Δ5-Androstene-3β,17β-diol in healthy eumenorrheic women: Relationship to body mass and hormonal profile

Ricardo Azziz, H. D. Potter, E. L. Bradley, L. R. Boots

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective: To determine whether Δ5-Androstene-3β,17β-diol or androstenediol secretion increases with body mass. Design: A prospective study. Setting: University-based clinical research center. Patients: Twenty healthy, nonhirsute, eumenorrheic women, 10 with a body mass index (BMI) 31 kg/m2 and 10 with a BMI > 31 kg/m2 were studied. Interventions: All patients had blood sampled before (0 minute) and 60 minute after acute administration of 1 mg ACTH-(1-24) IV. Body circumferences were obtained, and the BMI and waist-hip ratio was calculated. Main Outcome Measures: Total T, androstenedione (A), E2, sex hormone binding globulin, DHEA, DHEAS, and androstenediol were measured at 0 minutes (steroid0); and DHEA, A and androstenediol were also measured after stimulation (steroid60). The net steroid increment (Δ) from 0 to 60 minute was calculated. Results: Compared with thin women, obese subjects had higher levels of androstenediol60 (95.8 ± 20.3 versus 130.7 ± 40.7 ng/dL, respectively [conversion factor to SI units, 0.03443]) and Δandrostenediol (17.4 ± 8.7 versus 37.8 ± 29.0 ng/dL, respectively [conversion factor to SI units, 0.03443]). Neither the BMI, height, nor the body circumference measures correlated with any of the steroid levels or responses to adrenal stimulation, except for a weak positive correlation between BMI and estrone (E1) (r = 0.38) and a negative correlation between waist-hip ratio and Δandrostenediol (r = -0.51). The basal level of T, E1, and DHEA0, but not A or DHEAS, correlated with androstenediol0 (r = 0.65, 0.62, and 0.67, respectively) and Δandrostenediol (r = 0.66, 0.63, and 0.63 to 0.005, respectively). Conclusions: Although the unstimulated morning androstenediol level did not differ between obese and thin euandrogenic healthy women, the response of androstenediol to ACTH-(1-24) stimulation was greater in obese individuals. The present findings, together with our previous data demonstrating an increased adrenal secretion of the E1 precursor A in response to ACTH in obese women, suggests that the adrenal cortex in overweight women may further enhance the estrogenic milieu of these women.

Original languageEnglish (US)
Pages (from-to)321-326
Number of pages6
JournalFertility and sterility
Volume62
Issue number2
StatePublished - Jan 1 1994

Fingerprint

Androstenediol
Body Mass Index
International System of Units
Cosyntropin
Waist-Hip Ratio
Dehydroepiandrosterone
Steroids
Body Weights and Measures
Sex Hormone-Binding Globulin
Androstenedione
Estrone
Adrenal Cortex
Adrenocorticotropic Hormone
Outcome Assessment (Health Care)
Prospective Studies

Keywords

  • Androstenediol
  • adrenal
  • adrenal androgens
  • obesity

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Δ5-Androstene-3β,17β-diol in healthy eumenorrheic women : Relationship to body mass and hormonal profile. / Azziz, Ricardo; Potter, H. D.; Bradley, E. L.; Boots, L. R.

In: Fertility and sterility, Vol. 62, No. 2, 01.01.1994, p. 321-326.

Research output: Contribution to journalArticle

Azziz, R, Potter, HD, Bradley, EL & Boots, LR 1994, 'Δ5-Androstene-3β,17β-diol in healthy eumenorrheic women: Relationship to body mass and hormonal profile', Fertility and sterility, vol. 62, no. 2, pp. 321-326.
Azziz, Ricardo ; Potter, H. D. ; Bradley, E. L. ; Boots, L. R. / Δ5-Androstene-3β,17β-diol in healthy eumenorrheic women : Relationship to body mass and hormonal profile. In: Fertility and sterility. 1994 ; Vol. 62, No. 2. pp. 321-326.
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title = "Δ5-Androstene-3β,17β-diol in healthy eumenorrheic women: Relationship to body mass and hormonal profile",
abstract = "Objective: To determine whether Δ5-Androstene-3β,17β-diol or androstenediol secretion increases with body mass. Design: A prospective study. Setting: University-based clinical research center. Patients: Twenty healthy, nonhirsute, eumenorrheic women, 10 with a body mass index (BMI) 31 kg/m2 and 10 with a BMI > 31 kg/m2 were studied. Interventions: All patients had blood sampled before (0 minute) and 60 minute after acute administration of 1 mg ACTH-(1-24) IV. Body circumferences were obtained, and the BMI and waist-hip ratio was calculated. Main Outcome Measures: Total T, androstenedione (A), E2, sex hormone binding globulin, DHEA, DHEAS, and androstenediol were measured at 0 minutes (steroid0); and DHEA, A and androstenediol were also measured after stimulation (steroid60). The net steroid increment (Δ) from 0 to 60 minute was calculated. Results: Compared with thin women, obese subjects had higher levels of androstenediol60 (95.8 ± 20.3 versus 130.7 ± 40.7 ng/dL, respectively [conversion factor to SI units, 0.03443]) and Δandrostenediol (17.4 ± 8.7 versus 37.8 ± 29.0 ng/dL, respectively [conversion factor to SI units, 0.03443]). Neither the BMI, height, nor the body circumference measures correlated with any of the steroid levels or responses to adrenal stimulation, except for a weak positive correlation between BMI and estrone (E1) (r = 0.38) and a negative correlation between waist-hip ratio and Δandrostenediol (r = -0.51). The basal level of T, E1, and DHEA0, but not A or DHEAS, correlated with androstenediol0 (r = 0.65, 0.62, and 0.67, respectively) and Δandrostenediol (r = 0.66, 0.63, and 0.63 to 0.005, respectively). Conclusions: Although the unstimulated morning androstenediol level did not differ between obese and thin euandrogenic healthy women, the response of androstenediol to ACTH-(1-24) stimulation was greater in obese individuals. The present findings, together with our previous data demonstrating an increased adrenal secretion of the E1 precursor A in response to ACTH in obese women, suggests that the adrenal cortex in overweight women may further enhance the estrogenic milieu of these women.",
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T1 - Δ5-Androstene-3β,17β-diol in healthy eumenorrheic women

T2 - Relationship to body mass and hormonal profile

AU - Azziz, Ricardo

AU - Potter, H. D.

AU - Bradley, E. L.

AU - Boots, L. R.

PY - 1994/1/1

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N2 - Objective: To determine whether Δ5-Androstene-3β,17β-diol or androstenediol secretion increases with body mass. Design: A prospective study. Setting: University-based clinical research center. Patients: Twenty healthy, nonhirsute, eumenorrheic women, 10 with a body mass index (BMI) 31 kg/m2 and 10 with a BMI > 31 kg/m2 were studied. Interventions: All patients had blood sampled before (0 minute) and 60 minute after acute administration of 1 mg ACTH-(1-24) IV. Body circumferences were obtained, and the BMI and waist-hip ratio was calculated. Main Outcome Measures: Total T, androstenedione (A), E2, sex hormone binding globulin, DHEA, DHEAS, and androstenediol were measured at 0 minutes (steroid0); and DHEA, A and androstenediol were also measured after stimulation (steroid60). The net steroid increment (Δ) from 0 to 60 minute was calculated. Results: Compared with thin women, obese subjects had higher levels of androstenediol60 (95.8 ± 20.3 versus 130.7 ± 40.7 ng/dL, respectively [conversion factor to SI units, 0.03443]) and Δandrostenediol (17.4 ± 8.7 versus 37.8 ± 29.0 ng/dL, respectively [conversion factor to SI units, 0.03443]). Neither the BMI, height, nor the body circumference measures correlated with any of the steroid levels or responses to adrenal stimulation, except for a weak positive correlation between BMI and estrone (E1) (r = 0.38) and a negative correlation between waist-hip ratio and Δandrostenediol (r = -0.51). The basal level of T, E1, and DHEA0, but not A or DHEAS, correlated with androstenediol0 (r = 0.65, 0.62, and 0.67, respectively) and Δandrostenediol (r = 0.66, 0.63, and 0.63 to 0.005, respectively). Conclusions: Although the unstimulated morning androstenediol level did not differ between obese and thin euandrogenic healthy women, the response of androstenediol to ACTH-(1-24) stimulation was greater in obese individuals. The present findings, together with our previous data demonstrating an increased adrenal secretion of the E1 precursor A in response to ACTH in obese women, suggests that the adrenal cortex in overweight women may further enhance the estrogenic milieu of these women.

AB - Objective: To determine whether Δ5-Androstene-3β,17β-diol or androstenediol secretion increases with body mass. Design: A prospective study. Setting: University-based clinical research center. Patients: Twenty healthy, nonhirsute, eumenorrheic women, 10 with a body mass index (BMI) 31 kg/m2 and 10 with a BMI > 31 kg/m2 were studied. Interventions: All patients had blood sampled before (0 minute) and 60 minute after acute administration of 1 mg ACTH-(1-24) IV. Body circumferences were obtained, and the BMI and waist-hip ratio was calculated. Main Outcome Measures: Total T, androstenedione (A), E2, sex hormone binding globulin, DHEA, DHEAS, and androstenediol were measured at 0 minutes (steroid0); and DHEA, A and androstenediol were also measured after stimulation (steroid60). The net steroid increment (Δ) from 0 to 60 minute was calculated. Results: Compared with thin women, obese subjects had higher levels of androstenediol60 (95.8 ± 20.3 versus 130.7 ± 40.7 ng/dL, respectively [conversion factor to SI units, 0.03443]) and Δandrostenediol (17.4 ± 8.7 versus 37.8 ± 29.0 ng/dL, respectively [conversion factor to SI units, 0.03443]). Neither the BMI, height, nor the body circumference measures correlated with any of the steroid levels or responses to adrenal stimulation, except for a weak positive correlation between BMI and estrone (E1) (r = 0.38) and a negative correlation between waist-hip ratio and Δandrostenediol (r = -0.51). The basal level of T, E1, and DHEA0, but not A or DHEAS, correlated with androstenediol0 (r = 0.65, 0.62, and 0.67, respectively) and Δandrostenediol (r = 0.66, 0.63, and 0.63 to 0.005, respectively). Conclusions: Although the unstimulated morning androstenediol level did not differ between obese and thin euandrogenic healthy women, the response of androstenediol to ACTH-(1-24) stimulation was greater in obese individuals. The present findings, together with our previous data demonstrating an increased adrenal secretion of the E1 precursor A in response to ACTH in obese women, suggests that the adrenal cortex in overweight women may further enhance the estrogenic milieu of these women.

KW - Androstenediol

KW - adrenal

KW - adrenal androgens

KW - obesity

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