25-Hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth

M. E. Breen, E. M. Laing, D. B. Hall, D. B. Hausman, R. G. Taylor, Carlos M Isales, Kehong Ding, Norman K. Pollock, Mark W Hamrick, C. A. Baile, R. D. Lewis

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear. Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal females (n = 76; aged 4-8 yr at baseline) over a period of up to 9 yr. Design: The hypothesis that changes in IGF-I vs. 25(OH)D are more strongly associated with BMC accrual was formulated after data collection. 25(OH)D and IGF-I were log-transformed and further adjusted using two-way ANOVA for differences in season and race. Linear mixed modeling (including a random subject-specific intercept and a random subject-specific slope on age) was employed to analyze the proportion of variance the transformed 25(OH)D and IGF-I variables explained for the bone outcomes. Results: IGF-I was more strongly associated with BMC accrual than 25(OH)D at the total body (R2 = 0.874 vs. 0.809), proximal femur (R2 = 0.847 vs. 0.771), radius (R2 = 0.812 vs. 0.759), and lumbar spine (R2=0.759 vs. 0.698). The rate of BMC accrual was positively associated with changesin IGF-I but negatively associated with 25(OH)D. When IGF-I and 25(OH)D were included in the same regression equation, 25(OH)D did not have a significant predictive effect on BMC accrual above and beyond that of IGF-I. Conclusions: These prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-I and BMC accrual is greater than the negative association of 25(OH)D and BMC accrual.

Original languageEnglish (US)
JournalJournal of Clinical Endocrinology and Metabolism
Volume96
Issue number1
DOIs
StatePublished - Jan 1 2011

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Insulin-Like Growth Factor I
Minerals
Bone
Bone Density
Bone and Bones
Growth
Analysis of Variance
25-hydroxyvitamin D
Independent Living
Puberty
Analysis of variance (ANOVA)
Femur
Spine

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

25-Hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth. / Breen, M. E.; Laing, E. M.; Hall, D. B.; Hausman, D. B.; Taylor, R. G.; Isales, Carlos M; Ding, Kehong; Pollock, Norman K.; Hamrick, Mark W; Baile, C. A.; Lewis, R. D.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 96, No. 1, 01.01.2011.

Research output: Contribution to journalArticle

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AU - Breen, M. E.

AU - Laing, E. M.

AU - Hall, D. B.

AU - Hausman, D. B.

AU - Taylor, R. G.

AU - Isales, Carlos M

AU - Ding, Kehong

AU - Pollock, Norman K.

AU - Hamrick, Mark W

AU - Baile, C. A.

AU - Lewis, R. D.

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AB - Context: The extent to which 25-hydroxyvitamin D [25(OH)D] and IGF-I influence bone mineral content (BMC) accrual from early to mid-puberty is unclear. Objective, Setting, and Participants: This study sought to determine relationships among 25(OH)D, IGF-I, and BMC in community-dwelling prepubertal females (n = 76; aged 4-8 yr at baseline) over a period of up to 9 yr. Design: The hypothesis that changes in IGF-I vs. 25(OH)D are more strongly associated with BMC accrual was formulated after data collection. 25(OH)D and IGF-I were log-transformed and further adjusted using two-way ANOVA for differences in season and race. Linear mixed modeling (including a random subject-specific intercept and a random subject-specific slope on age) was employed to analyze the proportion of variance the transformed 25(OH)D and IGF-I variables explained for the bone outcomes. Results: IGF-I was more strongly associated with BMC accrual than 25(OH)D at the total body (R2 = 0.874 vs. 0.809), proximal femur (R2 = 0.847 vs. 0.771), radius (R2 = 0.812 vs. 0.759), and lumbar spine (R2=0.759 vs. 0.698). The rate of BMC accrual was positively associated with changesin IGF-I but negatively associated with 25(OH)D. When IGF-I and 25(OH)D were included in the same regression equation, 25(OH)D did not have a significant predictive effect on BMC accrual above and beyond that of IGF-I. Conclusions: These prospective data in early adolescent females indicate that both 25(OH)D and IGF-I have a significant impact on bone mineral accrual; however, the positive association of IGF-I and BMC accrual is greater than the negative association of 25(OH)D and BMC accrual.

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