A novel treatment target for Parkinson's disease

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

We hypothesize that GPR109A message and expression are up-regulated in individuals with Parkinson's disease (PD). GPR109A is a high-affinity niacin receptor. Niacin is a precursor for NAD-NADH which is needed for dopamine production. Thus, niacin supplementation may serve three purposes: reduce inflammation through GPR109A-related mechanisms, increase dopamine synthesis in the striatum through NADPH supply and increase NAD/NADH ratio to boost mitochondrial functions. GPR109A and its agonists are known to exert anti-inflammatory actions in the skin, gut and retina. However these roles are neither anticipated nor established in the CNS. For the first time here we propose the roles of GPR109A and its agonists including niacin in CNS pathology. Moreover we predict that the neuroprotective roles of either niacin or butyrates in CNS occur via GPR109A.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalJournal of the Neurological Sciences
Volume347
Issue number1-2
DOIs
StatePublished - Dec 15 2014

Keywords

  • GPR109A
  • HCAR2
  • HM74a
  • Inflammation
  • Niacin
  • Niacinamide

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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