A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

C. G.P. Mathew, K. S. Chin, D. F. Easton, K. Thorpe, C. Carter, Gregory I Liou, S. L. Fong, C. D.B. Bridges, H. Haak, A. C.Nieuwenhuijzen Kruseman, S. Schifter, H. H. Hansen, H. Telenius, M. Telenius-Berg, B. A.J. Ponder

Research output: Contribution to journalArticle

330 Citations (Scopus)

Abstract

Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).

Original languageEnglish (US)
Pages (from-to)527-528
Number of pages2
JournalNature
Volume328
Issue number6130
DOIs
StatePublished - Jan 1 1987

Fingerprint

Multiple Endocrine Neoplasia Type 2a
Chromosomes, Human, Pair 10
Genetic Markers
Genes
Hyperparathyroidism
DNA Probes
Pheochromocytoma
Chromosomes
Neoplasms

ASJC Scopus subject areas

  • General

Cite this

Mathew, C. G. P., Chin, K. S., Easton, D. F., Thorpe, K., Carter, C., Liou, G. I., ... Ponder, B. A. J. (1987). A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. Nature, 328(6130), 527-528. https://doi.org/10.1038/328527a0

A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. / Mathew, C. G.P.; Chin, K. S.; Easton, D. F.; Thorpe, K.; Carter, C.; Liou, Gregory I; Fong, S. L.; Bridges, C. D.B.; Haak, H.; Kruseman, A. C.Nieuwenhuijzen; Schifter, S.; Hansen, H. H.; Telenius, H.; Telenius-Berg, M.; Ponder, B. A.J.

In: Nature, Vol. 328, No. 6130, 01.01.1987, p. 527-528.

Research output: Contribution to journalArticle

Mathew, CGP, Chin, KS, Easton, DF, Thorpe, K, Carter, C, Liou, GI, Fong, SL, Bridges, CDB, Haak, H, Kruseman, ACN, Schifter, S, Hansen, HH, Telenius, H, Telenius-Berg, M & Ponder, BAJ 1987, 'A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10', Nature, vol. 328, no. 6130, pp. 527-528. https://doi.org/10.1038/328527a0
Mathew CGP, Chin KS, Easton DF, Thorpe K, Carter C, Liou GI et al. A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. Nature. 1987 Jan 1;328(6130):527-528. https://doi.org/10.1038/328527a0
Mathew, C. G.P. ; Chin, K. S. ; Easton, D. F. ; Thorpe, K. ; Carter, C. ; Liou, Gregory I ; Fong, S. L. ; Bridges, C. D.B. ; Haak, H. ; Kruseman, A. C.Nieuwenhuijzen ; Schifter, S. ; Hansen, H. H. ; Telenius, H. ; Telenius-Berg, M. ; Ponder, B. A.J. / A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10. In: Nature. 1987 ; Vol. 328, No. 6130. pp. 527-528.
@article{2cbecb4158404f6c970a00b2e873414c,
title = "A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10",
abstract = "Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).",
author = "Mathew, {C. G.P.} and Chin, {K. S.} and Easton, {D. F.} and K. Thorpe and C. Carter and Liou, {Gregory I} and Fong, {S. L.} and Bridges, {C. D.B.} and H. Haak and Kruseman, {A. C.Nieuwenhuijzen} and S. Schifter and Hansen, {H. H.} and H. Telenius and M. Telenius-Berg and Ponder, {B. A.J.}",
year = "1987",
month = "1",
day = "1",
doi = "10.1038/328527a0",
language = "English (US)",
volume = "328",
pages = "527--528",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6130",

}

TY - JOUR

T1 - A linked genetic marker for multiple endocrine neoplasia type 2A on chromosome 10

AU - Mathew, C. G.P.

AU - Chin, K. S.

AU - Easton, D. F.

AU - Thorpe, K.

AU - Carter, C.

AU - Liou, Gregory I

AU - Fong, S. L.

AU - Bridges, C. D.B.

AU - Haak, H.

AU - Kruseman, A. C.Nieuwenhuijzen

AU - Schifter, S.

AU - Hansen, H. H.

AU - Telenius, H.

AU - Telenius-Berg, M.

AU - Ponder, B. A.J.

PY - 1987/1/1

Y1 - 1987/1/1

N2 - Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).

AB - Multiple endocrine neoplasia type 2A (MEN2A) is an autosomal dominantly inherited cancer syndrome characterized by medullary carcinoma of the thyroid, phaeochromocytoma and hyperparathyroidism. Almost all gene carriers can be detected by screening tests before the age of 40 (ref. 1), but the nature and location of the predisposing gene are unknown. Simpson et al.2 recently reported preliminary evidence for linkage between the DNA probe p9-12A on chromosome 10 and MEN2A. We now report linkage between the MEN2A locus and the interstitial retinol-binding protein gene, which is located on chromosome 10p11.2-q11.2 (ref. 3).

UR - http://www.scopus.com/inward/record.url?scp=0023229266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023229266&partnerID=8YFLogxK

U2 - 10.1038/328527a0

DO - 10.1038/328527a0

M3 - Article

C2 - 2886917

AN - SCOPUS:0023229266

VL - 328

SP - 527

EP - 528

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6130

ER -