TY - JOUR
T1 - A new chromosome region possibly derived from double minutes in an in vitro transformed epithelial cell line
AU - Cowell, John Kenneth
PY - 1980/1/1
Y1 - 1980/1/1
N2 - Double minute chromosomes (DMs) are reported for the first time in in vitro transformed mouse epithelial cells. In one cell line, CSG 122/17, DMs persisted through numerous passages. A subpopulation appeared in this line at passage 23, in which the DMs had disappeared but were replaced by a finely banded chromosome region possibly associated with the distal end of chromosome 5. In a second cell line, CSG 120/7, there was no evidence of DMs in the earliest frozen stock available. However, a finely banded region similar to that found in CSG 122/17 was present and was again associated with chromosome 5, in this case with the proximal end. The possible evolution of these new chromosome regions from DMs is discussed.
AB - Double minute chromosomes (DMs) are reported for the first time in in vitro transformed mouse epithelial cells. In one cell line, CSG 122/17, DMs persisted through numerous passages. A subpopulation appeared in this line at passage 23, in which the DMs had disappeared but were replaced by a finely banded chromosome region possibly associated with the distal end of chromosome 5. In a second cell line, CSG 120/7, there was no evidence of DMs in the earliest frozen stock available. However, a finely banded region similar to that found in CSG 122/17 was present and was again associated with chromosome 5, in this case with the proximal end. The possible evolution of these new chromosome regions from DMs is discussed.
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M3 - Article
C2 - 7389416
AN - SCOPUS:0018857384
VL - 27
SP - 2
EP - 7
JO - Cytogenetic and Genome Research
JF - Cytogenetic and Genome Research
SN - 1424-8581
IS - 1
ER -