A biochemical function for attractin in agouti-induced pigmentation and obesity

Lin He, Teresa M. Gunn, Donna M. Bouley, Xinyun Lu, Stanley J. Watson, Stuart F. Schlossman, Jonathan S. Duke-Cohan, Gregory S. Barsh

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (Aγ) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the hypothalamus. Mouse attractin (Atrn) is a widely expressed transmembrane protein whose loss of function in mahogany (Atrnmg-3J/Atrnmg-3J) mutant mice blocks the pleiotropic effects of Aγ. Here we demonstrate in transgenic, biochemical and genetic-interaction experiments that attractin is a low-affinity receptor for agouti protein, but not Agrp, in vitro and in vivo. Additional histopathologic abnormalities in Atrnmg-3J/Atrnmg-3J mice and cross-species genomic comparisons indicate that Atrn has multiple functions distinct from both a physiologic and an evolutionary perspective.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalNature Genetics
Volume27
Issue number1
DOIs
StatePublished - Jan 20 2001

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Pigmentation
Agouti Signaling Protein
Agouti-Related Protein
Obesity
Paracrine Communication
Hypothalamus
Molecular Biology
Skin
Dasyproctidae
Proteins

ASJC Scopus subject areas

  • Genetics

Cite this

He, L., Gunn, T. M., Bouley, D. M., Lu, X., Watson, S. J., Schlossman, S. F., ... Barsh, G. S. (2001). A biochemical function for attractin in agouti-induced pigmentation and obesity. Nature Genetics, 27(1), 40-47. https://doi.org/10.1038/83741

A biochemical function for attractin in agouti-induced pigmentation and obesity. / He, Lin; Gunn, Teresa M.; Bouley, Donna M.; Lu, Xinyun; Watson, Stanley J.; Schlossman, Stuart F.; Duke-Cohan, Jonathan S.; Barsh, Gregory S.

In: Nature Genetics, Vol. 27, No. 1, 20.01.2001, p. 40-47.

Research output: Contribution to journalArticle

He, L, Gunn, TM, Bouley, DM, Lu, X, Watson, SJ, Schlossman, SF, Duke-Cohan, JS & Barsh, GS 2001, 'A biochemical function for attractin in agouti-induced pigmentation and obesity', Nature Genetics, vol. 27, no. 1, pp. 40-47. https://doi.org/10.1038/83741
He L, Gunn TM, Bouley DM, Lu X, Watson SJ, Schlossman SF et al. A biochemical function for attractin in agouti-induced pigmentation and obesity. Nature Genetics. 2001 Jan 20;27(1):40-47. https://doi.org/10.1038/83741
He, Lin ; Gunn, Teresa M. ; Bouley, Donna M. ; Lu, Xinyun ; Watson, Stanley J. ; Schlossman, Stuart F. ; Duke-Cohan, Jonathan S. ; Barsh, Gregory S. / A biochemical function for attractin in agouti-induced pigmentation and obesity. In: Nature Genetics. 2001 ; Vol. 27, No. 1. pp. 40-47.
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