A novel combinatorial cancer immunotherapy: Poly-IC and blockade of the PD-1/PD-L1 pathway

Toshihiro Nagato; Esteban Celis

doi:10.4161/onci.28440

A novel combinatorial cancer immunotherapy: Poly-IC and blockade of the PD-1/PD-L1 pathway

Toshihiro Nagato, Esteban Celis

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A non-antigen specific immunotherapy consisting of repeated co-administration of poly-IC and blocking antibodies targeting the programmed cell death-1 (PD-1) pathway dramatically inhibits tumor development in several mouse models of cancer. Tumor-reactive CD8+ T cells mediate the antitumor effects mediated by PD-1 blockade. This therapeutic avenue can be readily translated to cancer patient treatment regimens.

Original language	English (US)
Article number	e28440
Journal	OncoImmunology
Volume	3
Issue number	5
DOIs	https://doi.org/10.4161/onci.28440
State	Published - 2014
Externally published	Yes

Keywords

Cancer immunotherapy
Colon cancer
Lung cancer
Melanoma
PD-1
PD-L1
Poly-IC

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/onci.28440

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abstract = "A non-antigen specific immunotherapy consisting of repeated co-administration of poly-IC and blocking antibodies targeting the programmed cell death-1 (PD-1) pathway dramatically inhibits tumor development in several mouse models of cancer. Tumor-reactive CD8+ T cells mediate the antitumor effects mediated by PD-1 blockade. This therapeutic avenue can be readily translated to cancer patient treatment regimens.",

keywords = "Cancer immunotherapy, Colon cancer, Lung cancer, Melanoma, PD-1, PD-L1, Poly-IC",

author = "Toshihiro Nagato and Esteban Celis",

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journal = "OncoImmunology",

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AU - Celis, Esteban

N1 - Funding Information: This work was supported by NIH grants R01CA136828 and R01CA157303 to E.C.

PY - 2014

Y1 - 2014

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AB - A non-antigen specific immunotherapy consisting of repeated co-administration of poly-IC and blocking antibodies targeting the programmed cell death-1 (PD-1) pathway dramatically inhibits tumor development in several mouse models of cancer. Tumor-reactive CD8+ T cells mediate the antitumor effects mediated by PD-1 blockade. This therapeutic avenue can be readily translated to cancer patient treatment regimens.

KW - Cancer immunotherapy

KW - Colon cancer

KW - Lung cancer

KW - Melanoma

KW - PD-1

KW - PD-L1

KW - Poly-IC

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A novel combinatorial cancer immunotherapy: Poly-IC and blockade of the PD-1/PD-L1 pathway

Abstract

Keywords

ASJC Scopus subject areas

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