyloidosis; effect of body habitus, age, nutritional status
on acetaminophen kinetics; temazepam kinetics in young and old humans;
pharmacokinetics of intravenous, intramuscular, oral, sublingual lorazepam;
clorazepam kinetics in young and elderly humans.
StatusFinished
Effective start/end date12/1/785/31/08

Funding

  • National Institutes of Health
  • National Institutes of Health

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Chronic Fatigue Syndrome
Leukocytes
Cytokines
Fatigue
Fever
Exercise
Myalgia

ASJC

  • Medicine(all)