Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours

Nicholas R. Lemoine, Christine M. Hughes, John Kenneth Cowell

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM 1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalThe Journal of Pathology
Volume168
Issue number2
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

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Wilms Tumor
Tumor Suppressor Genes
Antibodies
Frozen Sections
Neoplasms
Immunohistochemistry
Monoclonal Antibodies

Keywords

  • immunohistochemistry
  • p53
  • Tumour suppressor gene
  • Wilms' tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours. / Lemoine, Nicholas R.; Hughes, Christine M.; Cowell, John Kenneth.

In: The Journal of Pathology, Vol. 168, No. 2, 01.01.1992, p. 237-242.

Research output: Contribution to journalArticle

Lemoine, Nicholas R. ; Hughes, Christine M. ; Cowell, John Kenneth. / Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours. In: The Journal of Pathology. 1992 ; Vol. 168, No. 2. pp. 237-242.
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