A new approach to blood flow simulation in vascular networks

Houman Tamaddon, Mehrdad Behnia, Masud Behnia, Leonard Kritharides

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

A proper analysis of blood flow is contingent upon accurate modelling of the branching pattern and vascular geometry of the network of interest. It is challenging to reconstruct the entire vascular network of any organ experimentally, in particular the pulmonary vasculature, because of its very high number of vessels, complexity of the branching pattern and poor accessibility in vivo. The objective of our research is to develop an innovative approach for the reconstruction of the full pulmonary vascular tree from available morphometric data. Our method consists of the use of morphometric data on those parts of the pulmonary vascular tree that are too small to reconstruct by medical imaging methods. This method is a three-step technique that reconstructs the entire pulmonary arterial tree down to the capillary bed. Vessels greater than 2 mm are reconstructed from direct volume and surface analysis using contrast-enhanced computed tomography. Vessels smaller than 2 mm are reconstructed from available morphometric and distensibility data and rearranged by applying Murray's laws. Implementation of morphometric data to reconstruct the branching pattern and applying Murray's laws to every vessel bifurcation simultaneously leads to an accurate vascular tree reconstruction. The reconstruction algorithm generates full arterial tree topography down to the first capillary bifurcation. Geometry of each order of the vascular tree is generated separately to minimize the construction and simulation time. The node-to-node connectivity along with the diameter and length of every vessel segment is established and order numbers, according to the diameter-defined Strahler system, are assigned. In conclusion, the present model provides a morphological foundation for future analysis of blood flow in the pulmonary circulation

Original languageEnglish (US)
Pages (from-to)673-685
Number of pages13
JournalComputer Methods in Biomechanics and Biomedical Engineering
Volume19
Issue number6
DOIs
StatePublished - Apr 25 2016

Fingerprint

Flow simulation
Blood Vessels
Blood
Bifurcation (mathematics)
Geometry
Trees (mathematics)
Surface analysis
Medical imaging
Topography
Tomography
Lung
Pulmonary Circulation
Diagnostic Imaging
Research

Keywords

  • morphometric data
  • pulmonary circulation
  • Strahler system
  • vascular reconstruction
  • vascular tree

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Human-Computer Interaction
  • Computer Science Applications

Cite this

A new approach to blood flow simulation in vascular networks. / Tamaddon, Houman; Behnia, Mehrdad; Behnia, Masud; Kritharides, Leonard.

In: Computer Methods in Biomechanics and Biomedical Engineering, Vol. 19, No. 6, 25.04.2016, p. 673-685.

Research output: Contribution to journalArticle

Tamaddon, Houman ; Behnia, Mehrdad ; Behnia, Masud ; Kritharides, Leonard. / A new approach to blood flow simulation in vascular networks. In: Computer Methods in Biomechanics and Biomedical Engineering. 2016 ; Vol. 19, No. 6. pp. 673-685.
@article{ea86cf02c8274f8185893d50527b0229,
title = "A new approach to blood flow simulation in vascular networks",
abstract = "A proper analysis of blood flow is contingent upon accurate modelling of the branching pattern and vascular geometry of the network of interest. It is challenging to reconstruct the entire vascular network of any organ experimentally, in particular the pulmonary vasculature, because of its very high number of vessels, complexity of the branching pattern and poor accessibility in vivo. The objective of our research is to develop an innovative approach for the reconstruction of the full pulmonary vascular tree from available morphometric data. Our method consists of the use of morphometric data on those parts of the pulmonary vascular tree that are too small to reconstruct by medical imaging methods. This method is a three-step technique that reconstructs the entire pulmonary arterial tree down to the capillary bed. Vessels greater than 2 mm are reconstructed from direct volume and surface analysis using contrast-enhanced computed tomography. Vessels smaller than 2 mm are reconstructed from available morphometric and distensibility data and rearranged by applying Murray's laws. Implementation of morphometric data to reconstruct the branching pattern and applying Murray's laws to every vessel bifurcation simultaneously leads to an accurate vascular tree reconstruction. The reconstruction algorithm generates full arterial tree topography down to the first capillary bifurcation. Geometry of each order of the vascular tree is generated separately to minimize the construction and simulation time. The node-to-node connectivity along with the diameter and length of every vessel segment is established and order numbers, according to the diameter-defined Strahler system, are assigned. In conclusion, the present model provides a morphological foundation for future analysis of blood flow in the pulmonary circulation",
keywords = "morphometric data, pulmonary circulation, Strahler system, vascular reconstruction, vascular tree",
author = "Houman Tamaddon and Mehrdad Behnia and Masud Behnia and Leonard Kritharides",
year = "2016",
month = "4",
day = "25",
doi = "10.1080/10255842.2015.1058926",
language = "English (US)",
volume = "19",
pages = "673--685",
journal = "Computer Methods in Biomechanics and Biomedical Engineering",
issn = "1025-5842",
publisher = "Informa Healthcare",
number = "6",

}

TY - JOUR

T1 - A new approach to blood flow simulation in vascular networks

AU - Tamaddon, Houman

AU - Behnia, Mehrdad

AU - Behnia, Masud

AU - Kritharides, Leonard

PY - 2016/4/25

Y1 - 2016/4/25

N2 - A proper analysis of blood flow is contingent upon accurate modelling of the branching pattern and vascular geometry of the network of interest. It is challenging to reconstruct the entire vascular network of any organ experimentally, in particular the pulmonary vasculature, because of its very high number of vessels, complexity of the branching pattern and poor accessibility in vivo. The objective of our research is to develop an innovative approach for the reconstruction of the full pulmonary vascular tree from available morphometric data. Our method consists of the use of morphometric data on those parts of the pulmonary vascular tree that are too small to reconstruct by medical imaging methods. This method is a three-step technique that reconstructs the entire pulmonary arterial tree down to the capillary bed. Vessels greater than 2 mm are reconstructed from direct volume and surface analysis using contrast-enhanced computed tomography. Vessels smaller than 2 mm are reconstructed from available morphometric and distensibility data and rearranged by applying Murray's laws. Implementation of morphometric data to reconstruct the branching pattern and applying Murray's laws to every vessel bifurcation simultaneously leads to an accurate vascular tree reconstruction. The reconstruction algorithm generates full arterial tree topography down to the first capillary bifurcation. Geometry of each order of the vascular tree is generated separately to minimize the construction and simulation time. The node-to-node connectivity along with the diameter and length of every vessel segment is established and order numbers, according to the diameter-defined Strahler system, are assigned. In conclusion, the present model provides a morphological foundation for future analysis of blood flow in the pulmonary circulation

AB - A proper analysis of blood flow is contingent upon accurate modelling of the branching pattern and vascular geometry of the network of interest. It is challenging to reconstruct the entire vascular network of any organ experimentally, in particular the pulmonary vasculature, because of its very high number of vessels, complexity of the branching pattern and poor accessibility in vivo. The objective of our research is to develop an innovative approach for the reconstruction of the full pulmonary vascular tree from available morphometric data. Our method consists of the use of morphometric data on those parts of the pulmonary vascular tree that are too small to reconstruct by medical imaging methods. This method is a three-step technique that reconstructs the entire pulmonary arterial tree down to the capillary bed. Vessels greater than 2 mm are reconstructed from direct volume and surface analysis using contrast-enhanced computed tomography. Vessels smaller than 2 mm are reconstructed from available morphometric and distensibility data and rearranged by applying Murray's laws. Implementation of morphometric data to reconstruct the branching pattern and applying Murray's laws to every vessel bifurcation simultaneously leads to an accurate vascular tree reconstruction. The reconstruction algorithm generates full arterial tree topography down to the first capillary bifurcation. Geometry of each order of the vascular tree is generated separately to minimize the construction and simulation time. The node-to-node connectivity along with the diameter and length of every vessel segment is established and order numbers, according to the diameter-defined Strahler system, are assigned. In conclusion, the present model provides a morphological foundation for future analysis of blood flow in the pulmonary circulation

KW - morphometric data

KW - pulmonary circulation

KW - Strahler system

KW - vascular reconstruction

KW - vascular tree

UR - http://www.scopus.com/inward/record.url?scp=84955750756&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955750756&partnerID=8YFLogxK

U2 - 10.1080/10255842.2015.1058926

DO - 10.1080/10255842.2015.1058926

M3 - Article

C2 - 26195135

VL - 19

SP - 673

EP - 685

JO - Computer Methods in Biomechanics and Biomedical Engineering

JF - Computer Methods in Biomechanics and Biomedical Engineering

SN - 1025-5842

IS - 6

ER -