TY - JOUR
T1 - A case report of orbital inflammatory syndrome secondary to ipilimumab
AU - Henderson, Amanda D.
AU - Thomas, Dilip A.
N1 - Publisher Copyright:
© Copyright 2014 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.
PY - 2015
Y1 - 2015
N2 - Ipilimumab is a monoclonal antibody to cytotoxic T-lymphocyte antigen-4, a negative regulator of T-cell-mediated immune response. Ipilimumab is approved by the US Food and Drug Administration for the treatment of advanced melanoma. However, its use frequently has been associated with immune-related side effects, which can be explained by its mechanism of action. More common adverse effects include dermatitis, colitis, hepatitis, and endocrinopathies, but many less common immune-related adverse effects that involve various tissues and organ systems have been reported with more widespread use of ipilimumab since its approval in 2011. A case of bilateral orbital inflammatory syndrome secondary to ipilimumab, in a patient undergoing adjuvant treatment for metastatic melanoma, is reported.
AB - Ipilimumab is a monoclonal antibody to cytotoxic T-lymphocyte antigen-4, a negative regulator of T-cell-mediated immune response. Ipilimumab is approved by the US Food and Drug Administration for the treatment of advanced melanoma. However, its use frequently has been associated with immune-related side effects, which can be explained by its mechanism of action. More common adverse effects include dermatitis, colitis, hepatitis, and endocrinopathies, but many less common immune-related adverse effects that involve various tissues and organ systems have been reported with more widespread use of ipilimumab since its approval in 2011. A case of bilateral orbital inflammatory syndrome secondary to ipilimumab, in a patient undergoing adjuvant treatment for metastatic melanoma, is reported.
UR - http://www.scopus.com/inward/record.url?scp=84899782496&partnerID=8YFLogxK
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U2 - 10.1097/IOP.0000000000000081
DO - 10.1097/IOP.0000000000000081
M3 - Article
C2 - 24814274
AN - SCOPUS:84899782496
SN - 0740-9303
VL - 31
SP - e68-e70
JO - Ophthalmic Plastic and Reconstructive Surgery
JF - Ophthalmic Plastic and Reconstructive Surgery
IS - 3
ER -