1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women

Chandrasekhar Thota, Ramkumar Menon, Stephen J. Fortunato, Lina Brou, Jae Eun Lee, Ayman Al-Hendy

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.

Original languageEnglish (US)
Pages (from-to)244-250
Number of pages7
JournalReproductive Sciences
Volume21
Issue number2
DOIs
StatePublished - Jan 1 2014

Fingerprint

Premature Birth
African Americans
Vitamin D
Ergocalciferols
Serum
Avitaminosis
Vitamin D Deficiency
Luminescence
Radioimmunoassay
1,25-dihydroxyvitamin D
Pregnant Women
Inflammation
Pregnancy

Keywords

  • 1,25-(OH)2 vitamin D
  • 25-(OH) vitamin D
  • African Americans
  • Caucasians
  • preterm birth
  • serum levels

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. / Thota, Chandrasekhar; Menon, Ramkumar; Fortunato, Stephen J.; Brou, Lina; Lee, Jae Eun; Al-Hendy, Ayman.

In: Reproductive Sciences, Vol. 21, No. 2, 01.01.2014, p. 244-250.

Research output: Contribution to journalArticle

Thota, Chandrasekhar ; Menon, Ramkumar ; Fortunato, Stephen J. ; Brou, Lina ; Lee, Jae Eun ; Al-Hendy, Ayman. / 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women. In: Reproductive Sciences. 2014 ; Vol. 21, No. 2. pp. 244-250.
@article{bbeaab7b82e74c73a10f7d4a21c83e97,
title = "1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women",
abstract = "Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.",
keywords = "1,25-(OH)2 vitamin D, 25-(OH) vitamin D, African Americans, Caucasians, preterm birth, serum levels",
author = "Chandrasekhar Thota and Ramkumar Menon and Fortunato, {Stephen J.} and Lina Brou and Lee, {Jae Eun} and Ayman Al-Hendy",
year = "2014",
month = "1",
day = "1",
doi = "10.1177/1933719113493513",
language = "English (US)",
volume = "21",
pages = "244--250",
journal = "Reproductive Sciences",
issn = "1933-7191",
publisher = "SAGE Publications Inc.",
number = "2",

}

TY - JOUR

T1 - 1,25-Dihydroxyvitamin D deficiency is associated with preterm birth in African American and Caucasian women

AU - Thota, Chandrasekhar

AU - Menon, Ramkumar

AU - Fortunato, Stephen J.

AU - Brou, Lina

AU - Lee, Jae Eun

AU - Al-Hendy, Ayman

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.

AB - Vitamin (vit) D deficiency and preterm birth (PTB) are more prevalent among African American (AA) women compared to caucasian (Cau) women. Because vit D is important in regulating cell-mediated immune responses, vit D insufficiency or deficiency during pregnancy may enhance inflammation in pregnant women and increase the risk of PTB. In this study, circulatory levels of 25-hydroxy (OH) and 1,25-dihydroxy (OH)2 vit D were measured using chemiluminescence and radioimmunoassay techniques, respectively, in AA (n = 108) and Cau (n = 84) women who delivered at term and preterm. The results from this study suggest that the serum levels of the 25-(OH) vit D concentrations tend to decrease (P =.06) in the Cau women who delivered at preterm compared to those delivering at term. However, the 25-(OH) vit D levels in Cau and AA between term and preterm deliveries were not significantly different. The serum levels of 1,25-(OH)2 vit D were found to be significantly lower in AA women compared to Cau women (P <.02) at term, and in the Cau (P <.01) and AA (P <.04) women delivering at preterm compared to those delivering at term. One-way analysis of variance demonstrated that 1,25-(OH)2 vit D levels were significantly lower in participants delivering at preterm (<34 weeks and between 34 and 37 weeks) compared to those delivering at term (>37 weeks).These results suggest that low levels of serum 1,25-(OH)2 vit D are associated with PTB, and vit D can potentially be used as a novel diagnostic marker in the detection of PTB.

KW - 1,25-(OH)2 vitamin D

KW - 25-(OH) vitamin D

KW - African Americans

KW - Caucasians

KW - preterm birth

KW - serum levels

UR - http://www.scopus.com/inward/record.url?scp=84901777685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901777685&partnerID=8YFLogxK

U2 - 10.1177/1933719113493513

DO - 10.1177/1933719113493513

M3 - Article

VL - 21

SP - 244

EP - 250

JO - Reproductive Sciences

JF - Reproductive Sciences

SN - 1933-7191

IS - 2

ER -