A comparison of nitrogen mustard, vincristine, procarbazine, and prednisone (mopp) vs. nitrogen mustard in advanced hodgkin's disease

Charles M. Huguley, John R. Durant, Russell R Moores, Yick‐Kwong ‐K Chan, Ronald F. Dorfman, Lorraine Johnson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A randomized study of patients with advanced Hodgkin's disease was designed to determine whether the improved therapeutic effectiveness of combination chemotherapy was due to the use of a combination of drugs or might be achieved with a single agent if given as intensively and for as long a period. A combination of nitrogen mustard, vincristine, procarbazine, and prednisone (MOPP) was compared with nitrogen mustard (HN2) alone. Treatment with both regimens was given to tolerance on cyclic basis and was continued for six cycles of treatment. Sixty‐one evaluable patients were treated with MOPP and 47 with HN2. The complete remission rate of 47.5% with MOPP was significantly better than the 12.8% with HN2 (p < .05). Complete remission lasted a median of 15 months after MOPP and 12 months after HN2. The survival of patients initially treated with MOPP was significantly better than that of those initially treated with HN2.

Original languageEnglish (US)
Pages (from-to)1227-1240
Number of pages14
JournalCancer
Volume36
Issue number4
DOIs
StatePublished - Jan 1 1975

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Procarbazine
Mechlorethamine
Vincristine
Prednisone
Hodgkin Disease
Drug Combinations
Combination Drug Therapy
Therapeutics
Survival

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

A comparison of nitrogen mustard, vincristine, procarbazine, and prednisone (mopp) vs. nitrogen mustard in advanced hodgkin's disease. / Huguley, Charles M.; Durant, John R.; Moores, Russell R; Chan, Yick‐Kwong ‐K; Dorfman, Ronald F.; Johnson, Lorraine.

In: Cancer, Vol. 36, No. 4, 01.01.1975, p. 1227-1240.

Research output: Contribution to journalArticle

Huguley, Charles M. ; Durant, John R. ; Moores, Russell R ; Chan, Yick‐Kwong ‐K ; Dorfman, Ronald F. ; Johnson, Lorraine. / A comparison of nitrogen mustard, vincristine, procarbazine, and prednisone (mopp) vs. nitrogen mustard in advanced hodgkin's disease. In: Cancer. 1975 ; Vol. 36, No. 4. pp. 1227-1240.
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