β2-adrenergic receptor gene and resting hemodynamics in European and African American youth

Harold Snieder, Yanbin Dong, Paule Barbeau, Gregory A Harshfield, Chrysoula Dalageogou, Haidong Zhu, Nicholas D. Carter, Frank A. Treiber

Research output: Contribution to journalArticle

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Abstract

Background: The β2-adrenergic receptor (ADRB2) contributes to blood pressure (BP) regulation by mediating peripheral vasodilation. Associations between the Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene and BP among multiethnic adult samples have been mixed. The purpose of this study was to investigate the relationship between these polymorphisms and resting hemodynamic function in African American (AA) and European American (EA) youths. Methods: We studied 395 EA and 275 AA twins from the southeastern United States (mean age, 14.6 ± 3.0 years; range, 10.0 to 25.9 years). The Arg16Gly and Gln27Glu polymorphisms were detected by polymerase chain reaction, followed by restriction enzyme digestion, and confirmed by direct sequence analysis. The effect of the polymorphisms on resting hemodynamics was analyzed using structural equation modeling. Results: For the Arg16Gly polymorphism, carriers of one or two Gly alleles exhibited significantly higher levels of systolic BP and pulse pressure in EA, respectively, explaining 2.6% and 2.8% of the variance. No significant associations were seen in AA. Carriers of the Glu allele of the Gln27Glu polymorphism showed an elevated systolic and diastolic BP, mean arterial pressure, total peripheral resistance index, and a lower stroke volume in EA. In AA, only diastolic BP showed a higher level in Glu carriers. Between 1.3% and 4.1% of the variance in these hemodynamic measures was explained by the Gln27Glu locus. Conclusions: The findings suggest that vasodilatory related genetic factors play a particularly important role in BP control in EA youths.

Original languageEnglish (US)
Pages (from-to)973-979
Number of pages7
JournalAmerican Journal of Hypertension
Volume15
Issue number11
DOIs
StatePublished - Nov 1 2002

Fingerprint

African Americans
Adrenergic Receptors
Hemodynamics
Blood Pressure
Genes
Alleles
Southeastern United States
Vasodilation
Vascular Resistance
Stroke Volume
Sequence Analysis
Digestion
Arterial Pressure
Polymerase Chain Reaction
Enzymes

Keywords

  • African American
  • Blood pressure variation
  • Hemodynamics
  • Polymorphism
  • β2-adrenergic receptor gene

ASJC Scopus subject areas

  • Internal Medicine

Cite this

β2-adrenergic receptor gene and resting hemodynamics in European and African American youth. / Snieder, Harold; Dong, Yanbin; Barbeau, Paule; Harshfield, Gregory A; Dalageogou, Chrysoula; Zhu, Haidong; Carter, Nicholas D.; Treiber, Frank A.

In: American Journal of Hypertension, Vol. 15, No. 11, 01.11.2002, p. 973-979.

Research output: Contribution to journalArticle

Snieder, Harold ; Dong, Yanbin ; Barbeau, Paule ; Harshfield, Gregory A ; Dalageogou, Chrysoula ; Zhu, Haidong ; Carter, Nicholas D. ; Treiber, Frank A. / β2-adrenergic receptor gene and resting hemodynamics in European and African American youth. In: American Journal of Hypertension. 2002 ; Vol. 15, No. 11. pp. 973-979.
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abstract = "Background: The β2-adrenergic receptor (ADRB2) contributes to blood pressure (BP) regulation by mediating peripheral vasodilation. Associations between the Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene and BP among multiethnic adult samples have been mixed. The purpose of this study was to investigate the relationship between these polymorphisms and resting hemodynamic function in African American (AA) and European American (EA) youths. Methods: We studied 395 EA and 275 AA twins from the southeastern United States (mean age, 14.6 ± 3.0 years; range, 10.0 to 25.9 years). The Arg16Gly and Gln27Glu polymorphisms were detected by polymerase chain reaction, followed by restriction enzyme digestion, and confirmed by direct sequence analysis. The effect of the polymorphisms on resting hemodynamics was analyzed using structural equation modeling. Results: For the Arg16Gly polymorphism, carriers of one or two Gly alleles exhibited significantly higher levels of systolic BP and pulse pressure in EA, respectively, explaining 2.6{\%} and 2.8{\%} of the variance. No significant associations were seen in AA. Carriers of the Glu allele of the Gln27Glu polymorphism showed an elevated systolic and diastolic BP, mean arterial pressure, total peripheral resistance index, and a lower stroke volume in EA. In AA, only diastolic BP showed a higher level in Glu carriers. Between 1.3{\%} and 4.1{\%} of the variance in these hemodynamic measures was explained by the Gln27Glu locus. Conclusions: The findings suggest that vasodilatory related genetic factors play a particularly important role in BP control in EA youths.",
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AU - Dalageogou, Chrysoula

AU - Zhu, Haidong

AU - Carter, Nicholas D.

AU - Treiber, Frank A.

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