A proprietary topical preparation containing EGCG-stearate and glycerin with inhibitory effects on herpes simplex virus: Case study

Man Zhao, Jinyan Jiang, Rongrong Zheng, Henna Pearl, Douglas Dickinson, Baiping Fu, Stephen Hsu

Research output: Contribution to journalArticle

8 Scopus citations


The effects of a proprietary topical formulation containing EGCG-stearate in 100% glycerin USP were studied in two volunteer patients with recurrent herpes simplex (HSV) type 1. Application during early onset (prodromal stage) in a patient with herpes labialis prevented lesion progression. In a second patient with herpetic stomatitis, application of the formula during a later stage (inflammation stage) led to a remarkably shortened duration of symptoms. In contrast, a third patient provided 100% glycerin USP only as placebo failed to demonstrate any therapeutic or preventive effect against lesion occurrence or duration of lesion and healing time. These results suggest that this proprietary topical preparation could be used effectively to prevent and treat HSV-induced symptoms, and warrants further clinical investigation.

Original languageEnglish (US)
Pages (from-to)364-368
Number of pages5
JournalInflammation and Allergy - Drug Targets
Issue number5
StatePublished - Oct 26 2012



  • Cold sore
  • Green tea polyphenol
  • Herpes labialis
  • Herpes simplex virus
  • Herpes stomatitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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