Aberrant expression of the tumour suppressor gene p53 is very frequent in Wilms' tumours

Nicholas R. Lemoine, Christine M. Hughes, John Kenneth Cowell

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

A series of 34 Wilms' tumours have been analysed for abnormal expression of the tumour suppressor gene p53 using frozen section immunohistochemistry. All tumours showed immunoreactivity with at least one of the specific antibodies used (monoclonal antibody PAb240, polyclonal antibodies CM 1 and JG8). Abnormalities of p53 expression are very frequent in this type of childhood tumour.

Original languageEnglish (US)
Pages (from-to)237-242
Number of pages6
JournalThe Journal of Pathology
Volume168
Issue number2
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • immunohistochemistry
  • p53
  • Tumour suppressor gene
  • Wilms' tumour

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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