A nonpolymorphic class I gene in the murine major histocompatibility complex

Andrew L. Mellor, Elisabeth H. Weiss, Michel Kress, Gilbert Jay, Richard A. Flavell

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.

Original languageEnglish (US)
Pages (from-to)139-144
Number of pages6
JournalCell
Volume36
Issue number1
DOIs
StatePublished - Jan 1 1984

Fingerprint

MHC Class I Genes
Major Histocompatibility Complex
Genes
Haplotypes
Liver
Peptides
Gene Library
DNA Sequence Analysis
Gene transfer
Exons
Complementary DNA
Clone Cells
DNA sequences
Cell Membrane
Cell membranes
Polymorphism
Mutation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Mellor, A. L., Weiss, E. H., Kress, M., Jay, G., & Flavell, R. A. (1984). A nonpolymorphic class I gene in the murine major histocompatibility complex. Cell, 36(1), 139-144. https://doi.org/10.1016/0092-8674(84)90082-5

A nonpolymorphic class I gene in the murine major histocompatibility complex. / Mellor, Andrew L.; Weiss, Elisabeth H.; Kress, Michel; Jay, Gilbert; Flavell, Richard A.

In: Cell, Vol. 36, No. 1, 01.01.1984, p. 139-144.

Research output: Contribution to journalArticle

Mellor, AL, Weiss, EH, Kress, M, Jay, G & Flavell, RA 1984, 'A nonpolymorphic class I gene in the murine major histocompatibility complex', Cell, vol. 36, no. 1, pp. 139-144. https://doi.org/10.1016/0092-8674(84)90082-5
Mellor, Andrew L. ; Weiss, Elisabeth H. ; Kress, Michel ; Jay, Gilbert ; Flavell, Richard A. / A nonpolymorphic class I gene in the murine major histocompatibility complex. In: Cell. 1984 ; Vol. 36, No. 1. pp. 139-144.
@article{f710359ec3e640799a12b4034449a88e,
title = "A nonpolymorphic class I gene in the murine major histocompatibility complex",
abstract = "DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.",
author = "Mellor, {Andrew L.} and Weiss, {Elisabeth H.} and Michel Kress and Gilbert Jay and Flavell, {Richard A.}",
year = "1984",
month = "1",
day = "1",
doi = "10.1016/0092-8674(84)90082-5",
language = "English (US)",
volume = "36",
pages = "139--144",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - A nonpolymorphic class I gene in the murine major histocompatibility complex

AU - Mellor, Andrew L.

AU - Weiss, Elisabeth H.

AU - Kress, Michel

AU - Jay, Gilbert

AU - Flavell, Richard A.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.

AB - DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.

UR - http://www.scopus.com/inward/record.url?scp=0021342654&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021342654&partnerID=8YFLogxK

U2 - 10.1016/0092-8674(84)90082-5

DO - 10.1016/0092-8674(84)90082-5

M3 - Article

VL - 36

SP - 139

EP - 144

JO - Cell

JF - Cell

SN - 0092-8674

IS - 1

ER -