NEUROMODULATOR INFLUENCES ON PREFRONTAL CORTICAL FUNCTION

Project: Research project

Description

DESCRIPTION (provided by applicant): A decline in cognitive functions such as attention, memory, and decision making is observed in a series of neurodegenerative conditions and mental illnesses. Cholinergic drugs (acetylcholine agonists and acetylcholinesterase inhibitors) can reverse these symptoms. Despite the known effectiveness of cholinergic drugs in improving cognitive function, the neuronal mechanisms of action in cortical areas involved in these processes, such as the prefrontal cortex are poorly understood. This project will investigate the effects of cholinergic drugs on prefrontal cortical activity during the execution of cognitive task and the effects of stimulation of the Nucleus Basalis, the main source of endogenous cortical acetylcholine. Neurophysiological recordings will be performed by a chronically implanted array of microelectrodes over the prefrontal cortex during the systemic administration of cholinergic agents and deep brain stimulation in a non- human primate model. The experiments will allow us to understand the effects of cholinergic agents in the prefrontal cortex associated with cognitive performance. They will also evaluate the relative effectiveness of drug administration compared to deep brain stimulation. Our research will also provide a primate model for the evaluation of new types of drugs that can potentially improve cognitive rehabilitation following injury or illness.
StatusFinished
Effective start/end date9/1/136/30/18

Funding

  • National Institutes of Health: $389,098.00
  • National Institutes of Health: $380,415.00
  • National Institutes of Health: $379,332.00

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Cholinergic Agents
Neurotransmitter Agents
Prefrontal Cortex
Deep Brain Stimulation
Cognition
Primates
Cholinergic Agonists
Drug Evaluation
Cholinesterase Inhibitors
Microelectrodes
Acetylcholine
Decision Making
Rehabilitation
Wounds and Injuries
Research
Pharmaceutical Preparations

ASJC

  • Medicine(all)