A nontoxic cholera enterotoxin (CT) analog is chimeric with regard to both epitypes of CT-B subunits, CT-B-1 and CT-B-2

Mary Boesman-Finkelstein, Johnny W. Peterson, Louise S. Thai, Richard A. Finkelstein

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The gene encoding a nontoxic analog, CT-2* of cholera enterotoxin (CT) with attenuating codon substitutions in the A subunit was introduced into the attenuated Vibrio cholerae classical biotype mutant candidate vaccine strain CVD103, which produces the B subunit (but nut the A subunit) of CT-1. The recombinant strain produces a chimeric nontoxic analog holotoxin protein containing both CT-B-1 and CT-B-2 subunits. This offers potential advantages over CVD103 in the induction of immunity against El Tor biotype and V. cholerae O139 strains which produce CT-B-2. The recombinant protein may also be useful in polysaccharide-protein conjugate vaccines against both O1 and O139 serovars of V. cholerae.

Original languageEnglish (US)
Pages (from-to)346-348
Number of pages3
JournalInfection and Immunity
Volume64
Issue number1
DOIs
StatePublished - Jan 1 1996

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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