A 66-year-old woman with a rapidly progressing dementia and basal ganglia involvement

Michael Gold, Amyn Rojiani, Reed Murtaugh

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A 66-year-old woman presented with a rapidly progressive dementia initially characterized by an auditory agnosia. She experienced a rapid progression of her aphasia and developed ataxia and myoclonus. An initial neurological evaluation suggested a left parieto-temporal lesion, however, neuroimaging did not reveal any. An MRI of her brain demonstrated highly focal T2 hyperintensities in her basal ganglia. The patient was diagnosed with Creutzfeldt-Jacob disease (CJD) on the basis of the presence of two proteins in the CSF that are highly sensitive and specific for CJD. Pathological examination confirmed the diagnosis. The differential diagnosis and utility of MRI in patients with CJD is discussed.

Original languageEnglish (US)
Pages (from-to)171-175
Number of pages5
JournalJournal of Neuroimaging
Volume7
Issue number3
DOIs
StatePublished - Jul 1997
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

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