A computer-assisted cognitive test battery for aged monkeys

J. J. Buccafusco, A. V. Terry, P. B. Murdoch

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

A computer-assisted version of the delayed matching-to-sample (DMTS) task has been of enormous utility in our non-human primate model for assessment of memory-enhancing agents. To avoid ceiling effects as might be encountered by using fixed delay intervals in monkeys exhibiting varying performance efficiencies, delay intervals are adjusted to provide similar baseline levels of delay-dependent performance. Macaques well trained in the task exhibited a marked age-dependent sensitivity to the effects of the amnestic drug scopolamine. Aged animals also were more affected than their younger counterparts by the presentation of a distractor shortly after receiving the stimulus component of the DMTS task. One limitation of the DMTS task is that under baseline conditions certain aged subjects may perform the task as well or better than some younger animals. To help avoid this situation, we developed a titrating version of the DMTS which was administered similarly to the standard DMTS task. Animals begin the first trial with a 0 s delay interval. Delay intervals after a correct response are incremented by 1 s. Delay intervals after an incorrect match are decreased by 1 s. Rhesus and pigtail macaques who ranged in age from 5-27 years and who were maintained on the standard DMTS for at least one year performed 3-4 consecutive 96 trial sessions. The maximum delay intervals attained by the study group, exhibited a significant correlation with age (p < 0.02). Decrements in task accuracy, and in te number of trials completed/session showed a trend with age (p < 0.08). If the titrating version of the DMTS is sensitive to mnemonic drugs, the task may prove useful for drug comparisons with aging.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalJournal of Molecular Neuroscience
Volume19
Issue number1-2
DOIs
StatePublished - Jan 1 2002

Fingerprint

Haplorhini
Macaca nemestrina
Pharmaceutical Preparations
Scopolamine Hydrobromide
Macaca
Macaca mulatta
Primates
Efficiency

Keywords

  • Aging
  • Attention
  • Delayed response task
  • Non-human primate
  • Operant behavior
  • Scopolamine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

A computer-assisted cognitive test battery for aged monkeys. / Buccafusco, J. J.; Terry, A. V.; Murdoch, P. B.

In: Journal of Molecular Neuroscience, Vol. 19, No. 1-2, 01.01.2002, p. 179-185.

Research output: Contribution to journalArticle

Buccafusco, J. J. ; Terry, A. V. ; Murdoch, P. B. / A computer-assisted cognitive test battery for aged monkeys. In: Journal of Molecular Neuroscience. 2002 ; Vol. 19, No. 1-2. pp. 179-185.
@article{d51a6be06a954c4e8c25822a262ee16d,
title = "A computer-assisted cognitive test battery for aged monkeys",
abstract = "A computer-assisted version of the delayed matching-to-sample (DMTS) task has been of enormous utility in our non-human primate model for assessment of memory-enhancing agents. To avoid ceiling effects as might be encountered by using fixed delay intervals in monkeys exhibiting varying performance efficiencies, delay intervals are adjusted to provide similar baseline levels of delay-dependent performance. Macaques well trained in the task exhibited a marked age-dependent sensitivity to the effects of the amnestic drug scopolamine. Aged animals also were more affected than their younger counterparts by the presentation of a distractor shortly after receiving the stimulus component of the DMTS task. One limitation of the DMTS task is that under baseline conditions certain aged subjects may perform the task as well or better than some younger animals. To help avoid this situation, we developed a titrating version of the DMTS which was administered similarly to the standard DMTS task. Animals begin the first trial with a 0 s delay interval. Delay intervals after a correct response are incremented by 1 s. Delay intervals after an incorrect match are decreased by 1 s. Rhesus and pigtail macaques who ranged in age from 5-27 years and who were maintained on the standard DMTS for at least one year performed 3-4 consecutive 96 trial sessions. The maximum delay intervals attained by the study group, exhibited a significant correlation with age (p < 0.02). Decrements in task accuracy, and in te number of trials completed/session showed a trend with age (p < 0.08). If the titrating version of the DMTS is sensitive to mnemonic drugs, the task may prove useful for drug comparisons with aging.",
keywords = "Aging, Attention, Delayed response task, Non-human primate, Operant behavior, Scopolamine",
author = "Buccafusco, {J. J.} and Terry, {A. V.} and Murdoch, {P. B.}",
year = "2002",
month = "1",
day = "1",
doi = "10.1007/s12031-002-0030-6",
language = "English (US)",
volume = "19",
pages = "179--185",
journal = "Journal of Molecular Neuroscience",
issn = "0895-8696",
publisher = "Humana Press",
number = "1-2",

}

TY - JOUR

T1 - A computer-assisted cognitive test battery for aged monkeys

AU - Buccafusco, J. J.

AU - Terry, A. V.

AU - Murdoch, P. B.

PY - 2002/1/1

Y1 - 2002/1/1

N2 - A computer-assisted version of the delayed matching-to-sample (DMTS) task has been of enormous utility in our non-human primate model for assessment of memory-enhancing agents. To avoid ceiling effects as might be encountered by using fixed delay intervals in monkeys exhibiting varying performance efficiencies, delay intervals are adjusted to provide similar baseline levels of delay-dependent performance. Macaques well trained in the task exhibited a marked age-dependent sensitivity to the effects of the amnestic drug scopolamine. Aged animals also were more affected than their younger counterparts by the presentation of a distractor shortly after receiving the stimulus component of the DMTS task. One limitation of the DMTS task is that under baseline conditions certain aged subjects may perform the task as well or better than some younger animals. To help avoid this situation, we developed a titrating version of the DMTS which was administered similarly to the standard DMTS task. Animals begin the first trial with a 0 s delay interval. Delay intervals after a correct response are incremented by 1 s. Delay intervals after an incorrect match are decreased by 1 s. Rhesus and pigtail macaques who ranged in age from 5-27 years and who were maintained on the standard DMTS for at least one year performed 3-4 consecutive 96 trial sessions. The maximum delay intervals attained by the study group, exhibited a significant correlation with age (p < 0.02). Decrements in task accuracy, and in te number of trials completed/session showed a trend with age (p < 0.08). If the titrating version of the DMTS is sensitive to mnemonic drugs, the task may prove useful for drug comparisons with aging.

AB - A computer-assisted version of the delayed matching-to-sample (DMTS) task has been of enormous utility in our non-human primate model for assessment of memory-enhancing agents. To avoid ceiling effects as might be encountered by using fixed delay intervals in monkeys exhibiting varying performance efficiencies, delay intervals are adjusted to provide similar baseline levels of delay-dependent performance. Macaques well trained in the task exhibited a marked age-dependent sensitivity to the effects of the amnestic drug scopolamine. Aged animals also were more affected than their younger counterparts by the presentation of a distractor shortly after receiving the stimulus component of the DMTS task. One limitation of the DMTS task is that under baseline conditions certain aged subjects may perform the task as well or better than some younger animals. To help avoid this situation, we developed a titrating version of the DMTS which was administered similarly to the standard DMTS task. Animals begin the first trial with a 0 s delay interval. Delay intervals after a correct response are incremented by 1 s. Delay intervals after an incorrect match are decreased by 1 s. Rhesus and pigtail macaques who ranged in age from 5-27 years and who were maintained on the standard DMTS for at least one year performed 3-4 consecutive 96 trial sessions. The maximum delay intervals attained by the study group, exhibited a significant correlation with age (p < 0.02). Decrements in task accuracy, and in te number of trials completed/session showed a trend with age (p < 0.08). If the titrating version of the DMTS is sensitive to mnemonic drugs, the task may prove useful for drug comparisons with aging.

KW - Aging

KW - Attention

KW - Delayed response task

KW - Non-human primate

KW - Operant behavior

KW - Scopolamine

UR - http://www.scopus.com/inward/record.url?scp=0036672738&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036672738&partnerID=8YFLogxK

U2 - 10.1007/s12031-002-0030-6

DO - 10.1007/s12031-002-0030-6

M3 - Article

C2 - 12212778

AN - SCOPUS:0036672738

VL - 19

SP - 179

EP - 185

JO - Journal of Molecular Neuroscience

JF - Journal of Molecular Neuroscience

SN - 0895-8696

IS - 1-2

ER -