Abstract
Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (Aγ) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the hypothalamus. Mouse attractin (Atrn) is a widely expressed transmembrane protein whose loss of function in mahogany (Atrnmg-3J/Atrnmg-3J) mutant mice blocks the pleiotropic effects of Aγ. Here we demonstrate in transgenic, biochemical and genetic-interaction experiments that attractin is a low-affinity receptor for agouti protein, but not Agrp, in vitro and in vivo. Additional histopathologic abnormalities in Atrnmg-3J/Atrnmg-3J mice and cross-species genomic comparisons indicate that Atrn has multiple functions distinct from both a physiologic and an evolutionary perspective.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 40-47 |
| Number of pages | 8 |
| Journal | Nature Genetics |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 20 2001 |
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ASJC Scopus subject areas
- Genetics
Cite this
A biochemical function for attractin in agouti-induced pigmentation and obesity. / He, Lin; Gunn, Teresa M.; Bouley, Donna M.; Lu, Xinyun; Watson, Stanley J.; Schlossman, Stuart F.; Duke-Cohan, Jonathan S.; Barsh, Gregory S.
In: Nature Genetics, Vol. 27, No. 1, 20.01.2001, p. 40-47.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A biochemical function for attractin in agouti-induced pigmentation and obesity
AU - He, Lin
AU - Gunn, Teresa M.
AU - Bouley, Donna M.
AU - Lu, Xinyun
AU - Watson, Stanley J.
AU - Schlossman, Stuart F.
AU - Duke-Cohan, Jonathan S.
AU - Barsh, Gregory S.
PY - 2001/1/20
Y1 - 2001/1/20
N2 - Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (Aγ) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the hypothalamus. Mouse attractin (Atrn) is a widely expressed transmembrane protein whose loss of function in mahogany (Atrnmg-3J/Atrnmg-3J) mutant mice blocks the pleiotropic effects of Aγ. Here we demonstrate in transgenic, biochemical and genetic-interaction experiments that attractin is a low-affinity receptor for agouti protein, but not Agrp, in vitro and in vivo. Additional histopathologic abnormalities in Atrnmg-3J/Atrnmg-3J mice and cross-species genomic comparisons indicate that Atrn has multiple functions distinct from both a physiologic and an evolutionary perspective.
AB - Agouti protein, a paracrine signaling molecule normally limited to skin, is ectopically expressed in lethal yellow (Aγ) mice, and causes obesity by mimicking agouti-related protein (Agrp), found primarily in the hypothalamus. Mouse attractin (Atrn) is a widely expressed transmembrane protein whose loss of function in mahogany (Atrnmg-3J/Atrnmg-3J) mutant mice blocks the pleiotropic effects of Aγ. Here we demonstrate in transgenic, biochemical and genetic-interaction experiments that attractin is a low-affinity receptor for agouti protein, but not Agrp, in vitro and in vivo. Additional histopathologic abnormalities in Atrnmg-3J/Atrnmg-3J mice and cross-species genomic comparisons indicate that Atrn has multiple functions distinct from both a physiologic and an evolutionary perspective.
UR - http://www.scopus.com/inward/record.url?scp=0035167085&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035167085&partnerID=8YFLogxK
U2 - 10.1038/83741
DO - 10.1038/83741
M3 - Article
C2 - 11137996
AN - SCOPUS:0035167085
VL - 27
SP - 40
EP - 47
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 1
ER -