A collaborative study of a new antidepressant, viloxazine, in neurotic and endogenous depressives

W. Guy, T. A. Ban, J. P. McEvoy, W. M. Petrie, W. H. Wilson, J. D. Schaffer

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Abstract

In a multicenter series of trials, viloxazine was compared with imipramine, amitriptyline, doxepin and placebo in 123 neurotic and endogenous depressive inpatients and outpatients. While significant period effects reflecting improvement were obtained on the majority of efficacy variables, no significant differences were obtained among the treatment groups or depressive types. Imipramine and amitriptyline exhibited more anticholinergic adverse reactions; while, viloxazine exhibited greater CNS effects. Dizziness and nausea were much more frequent in neurotic depressives which may be related to their psychopathology.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalUnknown Journal
Volume17
Issue number1
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

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ASJC Scopus subject areas

  • Medicine(all)

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