Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation

Ronenn Roubenoff, Rebecca A. Roubenoff, Jacob Selhub, Marie R. Nadeau, Joseph Gerard Cannon, Lisa M. Freeman, Charles A. Dinarello, Irwin H. Rosenberg

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Objective. To compare vitamin B6 levels in rheumatoid arthritis (RA) patients and healthy control subjects. Methods. We measured levels of vitamin B6 in 23 adults with well‐controlled RA, and in 23 healthy control subjects matched for age, sex, race, and weight. Results. Although plasma folate and vitamin B12 concentrations and erythrocyte B6 activity coefficients were similar in the patients and controls, plasma levels of pyridoxal‐5′‐phosphate (PLP) were lower in the RA patient group (mean ± SD 46.1 ± 48.1 versus 69.3 ± 58.4 nmoles/liter; P ≤ 0.004). In multivariate analyses, PLP was inversely associated with tumor necrosis factor α (TNFα) production by peripheral blood mononuclear cells (PBMC) (P < 0.001), after adjustment for age, pain score, erythrocyte sedimentation rate, and use of nonsteroidal antiinflammatory drugs. Conclusion. PLP levels are reduced in patients with RA. This reduction is associated with TNFα production by PBMC.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalArthritis & Rheumatism
Volume38
Issue number1
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Abnormal vitamin b<sub>6</sub> status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation'. Together they form a unique fingerprint.

  • Cite this

    Roubenoff, R., Roubenoff, R. A., Selhub, J., Nadeau, M. R., Cannon, J. G., Freeman, L. M., Dinarello, C. A., & Rosenberg, I. H. (1995). Abnormal vitamin b6 status in rheumatoid cachexia association with spontaneous tumor necrosis factor α production and markers of inflammation. Arthritis & Rheumatism, 38(1), 105-109. https://doi.org/10.1002/art.1780380116