Abstract
The potential role of cancer stem-like cells (CSCs) in chemoresistance of human oral squamous cell carcinoma (OSCC) was examined. A small subpopulation (1-2%) of CD133+ CSCs was identified in OSCC cell lines and tissues. These CD133+ CSCs possess higher clonogenicity, invasiveness, and increased in vivo tumorigenicity as compared to CD133- counterparts. Meanwhile, CD133+ CSCs were substantially resistant to standard chemotherapy, wherein both in vitro and in vivo treatment with paclitaxel resulted in a marked enrichment for CD133+ CSCs. Our data suggest that CD133+ cells represent a small subpopulation of CSCs that may contribute to chemoresistance in human OSCC.
Original language | English (US) |
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Pages (from-to) | 151-160 |
Number of pages | 10 |
Journal | Cancer Letters |
Volume | 289 |
Issue number | 2 |
DOIs | |
State | Published - Mar 28 2010 |
Externally published | Yes |
Keywords
- CD133 cancer stem-like cell
- Chemoresistance
- Oral squamous cell carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research