γ chain abnormalities and γglobin gene rearrangements in newborn babies of various populations

T. H.J. Huisman, Ferdane Kutlar, L. H. Gu

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

The present review provides a summary of quantitative hemoglobin data and lists the results of gene mapping and sequencing analyses for blood samples from newborn babies of different countries. Methodology suitable for such studies is reviewed, various abnormal fetal hemoglobins are discussed, the occurrence of Hb Bart's (γ4) and of the embryonic chain is evaluated, and the various types of γglobin gene rearrangements (-Aγ. Aγ; -Gγ. Gγ; γthalassemia; γglobin gene triplications, quadruplications, and quintuplications) are compared. The several tables list the frequencies of the common AγT variant and of the different γ gene rearrangements in various populations, while the results of quantitative analyses suggest that most anomalies are not associated with disease.

Original languageEnglish (US)
Pages (from-to)349-379
Number of pages31
JournalHemoglobin
Volume15
Issue number5
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Genetics(clinical)
  • Biochemistry, medical

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