A chromosome with five γ-globin genes

Y. J. Fei, D. Lanclos Ke., F. Kutlar, E. F. Walker, T. H.J. Huisman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Globin gene mapping of DNA from a Black newborn resulted in the detection of a chromosome with five γ-globin genes. Based on results from digests with enzymes EcoRI and PstI, we concluded that the three genes between the 5'(G)γ and 3'(A)γ genes are (G)γ genes with a possible 5' segment derived from (A)γ. The high (G)γ level in the fetal hemoglobin (Hb F) of the baby is consistent with this view. Family relationships were such that speculation as to the mechanism causing this quintuplication of the γ-globin genes was not possible.

Original languageEnglish (US)
Pages (from-to)827-829
Number of pages3
JournalBlood
Volume72
Issue number2
StatePublished - Jan 1 1988

Fingerprint

Globins
Chromosomes
Genes
Fetal Hemoglobin
Chromosome Mapping
Newborn Infant
DNA
Enzymes

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Fei, Y. J., Lanclos Ke., D., Kutlar, F., Walker, E. F., & Huisman, T. H. J. (1988). A chromosome with five γ-globin genes. Blood, 72(2), 827-829.

A chromosome with five γ-globin genes. / Fei, Y. J.; Lanclos Ke., D.; Kutlar, F.; Walker, E. F.; Huisman, T. H.J.

In: Blood, Vol. 72, No. 2, 01.01.1988, p. 827-829.

Research output: Contribution to journalArticle

Fei, YJ, Lanclos Ke., D, Kutlar, F, Walker, EF & Huisman, THJ 1988, 'A chromosome with five γ-globin genes', Blood, vol. 72, no. 2, pp. 827-829.
Fei YJ, Lanclos Ke. D, Kutlar F, Walker EF, Huisman THJ. A chromosome with five γ-globin genes. Blood. 1988 Jan 1;72(2):827-829.
Fei, Y. J. ; Lanclos Ke., D. ; Kutlar, F. ; Walker, E. F. ; Huisman, T. H.J. / A chromosome with five γ-globin genes. In: Blood. 1988 ; Vol. 72, No. 2. pp. 827-829.
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