A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry

Lian Zhou, Robert D. Voyksner, Dhiren R. Thakker, Chad E. Stephens, Mariappan Anbazhagan, David W. Boykin, Richard R. Tidwell, James E. Hall

Research output: Contribution to conferencePaper

Abstract

The formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry was investigated. The formation of an odd electron ion from an even electron ion with the loss of a radical was observed in the fragmentation patterns of DB289. The homolytic bond clevage was verified to occur using deuterium exchange and was observed consistently with this class of compounds. The results showed that the proposed homolytic bond cleavage as the lowest-energy reaction pathway for the molecular ion of DB289.

Original languageEnglish (US)
Pages479-480
Number of pages2
StatePublished - Dec 1 2002
Externally publishedYes
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Other

OtherProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

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Prodrugs
Metabolites
Mass spectrometry
Ions
Electrons
Deuterium

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Zhou, L., Voyksner, R. D., Thakker, D. R., Stephens, C. E., Anbazhagan, M., Boykin, D. W., ... Hall, J. E. (2002). A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry. 479-480. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry. / Zhou, Lian; Voyksner, Robert D.; Thakker, Dhiren R.; Stephens, Chad E.; Anbazhagan, Mariappan; Boykin, David W.; Tidwell, Richard R.; Hall, James E.

2002. 479-480 Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Research output: Contribution to conferencePaper

Zhou, L, Voyksner, RD, Thakker, DR, Stephens, CE, Anbazhagan, M, Boykin, DW, Tidwell, RR & Hall, JE 2002, 'A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry' Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02 - 6/6/02, pp. 479-480.
Zhou L, Voyksner RD, Thakker DR, Stephens CE, Anbazhagan M, Boykin DW et al. A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry. 2002. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.
Zhou, Lian ; Voyksner, Robert D. ; Thakker, Dhiren R. ; Stephens, Chad E. ; Anbazhagan, Mariappan ; Boykin, David W. ; Tidwell, Richard R. ; Hall, James E. / A novel fragmentation pathway involving formation of radical product ions from an antimicrobial prodrug DB289 and selected metabolites using ion trap mass spectrometry. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.2 p.
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