25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation

Laura D Carbone, E. William Rosenberg, Elizabeth A. Tolley, Michael F. Holick, Thomas A. Hughes, Mitchell Aaron Watsky, Karen D. Barrow, Tai C. Chen, Nathaniel K. Wilkin, Syamal K. Bhattacharya, John C. Dowdy, Robert M. Sayre, Karl T. Weber

Research output: Contribution to journalArticle

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Abstract

Vitamin D deficiency may have implications for cardiovascular health. The purpose of this study was to determine the relationship of 25-hydroxyvitamin D (25[OH]D) to cholesterol and lipoprotein particles and to determine whether increasing 25(OH)D through ultraviolet (UV) irradiation impacted on these parameters in healthy young men and women. This was a randomized trial of 51 adults exposed to suberythemal doses of whole-body irradiation using UV lamps that emitted UV-A and UV-B radiation, compared with a control group, twice weekly for 12 weeks. 25-Hydroxyvitamin D, cholesterol, and lipoprotein subfractions were measured at baseline and after 12 weeks. There was a significant (P < .03) positive association between 25(OH)D and apolipoprotein A-I (Apo A-I) and lipoprotein A-I (Lp A-I). The ratio of low-density lipoprotein to high-density lipoprotein was significantly (P ≤ .044) negatively correlated with 25(OH)D levels. The levels of 25(OH)D increased significantly in the treated compared with control group (P < .05). Overall, there were no significant differences between the treated and control groups in any lipoproteins or apolipoproteins after administration of UV irradiation. Subgroup analysis for Apo A-II confined to those with 25(OH)D insufficiency (25[OH]D <75 nmol/L [30 ng/mL]) revealed decreases in Apo A-II in the treated group and increases in the control group that were statistically significantly different between the groups (P = .026). We found a significant positive correlation between 25(OH)D and Apo A-I and Lp A-I and a significant negative correlation between 25(OH)D and the ratio of low-density lipoprotein to high-density lipoprotein. In those with vitamin D insufficiency, we found small decreases in Apo A-II in the treated relative to the control group. Overall, though, twice weekly exposure to UV radiation resulting in an increase in serum 25(OH)D had no significant impact on lipoprotein composition.

Original languageEnglish (US)
Pages (from-to)741-748
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume57
Issue number6
DOIs
StatePublished - Jun 1 2008

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Apolipoprotein A-II
Cholesterol
Control Groups
Apolipoprotein A-I
HDL Lipoproteins
LDL Lipoproteins
Lipoproteins
Radiation
Vitamin D Deficiency
Apolipoproteins
Whole-Body Irradiation
Vitamin D
25-hydroxyvitamin D
Health
Serum
lipoprotein A-I
lipoprotein cholesterol

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. / Carbone, Laura D; Rosenberg, E. William; Tolley, Elizabeth A.; Holick, Michael F.; Hughes, Thomas A.; Watsky, Mitchell Aaron; Barrow, Karen D.; Chen, Tai C.; Wilkin, Nathaniel K.; Bhattacharya, Syamal K.; Dowdy, John C.; Sayre, Robert M.; Weber, Karl T.

In: Metabolism: Clinical and Experimental, Vol. 57, No. 6, 01.06.2008, p. 741-748.

Research output: Contribution to journalArticle

Carbone, LD, Rosenberg, EW, Tolley, EA, Holick, MF, Hughes, TA, Watsky, MA, Barrow, KD, Chen, TC, Wilkin, NK, Bhattacharya, SK, Dowdy, JC, Sayre, RM & Weber, KT 2008, '25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation', Metabolism: Clinical and Experimental, vol. 57, no. 6, pp. 741-748. https://doi.org/10.1016/j.metabol.2008.01.011
Carbone, Laura D ; Rosenberg, E. William ; Tolley, Elizabeth A. ; Holick, Michael F. ; Hughes, Thomas A. ; Watsky, Mitchell Aaron ; Barrow, Karen D. ; Chen, Tai C. ; Wilkin, Nathaniel K. ; Bhattacharya, Syamal K. ; Dowdy, John C. ; Sayre, Robert M. ; Weber, Karl T. / 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. In: Metabolism: Clinical and Experimental. 2008 ; Vol. 57, No. 6. pp. 741-748.
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