Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation

Ronenn Roubenoff, Rebecca A. Roubenoff, Jacob Selhub, Marie R. Nadeau, Joseph Gerard Cannon, Lisa M. Freeman, Charles A. Dinarello, Irwin H. Rosenberg

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Objective. To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. Methods. We measured levels of vitamin B6 in 23 adults with well‐controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. Results. Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal‐5′‐phosphate (PLP) were lower in the RA patient group (mean ± SD 46.1 ± 48.1 versus 69.3 ± 58.4 nmoles/liter; P ≤ 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor α (TNFα) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. Conclusion. PLP levels are reduced in patients with RA. This reduction is associated with TNFα production by PBMC.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalArthritis & Rheumatism
Volume38
Issue number1
DOIs
StatePublished - Jan 1 1995

Fingerprint

Cachexia
Vitamin B 6
Rheumatoid Arthritis
Tumor Necrosis Factor-alpha
Inflammation
Blood Cells
Healthy Volunteers
Blood Sedimentation
Vitamin B 12
Folic Acid
Anti-Inflammatory Agents
Multivariate Analysis
Erythrocytes
Weights and Measures
Pain
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Roubenoff, R., Roubenoff, R. A., Selhub, J., Nadeau, M. R., Cannon, J. G., Freeman, L. M., ... Rosenberg, I. H. (1995). Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation. Arthritis & Rheumatism, 38(1), 105-109. https://doi.org/10.1002/art.1780380116

Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation. / Roubenoff, Ronenn; Roubenoff, Rebecca A.; Selhub, Jacob; Nadeau, Marie R.; Cannon, Joseph Gerard; Freeman, Lisa M.; Dinarello, Charles A.; Rosenberg, Irwin H.

In: Arthritis & Rheumatism, Vol. 38, No. 1, 01.01.1995, p. 105-109.

Research output: Contribution to journalArticle

Roubenoff, R, Roubenoff, RA, Selhub, J, Nadeau, MR, Cannon, JG, Freeman, LM, Dinarello, CA & Rosenberg, IH 1995, 'Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation', Arthritis & Rheumatism, vol. 38, no. 1, pp. 105-109. https://doi.org/10.1002/art.1780380116
Roubenoff, Ronenn ; Roubenoff, Rebecca A. ; Selhub, Jacob ; Nadeau, Marie R. ; Cannon, Joseph Gerard ; Freeman, Lisa M. ; Dinarello, Charles A. ; Rosenberg, Irwin H. / Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation. In: Arthritis & Rheumatism. 1995 ; Vol. 38, No. 1. pp. 105-109.
@article{826a2001933d436399f8804b0510e373,
title = "Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation",
abstract = "Objective. To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. Methods. We measured levels of vitamin B6 in 23 adults with well‐controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. Results. Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal‐5′‐phosphate (PLP) were lower in the RA patient group (mean ± SD 46.1 ± 48.1 versus 69.3 ± 58.4 nmoles/liter; P ≤ 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor α (TNFα) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. Conclusion. PLP levels are reduced in patients with RA. This reduction is associated with TNFα production by PBMC.",
author = "Ronenn Roubenoff and Roubenoff, {Rebecca A.} and Jacob Selhub and Nadeau, {Marie R.} and Cannon, {Joseph Gerard} and Freeman, {Lisa M.} and Dinarello, {Charles A.} and Rosenberg, {Irwin H.}",
year = "1995",
month = "1",
day = "1",
doi = "10.1002/art.1780380116",
language = "English (US)",
volume = "38",
pages = "105--109",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "1",

}

TY - JOUR

T1 - Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation

AU - Roubenoff, Ronenn

AU - Roubenoff, Rebecca A.

AU - Selhub, Jacob

AU - Nadeau, Marie R.

AU - Cannon, Joseph Gerard

AU - Freeman, Lisa M.

AU - Dinarello, Charles A.

AU - Rosenberg, Irwin H.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Objective. To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. Methods. We measured levels of vitamin B6 in 23 adults with well‐controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. Results. Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal‐5′‐phosphate (PLP) were lower in the RA patient group (mean ± SD 46.1 ± 48.1 versus 69.3 ± 58.4 nmoles/liter; P ≤ 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor α (TNFα) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. Conclusion. PLP levels are reduced in patients with RA. This reduction is associated with TNFα production by PBMC.

AB - Objective. To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. Methods. We measured levels of vitamin B6 in 23 adults with well‐controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. Results. Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal‐5′‐phosphate (PLP) were lower in the RA patient group (mean ± SD 46.1 ± 48.1 versus 69.3 ± 58.4 nmoles/liter; P ≤ 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor α (TNFα) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. Conclusion. PLP levels are reduced in patients with RA. This reduction is associated with TNFα production by PBMC.

UR - http://www.scopus.com/inward/record.url?scp=0028979359&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028979359&partnerID=8YFLogxK

U2 - 10.1002/art.1780380116

DO - 10.1002/art.1780380116

M3 - Article

C2 - 7818558

AN - SCOPUS:0028979359

VL - 38

SP - 105

EP - 109

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 1

ER -